Renal Denervation Influences Angiotensin II Types 1 and 2 Receptors

Abstract

The sympathetic and renin-angiotensin systems (RAS) are two critical regulatory systems in the kidney which affect renal hemodynamics and function. These two systems interact with each other so that angiotensin II (Ang II) has the presynaptic effect on the norepinephrine secretion. Another aspect of this interaction is that the sympathetic nervous system affects the function and expression of local RAS receptors, mainly Ang II receptors. Therefore, in many pathological conditions associated with an increased renal sympathetic tone, these receptors’ expression changes and renal denervation can normalize these changes and improve the diseases. It seems that the renal sympathectomy can alter Ang II receptors expression and the distribution of RAS receptors in the kidneys, which influence renal functions.

The role of Mas receptor on renal hemodynamic responses to angiotensin II administration in chronic renal sympathectomized male and female rats

“…Increased oscillatory activity augments vascular resistance by boosting calcium flux in the vascular smooth muscle membrane ( 40 ). In addition to increasing gap junctions ( 41 ), denervation also raises responsiveness to adrenergic agonists and vascular resistance through increasing receptor affinity ( 42 ).…”

“…The cutoff of sympathetic nerves in cardiomyopathy also leads to changes in AT1R and MasR ( 72 ). It appears that renal sympathectomy can affect renal function by affecting the expression of angiotensin receptors and MasR ( 42 ).…”