Renal Cystic Diseases

Bisceglia, Michele; Galliani, Carlos; Senger, Christof; Stallone, C.; Sessa, A.

doi:10.1097/01.pap.0000201831.77472.d3

Cited by 220 publications

(221 citation statements)

References 202 publications

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“…[8][9][10] Simple renal cyst is the most common structural abnormality observed in human kidneys, with prevalence ranging from 5-41%. 11,12 Similarly to what is seen with AAA, the prevalence of SRCs increases with age and in male population. 13 The majority of SRCs are asymptomatic, not harmful and incidentally found by renal imaging, including computed tomography (CT) and ultrasonography.…”

Section: Introductionmentioning

confidence: 90%

“…Most SRCs are clinically irrelevant and seldom require treatment. 11,13 Some authors hypothesized that AAA and SRC might share common pathophysiological mechanisms, including possible manifestation of connective tissue weakness. 14 Furthermore, the association between SCRs and AAA might be of clinical importance for the early recognition of patients at risk for the aortic aneurysmal disease.…”

Section: Introductionmentioning

confidence: 99%

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Association between renal cysts and abdominal aortic aneurysm: A case-control study

Veiga

Silva

Bellucci

et al. 2017

Rev. Assoc. Med. Bras.

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Objective: To investigate the positive association between the presence of simple renal cysts (SRCs) and abdominal aortic aneurysm (AAA). Method: In a retrospective case-control study including subjects aged > 50 years, we evaluated the incidence of SRCs on computed tomography (CT) scan. We compared 91 consecutive patients with AAA referred from the Division of Vascular Surgery and 396 patients without AAA, randomly selected after being matched by age and gender from 3,186 consecutive patients who underwent abdominal CT. SRC was defined as a round or oval low-attenuation lesion with a thin wall and size > 4 mm on CT without obvious evidence of radiographic enhancement or septations. Patients were considered as having AAA if the size of aorta was greater than 3.0 cm. Results: Patients with AAA and without AAA were similar in terms of age (67.9± 8.41 vs. 68.5±9.13 years) (p=0.889) and gender (71.4 vs. 71.2% of male subjects, respectively) (p=0.999). There was no difference in the prevalence of SRC between case and controls. Among individuals with AAA, 38 (41.8%; [95CI 32.5-52.6]) had renal cysts compared to 148 (37.4%;) in the control group (p=0.473), with a prevalence ratio (PR) of 1.16 (95CI 0.80-1.68). Conclusion: We found no significant differences in the prevalence of SRCs among patients with AAA and controls. Our findings suggest that the presence of SRCs is not a risk factor or a marker for AAA.

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Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Association between renal cysts and abdominal aortic aneurysm: A case-control study

Veiga

Silva

Bellucci

et al. 2017

Rev. Assoc. Med. Bras.

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“…36 Simple cysts likely originate from the distal convoluted or collecting duct and are thought to arise from renal tubular diverticula, or from tubular cell hyperplasia secondary to nephron loss. [37][38][39] Previous studies in healthy subjects described associations between hypertension and benign renal cysts. [40][41][42] In a cross-sectional analysis of hospitalized patients without overt renal disease undergoing an abdominal computed tomography scan, the presence of cysts was associated with a reduced renal function estimated by creatinine clearance.…”

Section: Discussionmentioning

confidence: 99%

Copeptin Is Associated with Kidney Length, Renal Function, and Prevalence of Simple Cysts in a Population-Based Study

Ponte

Pruijm

Ackermann

et al. 2015

Journal of the American Society of Nephrology

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Arginine vasopressin (AVP) has a key role in osmoregulation by facilitating water transport in the collecting duct. Recent evidence suggests that AVP may have additional effects on renal function and favor cyst growth in polycystic kidney disease. Whether AVP also affects kidney structure in the general population is unknown. We analyzed the association of copeptin, an established surrogate for AVP, with parameters of renal function and morphology in a multicentric population-based cohort. Participants from families of European ancestry were randomly selected in three Swiss cities. We used linear multilevel regression analysis to explore the association of copeptin with renal function parameters as well as kidney length and the presence of simple renal cysts assessed by ultrasound examination. Copeptin levels were log-transformed. The 529 women and 481 men had median copeptin levels of 3.0 and 5.2 pmol/L, respectively (P,0.001). In multivariable analyses, the copeptin level was associated inversely with eGFR (b=22.1; 95% confidence interval [95% CI], 23.3 to 20.8; P=0.002) and kidney length (b=21.2; 95% CI, 21.9 to 20.4; P=0.003) but positively with 24-hour urinary albumin excretion (b=0.11; 95% CI, 0.01 to 0.20; P=0.03) and urine osmolality (b=0.08; 95% CI, 0.05 to 0.10; P,0.001). A positive association was found between the copeptin level and the presence of renal cysts (odds ratio, 1.6; 95% CI, 1.1 to 2.4; P=0.02). These results suggest that AVP has a pleiotropic role in renal function and may favor the development of simple renal cysts. The antidiuretic hormone arginine vasopressin (AVP) plays an essential role in osmoregulation by facilitating water transport in the collecting duct. 1 This effect is mediated by the stimulation of the G protein-coupled vasopressin V2 receptor (V2R), increasing cAMP levels and leading to a transient increase in osmotic water transport across the principal cells. 2 Furthermore, it was recently demonstrated that V2Rs are also expressed in the thick ascending limb of the human kidney. 3,4 In addition to the V2R, AVP acts on the V1a receptor (Ca 2+ as second messenger), which is distributed in the endothelial cells lining systemic and renal blood vessels and capillaries (including vasa recta), as well as the glomerulus, the macula densa, the medullary interstitial cells, and the cortical collecting duct. [5][6][7] Of note, V1a receptors seem to

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“…Occasionally, they become symptomatic and might present with abdominal discomfort, flank pain, a palpable mass, or hematuria [8] . These clinical symptoms can be a result of complications (hemorrhage, infection, and rupture), or a complaint because of an enlarging cyst, and clinical symptoms might raise the possibility of an associated malignancy [12][13][14] . However, the relationship between renal cyst and renal malignancy has not been confirmed.…”

Section: Discussionmentioning

confidence: 99%

The Growth of Renal Cysts According to the Exophytic Index of the RENAL Nephrometry Scoring System

Park

Kang

2016

Journal of Nephrology Research

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higher than mild and moderate exophytic renal cyst. INTRODUCTIONRenal cysts are acquired lesions that most commonly affect the elderly population [1] . Autopsy studies have reported a 50% incidence of renal cysts after the age of 50 years [2] . The prevalence of renal cysts is approximately 10%, ranging from 4% in the third decade to 19% in the sixth decade [3] . There is an increase in the size and number of cysts over time in cyst-bearing individuals. Previous longterm follow-up data have shown that, simple renal cysts continue to increase in size with age > 10 years, and sometimes increase rapidly, particularly in younger patients [4] . However, this study also showed decreased growth rate of cysts with increased age. Renal cysts originate from weakened of the tubular basement membrane of the distal convoluted or collecting duct cells [2] . As results, a diverticulum is formed, which can subsequently develop into a simple renal cyst [5,6] . The reported risk factors for renal cysts include old age, male gender, renal dysfunction, and hypertension [7] . However, given the retrospective nature of these studies, the associations could be coincidental. The only persistent confounder among all reported associations was increasing age [4,7,8] . Therefore, we analyzed the discrepancy of an increasing rate of simple renal cysts according to initial size, location, and exophytic index stratified using the RENAL nephrometry scoring system in this study. MATERIALS AND METHODS Study populationThis study was conducted after receiving approval from our ABSTRACT AIM: To investigate the growth patterns of renal cysts according to location, exophytic degree and Bosniak classification. METHODS: From December 2000 to September 2012, a total of 252 patients (340 renal cysts) were included in this study. All patients had undergone computed tomography (CT) scans of the kidney level at least twice, and six months apart for any reason. Renal cyst data were assessed according to cyst side (right or left), location (upper, mid or lower), characteristics (Bosniak classification), and exophytic degree (1,2, and 3) which were stratified using the RENAL nephrometry score. The growth rate of renal cyst was analyzed according to each parameter using linear correlation analysis. RESULTS:The mean size of renal cyst increased from 3.81 cm to 3.85 cm during a mean follow-up of 20.1 months, not significantly (p = 0.121). Among 340 renal cyst units, 180 renal cysts had an exophytic degree index of 1 (52.9%), 90 had an index 2 (26.5%), and 70 had an index of 3 (20.6%). After a mean of 20.1 months of follow-up, only exophytic degree 3 renal cysts increased in size significantly from 4.54 to 5.76 cm (p = 0.018). The annual growth rate in exophytic degree 3 renal cysts was 2.4 mm (r 2 = 0.263), which was higher than that for renal cysts at other site locations. CONCLUSION: The growth rate of renal cysts varied according to exophytic location. The growth rate of exophytic renal cysts was

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Renal Cystic Diseases

Cited by 220 publications

References 202 publications

Association between renal cysts and abdominal aortic aneurysm: A case-control study

Association between renal cysts and abdominal aortic aneurysm: A case-control study

Copeptin Is Associated with Kidney Length, Renal Function, and Prevalence of Simple Cysts in a Population-Based Study

The Growth of Renal Cysts According to the Exophytic Index of the RENAL Nephrometry Scoring System

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