Renal Data from the Arab World Dialysis in Kuwait: 2013-2019

AlSahow, Ali; Al-Helal, Bassam; Alyousef, Anas; AlQallaf, Ahmad; Marzouq, A.; Nawar, Hani; Fanous, G.; Abdelaty, Mohammed Hassan; Bahbahani, Yousif; AlRajab, Heba; AlTerkait, Aisha; Ali, Hamad

doi:10.4103/1319-2442.292317

Cited by 9 publications

(10 citation statements)

References 8 publications

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“…The current available treatment option for rapidly progressive ADPKD patients reaching ESRD in Kuwait is renal replacement therapy, which is placing a significant burden on ESRD care facilities. In a recent study on the dialysis population in Kuwait, PKD was shown to account for ≈2% of the total dialysis population [ 51 ]. However, unpublished data on renal transplants in Kuwait show that ADPKD cases accounted for 9.73% of total renal transplants performed between 2016 and 2019 ( Supplementary Table 3 ).…”

Section: Discussionmentioning

confidence: 99%

The genetic landscape of autosomal dominant polycystic kidney disease in Kuwait

Ali

Naim

Serum

et al. 2022

Clinical Kidney Journal

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Background Autosomal dominant polycystic kidney disease (ADPKD) is the most common renal monogenic disease and characterized by bilateral accumulation of renal fluid-filled cysts leading to progressive renal volume enlargement and gradual impairment of kidney function which often resulting in ESRD. Kuwait could provide valuable genetic insight about ADPKD including intrafamilial phenotypic variation, given its large household size. This study aims to provide a comprehensive description of the pathogenic variants linked to ADPKD in the Kuwaiti population using multiple genetic analysis modalities and to describe and analyze the ADPKD phenotypic spectrum in term of kidney function, kidney volume and renal survival. Methods 126 ADPKD patients from 11 multiplex families and 25 singletons were recruited in the study. A combination of targeted next generation sequencing (tNGS), long range (LR) -PCR, Sanger sequencing and multiplex-ligation dependent probe amplification (MLPA) were utilized for genetic diagnosis. Clinical evaluation was conducted through Renal Function Test (RFT) and ultrasonographic kidney volume analysis. Results We identified 29 ADPKD pathogenic mutations from 36 families achieving an overall molecular genetic diagnostic rate of 112/126 (88.9%) including 29/36 (80.6%) in families. 28/36 (77.8%) of families had pathogenic mutations in PKD1, of which 17/28 (60.7%) were truncating, and 1/36 (2.8%) had a pathogenic variant in IFT140 gene. 20/29 (69%) of the identified ADPKD mutations were novel and described for the first time including a TSC2-PKD1 contiguous syndrome. Clinical analysis indicated that genetically unresolved ADPKD cases had no apparent association between kidney volume and age. Conclusion We describe for the first time the genetic landscape of ADPKD in Kuwait. The observed genetic heterogeneity underlining ADPKD along with the wide phenotypic spectrum reveals the level of complexity in disease pathophysiology. ADPKD genetic testing could improve care of patients through improving disease prognostication, guided treatment, as well as genetic counseling. However, to fulfill the potential of genetic testing, it is important to overcome the hurdle of genetically unresolved ADPKD cases.

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Section: Discussionmentioning

confidence: 99%

The genetic landscape of autosomal dominant polycystic kidney disease in Kuwait

Ali

Naim

Serum

et al. 2022

Clinical Kidney Journal

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“…Only Mubarak and Jahra hospitals provide pediatric nephrology services, and Mubarak provides dialysis service for 10 patients on HD and 18 on PD. Pediatric patients are transferred to adult care after the age of 12 years (8). Each MoH nephrology unit requests new equipment (HD/ PD machines, ultrasound, monitors, beds, scales, etc.)…”

Section: Public Sectormentioning

confidence: 99%

“…">Ministry of Health (MoH):MoH divides Kuwait into six health regions. 7,8 Each region has a hospital that provides full adult nephrology services (figure 1), including chronic PD and in-center HD, outpatient clinics (with pharmacy and intravenous therapies), vascular access procedures, and inpatient services including acute dialysis (intermittent HD or continuous renal replacement therapy [CRRT]), catheter insertion, plasma exchange, and urgent urological intervention. Inpatient services are free of charge for all in MoH hospitals.…”

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Global Dialysis Perspective: Kuwait

AlSahow

Alyousef

2021

Kidney360

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“…Diabetic nephropathy (DN) is a kidney-related complication that affects approximately 40% of patients with type 1 and type 2 diabetes mellitus (T1D and T2D, respectively), and is one of the most common causes of end-stage renal disease (ESRD) worldwide [ 1 , 2 ]. It is a progressive condition that gradually impairs kidney function.…”

Section: Introductionmentioning

confidence: 99%

Association of significantly elevated plasma levels of NGAL and IGFBP4 in patients with diabetic nephropathy

et al. 2022

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Background Diabetic nephropathy (DN) is a type of progressive kidney disease affecting approximately 40% of patients with diabetes. Current DN diagnostic criteria predominantly rely on albuminuria and serum creatinine (sCr) levels. However, the specificity and reliability of both markers are limited. Hence, reliable biomarkers are required for early diagnosis to effectively manage DN progression. Methods In this study, a cohort of 159 individuals were clinically evaluated and the plasma levels of NGAL, IGFBP-1, IGFBP-3, and IGFBP-4 were determined using Multiplexing Assays. Additionally, the association between the plasma levels of NGAL, IGFBP-1, IGFBP-3, and IGFBP-4 in patients with DN were compared to those in patients with T2D without kidney disease and control participants. Results Circulating level of NGAL were significantly higher in people with DN compared to people with T2D and non-diabetic groups (92.76 ± 7.5, 57.22 ± 8.7, and 52.47 ± 2.9 mg/L, respectively; p < 0.0001). IGFBP-4 showed a similar pattern, where it was highest in people with DN (795.61 ng/ml ±130.7) compared to T2D and non-diabetic people (374.56 ng/ml ±86.8, 273.06 ng/ml ±27.8 respectively, ANOVA p < 0.01). The data from this study shows a significant positive correlation between NGAL and IGFBP-4 in people with DN (ρ = .620, p < 0.005). IGFBP-4 also correlated positively with creatinine level and negatively with eGFR, in people with DN supporting its involvement in DN. Conclusion The data from this study shows a parallel increase in the plasma levels of NGAL and IGFBP-4 in DN. This highlights the potential to use these markers for early diagnosis of DN.

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Renal Data from the Arab World Dialysis in Kuwait: 2013-2019

Cited by 9 publications

References 8 publications

The genetic landscape of autosomal dominant polycystic kidney disease in Kuwait

The genetic landscape of autosomal dominant polycystic kidney disease in Kuwait

Global Dialysis Perspective: Kuwait

Association of significantly elevated plasma levels of NGAL and IGFBP4 in patients with diabetic nephropathy

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