Renal Disease Burden Following Liver Transplantation

Renal histological lesions and outcome in liver transplant recipients

“…With the success of liver transplantation and improvement in patient survival, kidney dysfunction post‐OLT has become more prevalent and an important cause of morbidity and mortality (1, 2, 21). Kidney dysfunction is considered now to be a major late complication after liver transplantation (22).…”

“…Chronic kidney disease (CKD) is common after orthotopic liver transplantation (OLT) and increases morbidity and mortality post‐transplantation (1, 2). Depending on the definition used, CKD occurs in 18–78% of OLT recipients at five yr post‐transplant (3–6).…”

Liver transplant outcome: a comparison between high and low MELD score recipients

“…Improvements in outcomes following OLT increased long-term patient survival, which allowed identifying some long-term post-transplant complications. Chronic kidney disease (CKD) is one of these complications associated with decreased long-term patient survival, and a common one following liver transplant (16)(17)(18)(19)(20) . CKD is classified according to its severity and the treatment required, and disease progression can lead to a severe renal insufficiency that requires renal transplantation (21) .…”

Everolimus and Enteric-Coated Mycophenolate Sodium Ab Initio after Liver Transplantation: Midterm Results

“…1 Chronic renal dysfunction (CRD) among OLT recipients shows a cumulative incidence of 20% within 3 years and a fourfold increased risk of death. [2][3][4] CRD among OLT recipients has multifactorial origins: female sex, renal disease pretransplantation, primary graft dysfunction, perioperative acute renal damage, recipient age, hepatitis C, hypertension, diabetes mellitus. The prescription of CNIs seems to be the only modifiable risk factor.…”