Renal denervation for improving outcomes of catheter ablation in patients with atrial fibrillation and hypertension: Early experience

EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication

“…Recent preliminary studies have suggested that aggressive treatment of hypertension improves postablation outcomes. 200,464,465 Heart failure and atrial fibrillation ablation Contractile dysfunction has similarly been associated with advanced atrial remodelling and predisposition to atrial fibrillation both in basic and in clinical studies. 113,433 Numerous studies have evaluated the efficacy of catheter ablation of both paroxysmal and persistent atrial fibrillation with significant impairment of systolic function.…”

The impact of renal sympathetic denervation on cardiac electrophysiology and arrhythmias: A systematic review of the literature

“…The patients were further classified to moderate or severe resistant hypertension. At 12 months follow-up a significantly higher proportion of patients in the PVI and RDN group remained AF-free compared to PVI alone [36]. Furthermore, the combined strategy was more effective in patients with severe resistant hypertension patients compared to moderate resistant hypertension patients [36].…”

“…A recent meta-analysis of two randomized studies included patients with paroxysmal or persistent AF which randomized either to PVI alone or to PVI and RDN [36]. The patients were further classified to moderate or severe resistant hypertension.…”

Neuromodulation for cardiac arrhythmia

“…Linz et al [94] reported that RSD reduced BP, atrial ERP shortening and AF inducibility in a model of obstructive sleep apnea. The potential role of RSD as an adjunct to PVI in patients with AF and resistant hypertension was also promising [95] . Adding RSD to PVI provided additional benefits particularly in persistent AF patients with severe hypertension.…”