Renal Cortical Scarring:<sup>68</sup>Ga-PSMA-11 PET Versus<sup>99m</sup>Tc-DMSA Scanning in a Case of Pyelonephritis

Sarıkaya, İsmet; Alqallaf, Ahmed; Sarıkaya, Ali; Baqer, Ali; Kazem, Nafisa

doi:10.2967/jnmt.121.262415

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…Despite its name, PSMA is also expressed in non‐prostatic tissues, such as the proximal tubules of the kidneys (Kinoshita et al, 2006 ; Silver et al, 1997 ). Two PSMA radiopharmaceuticals for PET use, 68 Ga‐PSMA‐11 and 18 F‐PSMA‐1007, display significant renal uptake and are being explored as alternatives to 99m Tc‐DMSA scintigraphy for renal cortical imaging (Ahmadi Bidakhvidi et al, 2021 ; Sarikaya et al, 2018 , 2021 ; Valind et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

[¹⁸F]PSMA‐1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate

Valind

Jögi

Minarik

et al. 2022

Clin Physio Funct Imaging

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Background Scintigraphy with technetium‐99m‐labelled dimercaptosuccinic acid ([99mTc]Tc‐DMSA) is widely used for renal cortical imaging. Uptake of [99mTc]Tc‐DMSA has been shown to correlate with glomerular filtration rate (GFR). Prostate‐specific membrane antigen (PSMA) radiopharmaceuticals used for positron emission tomography (PET) show high renal uptake and are being investigated for renal imaging. [68Ga]Ga‐PSMA‐11 PET parameters have been shown to correlate with estimated GFR (eGFR). The aim of this study was to investigate the relationship between renal [18F]PSMA‐1007 uptake and eGFR. Methods Hundred and eighty‐five patients underwent PET imaging at 1 and 2 h after injection of 4.0 ± 0.2 MBq [18F]PSMA‐1007. Serum creatinine levels were measured and GFR estimated using the Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) and Modification of Diet in Renal Disease (MDRD) equations. Fifteen patients were excluded due to missing or incorrect data. Thus, data from 170 patients were analyzed. Kidneys were segmented in the PET images using a convolutional neural network with manual correction. For each kidney, mean standardized uptake value (SUVmean) and segmentation volume in millilitres were measured. Linear regression analyses were performed with eGFR as the outcome variable. Results Variation in the eGFR values was explained to a significant degree by SUVmean and renal segmentation volume in both the 1 and 2 h images. This correlation was stronger for CKD‐EPI eGFR (1 h R2 = 0.64; 2 h R2 = 0.64) than for MDRD eGFR (1 h R2 = 0.47; 2 h R2 = 0.45). Conclusion Renal [18F]PSMA‐1007 uptake parameters correlate with eGFR and are indicative of renal cortical function.

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Section: Introductionmentioning

confidence: 99%

[¹⁸F]PSMA‐1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate

Valind

Jögi

Minarik

et al. 2022

Clin Physio Funct Imaging

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“…The use of PSMA PET has been suggested for functional imaging of the renal cortex [ 4 , 5 ]. [ 68 Ga]Ga-PSMA-11 PET has been compared to technetium-99m labeled dimercaptosuccinic acid (DMSA) scan in two adult patients with pyelonephritis [ 6 , 7 ]. A recent study has shown correlation between renal uptake of [ 68 Ga]Ga-PSMA-11 and renal function as measured with glomerular filtration rate (GFR) [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Dose-reduced [18F]PSMA-1007 PET is feasible for functional imaging of the renal cortex

et al. 2021

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Background In Prostate-specific membrane antigen (PSMA) positron emission tomography with computed tomography (PET-CT), there is significant renal uptake. The standard in renal cortical functional imaging is scintigraphy with technetium-99m labeled dimercaptosuccinic acid (DMSA). Using [68Ga]Ga-PSMA-11 PET for renal imaging has been suggested, but using [18F]PSMA-1007 has not been explored. The aims of this study were to establish the optimal time point for renal imaging after [18F]PSMA-1007 injection, to investigate the reproducibility of split renal uptake measurements, and to determine the margin for reduction in administered activity. Methods Twelve adult male patients with prostate cancer underwent [18F]PSMA-1007 PET-CT at 8 time points up to 5.5 h post-injection (p.i.). List-mode data were binned to durations of 10 to 120 s per bed position (bp). Left renal percentage of total renal uptake (LRU%) was measured, and the difference between highest and lowest measurement per patient (“delta max”) was calculated. Images acquired at 1 h, 2 h, and 5.5 h p.i. with durations of 10 to 120 s/bp were rated regarding image quality. Results Imaging at 2 h p.i. with 60 s/bp yielded acceptable quality in all cases. Increasing acquisition time to 15 min for a single bp would allow reducing administered activity to 0.27 MBq/kg, resulting in an effective dose of 0.4 mSv for a 1-year old child weighing 10 kg. The median delta max of LRU% measurements was 2.7% (range 1.8–7.3%). Conclusions Renal [18F]PSMA-1007 PET-CT is feasible, with imaging 2 h p.i., acceptable split renal uptake variability, and effective dose and acquisition time comparable to those of [99mTc]Tc-DMSA scintigraphy.

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“…In a prospective study, we compared 68 Ga-PSMA-11 PET to 99m Tc-dimercaptosuccinic acid (DMSA) scan in adult patients with pyelonephritis. Our study was interrupted by Covid-19 pandemic but we were able to obtain renal PSMA PET and DMSA images in 2 adult patients with pyelonephritis [ 5 , 6 ]. In our cases, renal PSMA PET provided superior image resolution over DMSA scan and demonstrated the scar formation from pyelonephritis.…”

mentioning

confidence: 99%

“…Non-attenuation corrected PSMA PET also provided high resolution images of the kidneys. Estimated effective doses of 111 MBq (3 mCi) of 99m Tc-DMSA and 37 MBq (1 mCi) of 68 Ga-PSMA-11 seems comparable [ 5 , 6 ]. We also assessed the correlation between 68 Ga-PSMA-11 renal PET parameters and renal function tests in patients with prostate cancers [ 7 ].…”

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confidence: 99%

Letter to the Editor: 68Ga-PSMA-11 for renal cortical PET imaging

Sarıkaya

2022

Clin Transl Imaging

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Renal Cortical Scarring:⁶⁸Ga-PSMA-11 PET Versus^99mTc-DMSA Scanning in a Case of Pyelonephritis

Cited by 5 publications

References 21 publications

[¹⁸F]PSMA‐1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate

[¹⁸F]PSMA‐1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate

Dose-reduced [18F]PSMA-1007 PET is feasible for functional imaging of the renal cortex

Letter to the Editor: 68Ga-PSMA-11 for renal cortical PET imaging

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Renal Cortical Scarring:68Ga-PSMA-11 PET Versus99mTc-DMSA Scanning in a Case of Pyelonephritis

Cited by 5 publications

References 21 publications

[18F]PSMA‐1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate

[18F]PSMA‐1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate

Dose-reduced [18F]PSMA-1007 PET is feasible for functional imaging of the renal cortex

Letter to the Editor: 68Ga-PSMA-11 for renal cortical PET imaging

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Renal Cortical Scarring:⁶⁸Ga-PSMA-11 PET Versus^99mTc-DMSA Scanning in a Case of Pyelonephritis

[¹⁸F]PSMA‐1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate

[¹⁸F]PSMA‐1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate