Renal concentrating mechanism of the squirrel monkey

Ee, Selkurt; Wathen, RL

doi:10.1152/ajplegacy.1967.213.1.191

Cited by 9 publications

(1 citation statement)

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“…However, the difference might just as well be due to the diluting effect of a larger reabsorption of water from the collecting ducts in water diuresis than in hydropenia (Kiil and Aukland 1960, 1961, Aukland and Kjekshus 1966. Selkurt and Wathen (1967) observed that Pitressin administration to squirrel monkeys did not influence the washout of solutes from the renal medulla during mannitol diuresis. They concluded that "it seems highly unlikely that Pitressin has a constrictive effect on the medullary circulation out of proportion to its total effect on renal circulation", but again, the conclusion is based on the assumption that medullary solute concentration is mainly determined by blood flow.…”

Section: Discussionmentioning

confidence: 89%

Vasopressin and Intrarenal Blood Flow Distribution

Aukland

1968

Acta Physiologica Scandinavica

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AUKLAND, K. Vasopressin and intrarenal bloodflow distribution. Acta physiol. scand. 1968. 74. 173~182.It has been suggested that the rise in urine osmolality produced by antidiuretic hormone is wholly or partly due to juxtamedullary vasoconstriction with reduction of medullary blood flow. This hypothesis was tested in 10 hydrated dogs in Nembutal anesthesia. Effective renal blood flow (ERBF) was estimated by p-aminohippurate clearance, and medullary blood flow by hydrogen gas clearance from the outer medulla measured polarographically with needle-shaped platinum electrodes. I.v, infusion of Pitressin, 3-120 mU/hr per kg body weight, or synthetic lysin-vasopressin, 2.5-30 mU/hr per kg, on average increased urine osmolality from 100 to 500 rrrOsmjkg. Arterial blood pressure rose slightly with doses higher than 20-30 m'Ujhr per kg. ERBF and outer medullary hydrogen clearance was not changed by 1-2 hrs vasopressin infusion, and also remained unchanged during return to water diuresis after stopping vasopressin. The experiments thus showed no effect of vasopressin either on total renal perfusion or on medullary blood flow.

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Section: Discussionmentioning

confidence: 89%