Renal denervation for the treatment of ventricular arrhythmias: A systematic review and meta‐analysis

Abstract

Introduction: Ventricular arrhythmias (VAs) are a major cause of morbidity and mortality in patients with heart disease. Recent studies evaluated the effect of renal denervation (RDN) on the occurrence of VAs. We conducted a systematic review and metaanalysis to determine the efficacy and safety of this procedure.Methods and Results: A systematic search of the literature was performed to identify studies that evaluated the use of RDN for the management of VAs. Primary outcomes were reduction in the number of VAs and implantable cardioverter-defibrillator (ICD) therapies. Secondary outcomes were changes in blood pressure and renal function. Ten studies (152 patients) were included in the meta-analysis. RDN was associated with a reduction in the number of VAs, antitachycardia pacing, ICD shocks, and overall ICD therapies of 3.53 events/patient/month (95% confidence interval [CI] = −5.48 to −1.57), 2.86 events/patient/month (95% CI = −4.09 to −1.63), 2.04 events/patient/month (95% CI = −2.12 to −1.97), and 2.68 events/patient/month (95% CI = −3.58 to −1.78), respectively. Periprocedural adverse events occurred in 1.23% of patients and no significant changes were seen in blood pressure or renal function. Conclusions:In patients with refractory VAs, RDN was associated with a reduction in the number of VAs and ICD therapies, and was shown to be a safe procedure.

Emergency Management of Electrical Storm: A Practical Overview

“…In addition to that, renal denervation could be promising for control of the sympathetic tone. Only limited data are available [ 105 , 106 ], but they seem to demonstrate that renal denervation could be an effective second-line treatment option in patients with ES and reduced LVEF when conventional catheter ablation and multiple medical treatment attempts fail to control the VTs. Its efficacy has been proved both in ICM and NICM.…”