Renal collecting (Bellini) duct carcinoma displays similar characteristics to upper tract urothelial cell carcinoma

Orsola, Anna; Trias, Isabel; Raventós, Carles X.; Español, Ignacio; Rosell, L. Cecchini; Orsola, I.

doi:10.1016/j.urology.2004.08.012

Cited by 65 publications

(41 citation statements)

References 17 publications

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“…Results of staining for markers of the distal nephron should be interpreted with caution as expression of cytokeratin AE1/AE3 and Ulex Europeaus agglutinin-1 has been reported in high-grade urothelial carcinoma arising from the renal papilla and exhibiting adjacent carcinoma in situ. 19 Recently immunoexpression of transmembrane enzyme complex carbonic anhydrase IX has been shown to differentiate urothelial carcinoma (diffuse to multifocal strong membrane staining in 90% of cases) from collecting-duct carcinoma (scanty, focal and weak membrane staining in 60% of cases). Survival data from case reports and small case series indicates that these tumors have a poor prognosis.…”

Section: Collecting-duct Carcinomamentioning

confidence: 99%

Uncommon and recently described renal carcinomas

2009

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Major consensus conferences held over a decade ago laid the foundations for the current (2004) WHO classification of renal carcinoma. Clear cell, papillary and chromophobe carcinomas account for 85-90% carcinomas seen in routine practice. The remaining 10-15% of carcinomas consist of rare sporadic and hereditary tumors, some of which had been long recognized, but many of which only emerged as distinct entities in the decade leading up to the WHO publication. Collecting-duct carcinoma is a rare, often lethal form of carcinoma. Medullary carcinoma associated with sickle cell trait, has emerged as a distinctive tumor showing some overlapping features with upper tract urothelial carcinoma. Mucinous tubular and spindle-cell carcinoma and tubulocystic carcinoma were earlier considered as patterns of low-grade collecting-duct carcinoma, but are now recognized as separate tumor entities. Carcinomas associated with somatic translocations of TFE3 and TFEB comprise a significant proportion of pediatric renal carcinomas. Oncocytoid renal carcinomas in neuroblastoma survivors was recognized as a unique tumor category in the WHO classification. Renal carcinoma associated with end-stage renal disease is now recognized as having distinct morphological patterns and behavior. In addition there is a group of rare recently described carcinomas, including clear cell papillary carcinoma, oncocytic papillary renal cell carcinoma, follicular renal carcinoma and leiomyomatous renal cell carcinoma. It behooves the surgical pathologist to not only be capable of diagnosing the common forms of renal cancer, but also to be aware of the rare types of renal carcinoma, many of which have emerged in recent years.

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Section: Collecting-duct Carcinomamentioning

confidence: 99%

Uncommon and recently described renal carcinomas

2009

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“…In the report published by Milowsky et al (4), a patient with T4N2M0 CDC was treated with RN plus adjuvant chemotherapy (doxorubicin + gemcitabine) and survived for 10 months post-surgery. Furthermore, Orsola et al (5) reported two cases (T4N1M0 and T3aN1M0) who received the same treatment as the patient described by Milowsky et al (4); however, the mean survival time was only 5.6 months post-surgery (5). Chao et al (10) described two stage T3aN0M1 CDC cases, both of whom were treated with RN plus adjuvant chemotherapy (paclitaxel + carboplatin); the patients succumbed to CDC 9 and 17 months post-surgery, respectively.…”

Section: Discussionmentioning

confidence: 93%

“…However, since CDC is diagnosed based on pathological examination, surgery is thus inevitable in the majority of such cases. To the best of our knowledge, the majority of patients with CDC that present at an advanced stage will succumb to the disease within one year post-surgery, regardless of whether they receive or deny adjuvant therapies (1)(2)(3)(4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Surgical monotherapy may be a suitable therapeutic strategy for advanced collecting (Bellini) duct carcinoma: A case report and literature review

Zhu

Wang

Pan

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Collecting duct carcinoma (CDC), which is also known as Bellini duct carcinoma, accounts for less than 1% of all renal cell carcinoma, which has a poor prognosis. Predominantly, clinicians recognize this disease due to past experience and case reports, and a standard treatment is yet to be established. The present case report describes a 57-year-old male patient with CDC who was successfully treated with a left laparoscopic radical nephrectomy without any adjuvant therapy and compares the present patient's clinical presentation with previously reported cases. By analyzing the differences between these cases, the findings of the present case report and literature review suggested that surgery alone remains the only suitable choice for patients with advanced CDC.

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“…This oncogene is also occasionally associated with clear cell RCC (Orsola et al, 2005). Renal dysplasia is a developmental aberration characterized by cells undergoing active proliferation and programmed cell death in a deregulated manner, and this process has been reported to involve the paired box gene 2 (PAX2), paired box gene 8 (PAX8), Wilms tumor 1 (WT1), and B-cell lymphoma 2 (BCL2) genes (Orsola et al, 2005). Normally there is cooperation between p53 and Bcl2 to protect the cell.…”

Section: Discussionmentioning

confidence: 99%

Nephrotoxic and Prooncogenic Effects of Monosodium Glutamate in Quail (Coturnix japonica)

Solcan¹,

Costachescu²,

Fotea³

et al. 2018

PVJ

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The study aims to assess the effect of monosodium glutamate (MSG) in Japanese quail (Coturnix japonica). It was done on one hundred and thirty-four quails were divided into four groups: one control group (C) and three experimental groups that received during 30 days a daily dose of 10 g (E1), 30 g (E2) and 50 g (E3) MSG/kg feed, respectively. It was noticed to the end of the experiment an improvement in growth performance for the group E1, while in groups E2 and E3 higher feed consumption and decreased average daily weight gain was observed. Hematological studies revealed significant changes for the groups E2 (decreased PCV, reduction of Hf/Lf ratio, due to heterophils decrease) and E3 (increased Hf/Lf ratio due to heterophils increase and lymphocytes reduction) compared to the control group (C). Hematobiochemical studies revealed significant increases in blood urea nitrogen (BUN), creatinine and uric acid in quails from E2 and E3. In the kidneys of birds from E2 and E3 birds, was observed a degradation of cortical and medullar cytoarchitecture and also necrosis and vacuolization of proximal and distal convoluted tubules cells were observed. Positive nuclei were showed by P53 staining, both in proximal and distal convoluted tubules, collecting tubules epithelium but also in some of Malpighi corpuscles. Bcl-2 revealed positivity in the cytoplasm of the proximal and distal convoluted tubules cells in varying proportions depending on the group suggesting the prooncogenic potential of MSG in dosages that exceed 30g/kg feed.

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Renal collecting (Bellini) duct carcinoma displays similar characteristics to upper tract urothelial cell carcinoma

Cited by 65 publications

References 17 publications

Uncommon and recently described renal carcinomas

Uncommon and recently described renal carcinomas

Surgical monotherapy may be a suitable therapeutic strategy for advanced collecting (Bellini) duct carcinoma: A case report and literature review

Nephrotoxic and Prooncogenic Effects of Monosodium Glutamate in Quail (Coturnix japonica)

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