Renal clearances during prolonged supine exercise at different loads

Grimby, Gunnar

doi:10.1152/jappl.1965.20.6.1294

Cited by 118 publications

(61 citation statements)

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“…In contrast to responses at 25.60 C where hepatic-splanchnic blood flow falls with exercise at about 25 % of maximal oxygen intake, this fall was initiated by even the mildest exercise at 43.3°C (3). Renal blood flow diminished also (6,24). Whereas a greater fraction of the cardiac output undoubtedly is distributed to skin, the addition of highly unsaturated venous blood from splanchnic and other regions to arterialized blood from cutaneous veins undoubtedly accounted for the similarity of mixed a-v oxygen differences in the two environments at 49 to 58%o of maximal oxygen consumption.…”

Section: Discussionmentioning

confidence: 74%

Reductions in cardiac output, central blood volume, and stroke volume with thermal stress in normal men during exercise.

Rowell¹,

Marx²,

Bruce³

et al. 1966

J. Clin. Invest.

221

164

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Section: Discussionmentioning

confidence: 74%

Reductions in cardiac output, central blood volume, and stroke volume with thermal stress in normal men during exercise.

Rowell¹,

Marx²,

Bruce³

et al. 1966

J. Clin. Invest.

221

164

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“…Decreased renal blood flow is a potent stimulus to renin secretion (Ekblom et al, 1968;Laragh and Sealey, 1973), and reduced renal blood flow during strenuous exercise has been confirmed by many workers (Chapman et al, 1948;Grimby, 1965). Alphaadrenergically mediated renal vasoconstriction (Beveglrd and Shepherd, 1967;Grimby, 1965;Rowell, 1971) and fluid shifts in extrarenal vascular beds, which result in plasma volume contraction during acute exercise (Astrand, 1976;Astrand and Saltin, 1964;Clement and Shepherd, 1976;Mellanders et al, 1967), largely account for the fall in renal blood flow. The close correlations between changes in hematocrit and plasma protein concentration and changes in PRA are consistent with the view that exercise-induced intravascular volume contraction is an important factor influencing renin secretion during exercise.…”

Section: Discussionmentioning

confidence: 95%

Effects of exercise on plasma viscosity in athletes and sedentary normal subjects

Letcher

Pickering

Chien

et al. 1981

Clinical Cardiology

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Summary:To assess the immediate and long-term effects of exercise on factors regulating blood flow, we measured plasma viscosity (qP) and plasma renin activity (PRA) in 17 trained runners and 16 sedentary healthy subjects before and 10 min after graded treadmill exercise. Resting vP was lower in runners primarily because of significantly lower fibrinogen concentration. Compared to nonrunners with similar 24-h urine electrolyte excretion rates, runners were characterized by lower PRA at rest. In view of the overall correlation between heart rate and PRA before exercise, reduced adrenergic tone was probably a major factor contributing to the lower PRA in runners. After exercise, plasma viscosity and PRA exceeded control levels, and were similar in magnitude in runners and sedentary subjects. Changes in plasma viscosity were less than expected from the degree of hemoconcentration, primarily because enhanced fibrinolysis maintained fibrinogen level constant. To the extent that plasma viscosity affects viscous flow resistance, the results suggest that tissue perfusion and oxygen delivery rate at rest are greater in trained runners than in sedentary subjects, but these variables become similar after maximum exertion.

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“…In the cal exercise does not affect glomerular filtration rate (GFR) remaining 11 cases (Group II) there were no changes in and renal excretory function in normal subjects. 5,8,[13][14][15] Howthese parameters. Renal perfusion significantly deever, no study has been reported in patients with decompencreased in both groups although the reduction was sated cirrhosis.…”

mentioning

confidence: 99%

“…8 When physical exercise is intense (ú7 METs) there is a decrease in GFR, free-water DISCUSSION clearance, urine volume, and sodium excretion. [5][6][7][8][13][14][15] Filtration fraction increases, 15 indicating that renal vasoconstricPhysical exercise in healthy subjects is associated with mation occurs predominantly in the efferent arterioles. The jor changes in endogenous vasoactive systems, systemic and mechanisms leading to the reduction in renal perfusion and regional hemodynamics, and respiratory function.…”

mentioning

confidence: 99%

“…42 Because NO is also a potent vasodilator of the there is no decrease in GFR and renal excretory function. [5][6][7][8][13][14][15] In fact, a modest but significant increase in GFR, renal circulation, 43 it may be speculated that an impaired synthesis of NO may also contribute to exercise-induced renal urine volume, and sodium excretion has been reported by some investigators. 8,13,27 impairment in patients with cirrhosis and ascites.…”

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confidence: 99%

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Impairment of renal function during moderate physical exercise in cirrhotic patients with ascites: Relationship with the activity of neurohormonal systems

et al. 1997

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The treatment of ascites in cirrhosis is based on sodium Moderate physical exercise does not affect glomerular restriction and the administration of diuretics. Bed rest is filtration rate (GFR) and renal excretory function in noralso frequently recommended because the assumption of an mal subjects. This study is aimed at assessing the effects upright posture from supine by patients with ascites is associof moderate physical exercise on renal function in 21 ated with marked stimulation of the renin-aldosterone and nonazotemic cirrhotic patients with ascites. Arterial sympathetic nervous systems and decreased response to dipressure, heart rate, and renal function were assessed uretics. [1][2][3][4] Moderate physical exercise in normal subjects and in the patients after 2 hours in the supine position and in patients with cirrhosis and ascites is also associated with during 30 minutes of moderate cycloergometric exercise significant stimulation of the renin-aldosterone and sympain the sitting position. The activity of the renin-aldosthetic nervous systems. [5][6][7][8][9][10] The mechanism of this, however, terone and sympathetic nervous systems and the plasma is different from that occurring during postural changes. levels of antidiuretic hormone (ADH) and atrial natriWhereas postural changes affect neurohormonal vasoactive uretic peptide (ANP) were determined at the end of each systems through a baroreceptor-mediated mechanism, the period. Physical exercise induced a marked reduction effect of physical exercise is mediated by a central command in GFR (75 { 10 to 49 { 6 mL/min), free-water clearance from brain structures and peripheral muscle mechano-and (6.1 { 1 to 3.4 { 1 mL/min), and sodium excretion (7.8 { chemoreflexes. 11,12 It is well established that moderate physi-2 to 4.3 { 1 mEq/min) in 10 patients (Group I). In the cal exercise does not affect glomerular filtration rate (GFR) remaining 11 cases (Group II) there were no changes in and renal excretory function in normal subjects. 5,8,[13][14][15] Howthese parameters. Renal perfusion significantly deever, no study has been reported in patients with decompencreased in both groups although the reduction was sated cirrhosis. If physical exercise induced a deterioration greater in Group I (034.7% { 4.6% vs. 07.5% { 3.1%, P õ of renal function in these patients, it would further support .001). Physical exercise was associated with a significant bed rest as a therapeutic measure for ascites, especially in and comparable increase in arterial pressure, heart rate, patients responding poorly to diuretics. and plasma levels of renin, aldosterone, and norepinephTherefore, the aim of the current study is to assess the rine (NE) in the two groups of patients. The ANP conceneffect of moderate physical exercise on renal plasma flow, tration did not change. Patients from Groups I and II GFR, free-water clearance, and urinary sodium excretion in differed significantly (P õ .05) only in plasma renin accirrhotic patients with ascites. tivity (PRA) and NE concentration, which...

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Renal clearances during prolonged supine exercise at different loads

Cited by 118 publications

References 0 publications

Reductions in cardiac output, central blood volume, and stroke volume with thermal stress in normal men during exercise.

Reductions in cardiac output, central blood volume, and stroke volume with thermal stress in normal men during exercise.

Effects of exercise on plasma viscosity in athletes and sedentary normal subjects

Impairment of renal function during moderate physical exercise in cirrhotic patients with ascites: Relationship with the activity of neurohormonal systems

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