Renal Considerations in Angiotensin Converting Enzyme Inhibitor Therapy

Schoolwerth, Anton C.; Sica, Domenic A.; Ballermann, Barbara J.; Wilcox, Christopher S.

doi:10.1161/hc4101.096153

Cited by 311 publications

(99 citation statements)

References 70 publications

(62 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The current therapy for IgAN patients includes the use of blockers of the renin-angiotensinogen system and steroids, 24,25 which can result in several side-effects, particularly after longterm use (e.g., decreased kidney function, anemia, hypotension, osteoporosis, and steroid dependency). 26,27 This issue hampers the general utilization of these therapies.…”

Section: Discussionmentioning

confidence: 99%

The Role of TNF Superfamily Member 13 in the Progression of IgA Nephropathy

Han¹,

Yang

Choi

et al. 2016

JASN

View full text Add to dashboard Cite

TNF superfamily member 13 (TNFSF13) has been identified as a susceptibility gene for IgA nephropathy in recent genetic studies. However, the role of TNFSF13 in the progression of IgA nephropathy remains unresolved. We evaluated two genetic polymorphisms (rs11552708 and rs3803800) and plasma levels of TNFSF13 in 637 patients with IgA nephropathy, and determined the risk of ESRD according to theses variable. Neither of the examined genetic polymorphisms associated with a clinical outcome of IgA nephropathy. However, high plasma levels of TNFSF13 increased the risk of ESRD. To explore the causal relationship and underlying mechanism, we treated B cells from patients (n=21) with or without recombinant human TNFSF13 (rhTNFSF13) and measured the expression of IgA and galactose-deficient IgA (GdIgA) using ELISA and flow cytometry. Treatment with rhTNFSF13 significantly increased the total IgA level among B cells, and TNFSF13 receptor blockade abrogated this increase. Furthermore, the absolute levels of GdIgA increased with rhTNFSF13 treatment, but the total IgA-normalized levels did not change. Both RNA sequencing and quantitative PCR results showed that rhTNFSF13 did not alter the expression of glycosyltransferase enzymes. These results suggest that high plasma TNFSF13 levels associate with a worse prognosis of IgA nephropathy through the relative increase in GdIgA levels.

show abstract

Section: Discussionmentioning

confidence: 99%

The Role of TNF Superfamily Member 13 in the Progression of IgA Nephropathy

Han¹,

Yang

Choi

et al. 2016

JASN

View full text Add to dashboard Cite

show abstract

“…The deleterious effect of ACE inhibition on glomerular filtration rate (GFR) in patients with bilateral renal artery stenosis is well recognized (22,23). It has been proposed that candidates for ACE inhibitor therapy be screened for occult ARAS before therapy (24,25).…”

Section: <0014mentioning

confidence: 99%

Angiotensin-Converting Enzyme Inhibitor Usage in Patients with Incidental Atherosclerotic Renal Artery Stenosis

Yang

et al. 2004

Hypertens Res

View full text Add to dashboard Cite

“…24 Although there are no standard guidelines used to interpret changes in serum creatinine, 50% rise from baseline, an increase of 0.5 mg/dL (40 μmol/L) or more when baseline serum creatinine is <2 mg/dL (180 μmol/L), or an increase of 1 mg/dL (90 μmol/L) or more if baseline creatinine is >2 mg/dL have been used as biochemical criteria of ARF. [26][27][28] At the first sign of renal dysfunction, the patient's medication list should be reviewed to identify offending agents. If multiple medications are present and the patient is clinically stable, physicians should start by discontinuing the drug most recently added to the patient's medication regimen.…”

Section: Recognition and Early Interventionmentioning

confidence: 99%