Renal Clearance of Eighteen Individual Amino Acids in Human Subjects 1

Doolan, Paul D.; Harper, Harold A.; Hutchin, Maxine E.

doi:10.1172/jci103171

Cited by 64 publications

(15 citation statements)

References 18 publications

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“…The amino acids dividuals. These results agree qualitatively with frequently found excreted in high amounts in nor-those of other workers (17)(18)(19)28). t The standard deviation of the mean.…”

Section: Normal Fasting Values In the Body Fluidssupporting

confidence: 89%

Studies of Unbound Amino Acid Distributions in Plasma, Erythrocytes, Leukocytes and Urine of Normal Human Subjects

McMenamy¹,

Lund²,

Neville³

et al. 1960

J. Clin. Invest.

102

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Section: Normal Fasting Values In the Body Fluidssupporting

confidence: 89%

Studies of Unbound Amino Acid Distributions in Plasma, Erythrocytes, Leukocytes and Urine of Normal Human Subjects

McMenamy¹,

Lund²,

Neville³

et al. 1960

J. Clin. Invest.

102

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“…In a previous study (1) it was observed that the clearance of cystine increased during the infusion of an amino acid mixture in the absence of any increase in filtered load of cystine. The infusion mixture is virtually free of cystine (lot B-27 contains 0.09 ,M per ml.).…”

Section: Resultsmentioning

confidence: 90%

“…The experimental protocol is outlined in Table I-A, the rate of infusion being calculated on a basis of its glycine content. The glomerular filtration rate (GFR) was meas- 1 The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Navy Department or the Naval Service at large. 2Lieutenant Commander, Medical Corps, United States Navy.…”

Section: Methodsmentioning

confidence: 99%

“…ured by means of inulin clearance and the manner in which the blood and urine specimens were collected was the same as that used in previous studies (1). The designation "high load" is an arbitrary one, meaning not only that the infusion was given at a faster rate but in addition, in the case of the first three experiments, that the amino acid mixture was supplemented with additional glycine.…”

Section: Methodsmentioning

confidence: 99%

“…95.5 kg. )-received glycine alone, as outlined in Table I-B. The methods employed for the microbiological assays of the individual amino acids and the exact composition of the amino acid solution used, as determined in this laboratory (lot B-27), have been reported (1,2). The statistical analysis of the data in which each individual's control period measurements were available was made by means of the 't' test for paired data.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

The Renal Tubular Response to Amino Acid Loading 1

Doolan¹,

Harper²,

Hutchin³

et al. 1956

J. Clin. Invest.

Self Cite

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In previous studies from this laboratory (1) it was shown that renal tubular reabsorption of filtered amino acids was virtually complete in the fasting state. However, when a solution of amino acids was administered intravenously and the load filtered by the kidney thus increased, both the amounts of amino acids reabsorbed and those excreted were increased. In quantitative terms the more noteworthy event was the increase in amount reabsorbed. Considerable selectivity was exhibited in the reabsorption of individual amino acids and evidence was obtained which was interpreted as indicating a "competition" for reabsorption between cystine and one or more other amino acids.In the present studies the solution of amino acids used for loading was administered at a faster rate than in the previously reported experiments and it was supplemented with additional glycine to test the effects of a further increase in the filtered load of amino acids. In separate studies glycine was administered alone and, in terms of amounts reabsorbed and excreted, the results were compared with those obtained when glycine was given as part of the amino acid mixture and comparable filtered loads were achieved. METHODSThree normal subjects-DNW (age 21, ht. 184.2 cm., wt. 85.5 kg.), WRR (age 28, ht. 175.3 cm., wt. 95.0 kg.), and WS (age 29, ht. 168.9 cm., wt. 60.5 kg.)-were given Merck's 10 per cent solution of free amino acids. The experimental protocol is outlined in Table I-A, the rate of infusion being calculated on a basis of its glycine content. The glomerular filtration rate (GFR) was meas-

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Evaluation of Amino-Aciduria in Infancy and Childhood

Ghadimi¹,

Shwachman²

1960

Arch Pediatr Adolesc Med

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Renal Clearance of Eighteen Individual Amino Acids in Human Subjects 1

Cited by 64 publications

References 18 publications

Studies of Unbound Amino Acid Distributions in Plasma, Erythrocytes, Leukocytes and Urine of Normal Human Subjects

Studies of Unbound Amino Acid Distributions in Plasma, Erythrocytes, Leukocytes and Urine of Normal Human Subjects

The Renal Tubular Response to Amino Acid Loading 1

Evaluation of Amino-Aciduria in Infancy and Childhood

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