Renal clearable nanoparticles: An expanding horizon for improving biomedical imaging and cancer therapy

Mosleh-Shirazi, Sareh; Abbasi, Milad; Shafiee, Mostafa; Kasaee, Seyed Reza; Amani, Ali Mohammad

doi:10.1016/j.mtcomm.2021.102064

Cited by 33 publications

(21 citation statements)

References 150 publications

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“…For instance, insulin with a hydrodynamic size of approximately 3 nm can be totally excreted through the urinary system with 100% filtering performance. However, the neutral-charge surface modification could also help proper renal excretion of NPs with a hydrodynamic size of approximately 6–8 nm [ 24 ], due to sensitivity of the glomerular endothelial wall to the neutral surface charge of NPs [ 25 ]. In our study, after irradiation, the gold nanoclusters on the surface gradually turned into free small gold nanoparticles of 5–8 nm.…”

Section: Results and Discussionmentioning

confidence: 99%

“Petal-like” size-tunable gold wrapped immunoliposome to enhance tumor deep penetration for multimodal guided two-step strategy

Song

et al. 2021

J Nanobiotechnol

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Background Breast cancer is the fastest-growing cancer among females and the second leading cause of female death. At present, targeted antibodies combined with hyperthermia locally in tumor has been identified as a potential combination therapy to combat tumors. But in fact, the uniformly deep distribution of photosensitizer in tumor sites is still an urgent problem, which limited the clinical application. We reported an HER2-modified thermosensitive liposome (immunoliposome)-assisted complex by reducing gold nanocluster on the surface (GTSL-CYC-HER2) to obtain a new type of bioplasma resonance structured carrier. The HER2 decoration on the surface enhanced targeting to the breast cancer tumor site and forming irregular, dense, "petal-like" shells of gold nanoclusters. Due to the good photothermal conversion ability under near-infrared light (NIR) irradiation, the thermosensitive liposome released the antitumor Chinese traditional medicine, cyclopamine, accompanied with the degradation of gold clusters into 3–5 nm nanoparticles which can accelerate renal metabolism of the gold clusters. With the help of cyclopamine to degrade the tumor associated matrix, this size-tunable gold wrapped immunoliposome was more likely to penetrate the deeper layers of the tumor, while the presence of gold nanoparticles makes GTSL-CYC-HER2 multimodal imaging feasible. Results The prepared GTSL-CYC-HER2 had a size of 113.5 nm and displayed excellent colloidal stability, photo-thermal conversion ability and NIR-sensitive drug release. These GTSL-CYC-HER2 were taken up selectively by cancer cells in vitro and accumulated at tumour sites in vivo. As for the in vivo experiments, compared to the other groups, under near-infrared laser irradiation, the temperature of GTSL-CYC-HER2 rises rapidly to the phase transition temperature, and released the cyclopamine locally in the tumor. Then, the released cyclopamine destroyed the stroma of the tumor tissue while killing the tumor cells, which in turn increased the penetration of the liposomes in deep tumor tissues. Moreover, the GTSL-CYC-HER2 enhanced the performance of multimodal computed tomography (CT) and photothermal (PT) imaging and enabled chemo-thermal combination therapy. Conclusions This optically controlled biodegradable plasmonic resonance structures not only improves the safety of the inorganic carrier application in vivo, but also greatly improves the anti-tumor efficiency through the visibility of in vivo CT and PT imaging, as well as chemotherapy combined with hyperthermia, and provides a synergistic treatment strategy that can broaden the conventional treatment alone. Graphic Abstract

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Section: Results and Discussionmentioning

confidence: 99%

“Petal-like” size-tunable gold wrapped immunoliposome to enhance tumor deep penetration for multimodal guided two-step strategy

Song

et al. 2021

J Nanobiotechnol

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“…The route of administration, exposure time and pharmacokinetics also influence toxicity ( Stensberg et al, 2011 ; Aboelmaati et al, 2021 ; Mosleh-Shirazi et al, 2021a ). Therefore, it remains to be investigated whether the gradual release of Ag + and the broad spectrum of antimicrobial activity of AgNPs may lead to changes in the normal microbiota of humans and animals and whether this may have adverse effects over time.…”

Section: Toxicitymentioning

confidence: 99%

“…Among the various metals, silver has a long history in medicine as an antimicrobial agent ( Rai et al, 2009 ). Currently, silver nanoparticles (AgNPs) occupy a prominent place as potential antifungal agents for clinical use due to their broad spectrum of antimicrobial activity and their enormous number of applications in the health sciences, ranging from topical formulations to catheters impregnated with AgNPs ( Rai et al, 2009 ; Ahamed et al, 2010 ; Burdușel el et al, 2018 ; Mosleh-Shirazi et al, 2021a ).…”

Section: Introductionmentioning

confidence: 99%

Biogenic silver nanoparticles as antifungal agents

Mussin

Giusiano

2022

Front. Chem.

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In recent years, an increase in multidrug-resistant fungal strains has been observed, which, together with the limited number of clinically available antifungal agents, highlights the need for the development of new antifungal agents. Due to the proven antifungal activity of silver nanoparticles (AgNPs), there is a growing interest in their use in the treatment of fungal infections. Nanoparticles are usually synthesised through a variety of physical and chemical processes that are costly and pollute the environment. For this reason, biogenic synthesis is emerging as an environmentally friendly technology and new strategies are increasingly based on the use of biogenic AgNPs as antifungal agents for clinical use. The aim of this review is to compare the antifungal activity of different biogenic AgNPs and to summarise the current knowledge on the mechanisms of action and resistance of fungi to AgNPs. Finally, a general analysis of the toxicity of biogenic AgNPs in human and veterinary medicine is performed.

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“…But the treatment of a tumor tissue demands dealing with plenty of limitations that urge the increasing interest in the use of Nanomaterials. Over the last decade, increased knowledge of the microenvironment of tumors has motivated our efforts to develop nanoparticles as a novel cancer-related therapeutic and diagnostic strategy 2 . Cancer tissues consist of non-cellular (e.g.…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology Advances in the Detection and Treatment of Cancer: An Overview

Mosleh-Shirazi¹,

Abbasi²,

Moaddeli³

et al. 2022

Nanotheranostics

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Over the last few years, progress has been made across the nanomedicine landscape, in particular, the invention of contemporary nanostructures for cancer diagnosis and overcoming complexities in the clinical treatment of cancerous tissues. Thanks to their small diameter and large surface-to-volume proportions, nanomaterials have special physicochemical properties that empower them to bind, absorb and transport high-efficiency substances, such as small molecular drugs, DNA, proteins, RNAs, and probes. They also have excellent durability, high carrier potential, the ability to integrate both hydrophobic and hydrophilic compounds, and compatibility with various transport routes, making them especially appealing over a wide range of oncology fields. This is also due to their configurable scale, structure, and surface properties. This review paper discusses how nanostructures can function as therapeutic vectors to enhance the therapeutic value of molecules; how nanomaterials can be used as medicinal products in gene therapy, photodynamics, and thermal treatment; and finally, the application of nanomaterials in the form of molecular imaging agents to diagnose and map tumor growth.

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Renal clearable nanoparticles: An expanding horizon for improving biomedical imaging and cancer therapy

Cited by 33 publications

References 150 publications

“Petal-like” size-tunable gold wrapped immunoliposome to enhance tumor deep penetration for multimodal guided two-step strategy

“Petal-like” size-tunable gold wrapped immunoliposome to enhance tumor deep penetration for multimodal guided two-step strategy

Biogenic silver nanoparticles as antifungal agents

Nanotechnology Advances in the Detection and Treatment of Cancer: An Overview

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