Renal contribution to thermolability in rats: role of renal nerves

Lutaif, Nelson Afonso; Rocha, Eduardo Melani; Veloso, Lício A; Bento, Leda Márcia Araújo; Gontijo, José Antônio Rocha

doi:10.1093/ndt/gfn368

Cited by 7 publications

(10 citation statements)

References 35 publications

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“…Nevertheless, in the present study, BT had a significant predictive value among cats with AKI. It is well known that the kidney plays a role in thermogenesis, and that nephrectomized animals have lower core temperature; in these circumstances, it is quite probable that hypothermia might occur due to renal disease. Additionally, in an experimental study, hypothermia has been found to induce ultrastructural changes in renal tubular cells and these changes were similar to acute tubular necrosis .…”

Section: Discussionmentioning

confidence: 99%

Prognostic Factors and a Prognostic Index for Cats with Acute Kidney Injury

Lee

Chan²,

Hsu

et al. 2012

Veterinary Internal Medicne

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Background:The clinical manifestations of acute kidney injury (AKI) range from mild to fatal in cats; however, prognosis factors have been rarely studied.Hypothesis/Objectives: To find the clinical factors significantly correlated with the outcome among cats with AKI and to develop a simple prognostic index.Animals: Seventy cats with AKI were recruited. Methods: Demographic and clinicopathological data obtained from 70 cats with AKI were retrospectively collected. Student's t-test or Mann-Whitney U-test and Pearson chi-square test or Fisher's exact were applied to determine the factors associated with survival in cats with AKI. Using logistic regression, the statistically significant factors associated with prognosis were identified and a new prediction model was generated.Results: The overall case fatality rate was 64% (45/70). The results showed that nonsurviving cats had significantly lower levels of PCV, WBC, RBC, LDH and albumin, a lower albumin/globulin ratio, lower blood glucose, and a reduced body temperature, as well as being older. Serum urea and creatinine concentrations were not statistically significant as prognostic factors, but a decrease in these 2 variables in 3 days was significantly related to a reduction in death. A summary prognostic index including body temperature and LDH and albumin concentrations had area under the receiveroperating characteristic curve (AUROC) for predicting death of 0.86 (P < .05) and a cut-off value of 0.82, a sensitivity of 77% and a specificity of 90%.Conclusions: The prognosis in cats with AKI is quite different from that found for human and dogs.

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Section: Discussionmentioning

confidence: 99%

Prognostic Factors and a Prognostic Index for Cats with Acute Kidney Injury

Lee

Chan²,

Hsu

et al. 2012

Veterinary Internal Medicne

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“…As previously defined, the temperature register obeys a nonlinear and randomized model (24). Thus, by a chaotic solution to a deterministic equation, we mean a solution whose outcome is very sensitive to initial conditions and whose evolution through phase space appears to be quite random.…”

Section: Discussionmentioning

confidence: 99%

“…The role of the CNS has been demonstrated in the control of thermal and metabolic homeostasis in mammals (9,24). It is well known that thermal control pathways involve central and peripheral afferent nerve stimuli arriving into the hypothalamic preoptic area and efferent neural and humoral signaling control on thermogenesis and heat loss.…”

Section: Discussionmentioning

confidence: 99%

Early detection of metabolic and energy disorders by thermal time series stochastic complexity analysis

Lutaif

Palazzo

Gontijo

2014

Braz J Med Biol Res

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Maintenance of thermal homeostasis in rats fed a high-fat diet (HFD) is associated with changes in their thermal balance. The thermodynamic relationship between heat dissipation and energy storage is altered by the ingestion of high-energy diet content. Observation of thermal registers of core temperature behavior, in humans and rodents, permits identification of some characteristics of time series, such as autoreference and stationarity that fit adequately to a stochastic analysis. To identify this change, we used, for the first time, a stochastic autoregressive model, the concepts of which match those associated with physiological systems involved and applied in male HFD rats compared with their appropriate standard food intake age-matched male controls (n=7 per group). By analyzing a recorded temperature time series, we were able to identify when thermal homeostasis would be affected by a new diet. The autoregressive time series model (AR model) was used to predict the occurrence of thermal homeostasis, and this model proved to be very effective in distinguishing such a physiological disorder. Thus, we infer from the results of our study that maximum entropy distribution as a means for stochastic characterization of temperature time series registers may be established as an important and early tool to aid in the diagnosis and prevention of metabolic diseases due to their ability to detect small variations in thermal profile.

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“…The uniform body temperature in endothermic species is maintained by thermogenesis, which is directly related to the cellular metabolism . Experimental studies revealed that the kidney has a great contribution in thermoregulation . In fact, for more than 50 years, it has been recognized that only a small portion of the energy consumed by the kidneys is used for the ionic and molecular osmotic transfer …”

Section: Introductionmentioning

confidence: 99%

“…Lutaif et al revealed the important role of kidneys in the body thermoregulation. Their experiments were conducted with Sprague‐Dawley rats, which were subjected to surgeries to simulate renal insufficiency, like the bilateral renal denervation and the partial nephrectomy (renal mass reduction by ablation).…”

Section: Introductionmentioning

confidence: 99%

Estimation of the kidney metabolic heat generation rate

Orlande

Lutaif

Gontijo

2019

Numer Methods Biomed Eng

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Thermogenesis results from the cellular metabolism and has a fundamental role for body thermoregulation in endothermic species. The motivation for this work is the analysis of the kidneys' contribution for thermoregulation. An inverse problem is solved for the estimation of the heat generation rate that results from the metabolic activities in the kidney, by using transient temperature measurements of the urine. The Markov chain Monte Carlo (MCMC) method is applied for the solution of the inverse problem, which presents inherent difficulties associated with low sensitivity of the parameters of main interest that represent the transient heat source term and strong correlation of the remaining model parameters. Such difficulties are dealt with in this work by using a version of the Metropolis‐Hastings algorithm that samples the parameters in blocks. Simulated temperature measurements are used for the inverse problem solution, and the convergence of the Markov chains is verified with two different techniques.

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Renal contribution to thermolability in rats: role of renal nerves

Abstract: Speculatively, it may be suggested that one of the renal sensory nerve signal defects associated with decreased kidney energy generation, induced by kidney ablation, may result in an inability to control the body temperature.

Cited by 7 publications

References 35 publications

Prognostic Factors and a Prognostic Index for Cats with Acute Kidney Injury

Prognostic Factors and a Prognostic Index for Cats with Acute Kidney Injury

Early detection of metabolic and energy disorders by thermal time series stochastic complexity analysis

Estimation of the kidney metabolic heat generation rate

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