Renal denervation– new approaches in the search for optimization of hypotensive effect

Башта, Д. И.; Romanov, Alexander; Колесников, В. Н.; Baychorov, Enver; Vilensky, Igor; Trukhachev, Vladimir; Krivoruchko, Alexander; Dannikov, S. P.

doi:10.14300/mnnc.2017.12121

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…Существуют разные версии, объясняющие причину полученных неудовлетворительных результатов. Предполагается, что кратковременность результатов РДН объясняется неспособностью внутрисосудистой радиочастотной аблации вызвать тотальное повреждение симпатических нервных волокон [17]. По мнению экспертов, причинами недостаточной эффективности процедуры также могли быть: 1) особенности функциональной микроанатомии симпатической нервной системы почек [18];…”

Section: оригинальная статьяunclassified

Radiofrequency denervation of the renal arteries in patients with resistant arterial hypertension: 3 years of observation experience

Savelyeva

Юрьевна²,

Zherzhova

et al. 2019

System. Hyper.

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Objective. To evaluate the efficiency of radiofrequency denervation of the renal arteries in patients with resi-stant arterial hypertension during a three-year follow-up. Materials and methods. The study involved 40 patients with resistant arterial hypertension aged 27 to 70 years (mean age 54.91±9.77 years) while receiving three or more antihypertensive drugs (including diuretic) in optimal doses. The conditions for inclusion in the study were considered resistant arterial hypertension with blood pressure (BP)>160/100 mm Hg, intact kidney function - glomerular filtration rate (MDRD)>45 ml/min - and the absence of secondary hypertension. All patients had sympatic radiofrequency denervation of renal arteries; its efficiency later was estimated according to the clinical measurement and ambulatory blood pressure monitoring (ABPM). Results. The level of office BP reliably differed initially and after 3 years: DSBP -34.48±6.44 mm Hg (p=0.001), DDBP - 22.29 mm Hg (p=0.001). According to ABPM results, reliable dynamics of systolic blood pressure was not observed. The data of DBP at night were significantly lower after 36 months; DDBP was -5.37±9.77 mm Hg. Conclusions. A marked decrease in the data of office SBP and DBP was observed, which proves the long-term efficiency of radiofrequency denervation of the renal arteries in patients with resistant hypertension. Accor-ding to ABPM results after 36 months, a significant decrease was registered among the DBP indicators at night and daytime.

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Section: оригинальная статьяunclassified

Radiofrequency denervation of the renal arteries in patients with resistant arterial hypertension: 3 years of observation experience

Savelyeva

Юрьевна²,

Zherzhova

et al. 2019

System. Hyper.

View full text Add to dashboard Cite

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Laparoscopic approach for renal denervation: an experimental study on animals

Bashta,

Vilenskiy,

Krivosheev

et al. 2023

Vestnik aritmologii

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Aim. To study the efficacy and safety of laparoscopic mechanical renal denervation.Methods. Thirty sheep with mean weight 92.3±2.1 kg were divided in 2 groups: control group (group I, n=15) and mechanical laparoscopic renal denervation group (group II, n=15). The follow-up period was 6 months. The following parameters were assessed: blood pressure in response to high-frequency electrical intraluminal stimulation, creatinine, blood urea nitrogen test (BUN), damage to the renal arteries according to the result of angiography, the degree of destruction of nerve fibers according to histological examination.Results. All animals were alive during the entire observation period. The creatinine and BUN were within the normal ranges during the observation period. Angiography of the renal arteries did not reveal iatrogenic stenotic lesions. After 6 months in group 2 there was hypertensive response of blood pressure to high-frequency electrical stimulation (increased systolic blood pressure ∆70.27±5.31 (p>0.005), diastolic blood pressure ∆49.87±6.05 (p>0.005)). After 6 months, the animals were euthonised, further histological examination was completed. Histological examination: in the group II, there was swelling and vacuolization of the nerve fiber without signs of demyelination.Conclusions. Laparoscopic mechanical renal denervation is a safe technique. However, the hypotensive effect is short-term.

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Renal denervation– new approaches in the search for optimization of hypotensive effect

Cited by 2 publications

References 2 publications

Radiofrequency denervation of the renal arteries in patients with resistant arterial hypertension: 3 years of observation experience

Radiofrequency denervation of the renal arteries in patients with resistant arterial hypertension: 3 years of observation experience

Laparoscopic approach for renal denervation: an experimental study on animals

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