Renal Changes in Malignant Hypertension

Wilson, Campbell; Byrom, F.B.

doi:10.1016/s0140-6736(00)41759-9

Cited by 50 publications

(33 citation statements)

References 7 publications

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“…In this study, male 2K1C rats were nearly twice as likely to develop hypertension compared with their female counterparts. A study using both male and female rats reported a success rate of inducing hypertension in clipped rats of 65 % [6], which was lower than the 78 % success rate when only male rats were used [7]. Given the findings of the present study, it is tempting to speculate that the lower success rate in the former study may reflect the inclusion of both sexes.…”

Section: Discussioncontrasting

confidence: 61%

A comparison of the development of renal hypertension in male and female rats

OKUNIEWSKI¹,

Davis²,

JARROTT³

et al. 1998

Clinical Science

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1. The objective of this study was to determine the influence of gender on the development of renal hypertension in Sprague-Dawley rats using the Goldblatt two-kidney, one-clip (2K1C) model. In addition, this study examined the effect of ovariectomy upon the development of hypertension in female rats.2. At 10 weeks of age, male, intact female and ovariectomized female rats underwent clipping of the right renal artery or sham operation. Tail-cuff plethysmography was used to monitor the systolic blood pressure of all animals for 7 weeks post-clipping or sham operation. Rats were sub-grouped according to whether or not they developed hypertension (systolic blood pressure >=150 mmHg).3. Within 2 to 3 weeks of clipping, hypertension was induced in only 53% (n=120) of the intact female 2K1C rats, but in 83% (n=18) of the male and 78% (n=18) of the ovariectomized female rats.4. Seven weeks after right renal artery clipping, plasma renin activity was determined in a subset of each group and was found to be 5-6 fold higher in male (17.29+/-4.04 ng angiotensin I.h-1.ml-1) and ovariectomized female (9.71+/-1.25 ng angiotensin I.h-1.ml-1) hypertensive rats compared with their respective normotensive or sham-operated counterparts (3.39+/-0.58 ng angiotensin I.h-1.ml-1 and 1.60+/-0.41 ng angiotensin I.h-1.ml-1 respectively) (P<0.05, analysis of variance). In contrast, the plasma renin activity measured in intact female hypertensive rats was not significantly different from that measured in the corresponding 2K1C normotensive or sham-operated groups.5. These results indicate that the success rate of inducing renal hypertension in Sprague-Dawley rats is higher in males than in intact females. Furthermore, these results suggest that the induction of 2K1C hypertension may be influenced by ovarian hormones.

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Section: Discussioncontrasting

confidence: 61%

A comparison of the development of renal hypertension in male and female rats

OKUNIEWSKI¹,

Davis²,

JARROTT³

et al. 1998

Clinical Science

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“…Early investigations in other vascular beds, notably the cerebral circulation [11][12][13], suggested a linkage between vascular myogenic capacity and protection against hypertensive injury. More recent investigations in the kidney led to similar conclusions, in that when blood pressure exceeds the autoregulatory range, vascular and glomerular injury result.…”

Section: Role Of Autoregulatory Mechanisms In Renal Protectionmentioning

confidence: 99%

Systolic blood pressure as the trigger for the renal myogenic response: protective or autoregulatory?

Loutzenhiser

Griffin²,

Bidani³

2006

Current Opinion in Nephrology &Amp; Hypertension

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“…Hypertension was induced by removing the left kidney and partially constricting the right renal artery with a silver clip of internal diameter of 0.25 mm (Wilson & Byrom, 1939). The clip was removed from the renal artery as described by Byrom & Dodson (1949) and Floyer (1951).…”

Section: Operative Proceduresmentioning

confidence: 99%

Changes in Body Fluid Distribution and Interstitial Tissue Compliance during the Development and Reversal of Experimental Renal Hypertension in the Rat

Lucas

Floyer

1974

Clinical Science

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1.To determine the part played by changes in interstitial tissue compliance in the mechanism of experimental renal hypertension, pressure and volume measurements were made in rats 60 days after partial constriction of one renal artery with a clip and removal of the opposite kidney. Tissue pressure and venous pressure were found to be significantly higher in rats which developed systolic arterial blood pressure of 140 mmHg or above than in loosely clipped controls with normal blood pressure. Plasma volume (PV) was also increased in the hypertensive animals, but there was no difference in interstitial fluid volume (IFV); the PV/IFV ratio was significantly higher in the hypertensive rats.2. Removal of the clip in the hypertensive rats restored blood pressure to normal in 1 h; this was associated with a fall in venous pressure and plasma volume. Tissue pressure fell despite a rise in interstitial fluid volume; the PV/IFV ratio fell.3. It is suggested that renal artery constriction, possibly by a humoral mechanism, causes a fall in interstitial space compliance and that this, by causing changes in body fluid distribution, plays a part in the mechanism of experimental renal hypertension. This mechanism may have a physiological role in the maintenance of adequate plasma volume during water shortage.The mechanism by which hypertension is sustained in the Goldblatt rat, in which one kidney is removed and the artery to the other is partially constricted, is still uncertain. Since blood levels of renin are raised soon after renal artery constriction, but fall to normal as the blood pressure

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Renal Changes in Malignant Hypertension

Cited by 50 publications

References 7 publications

A comparison of the development of renal hypertension in male and female rats

A comparison of the development of renal hypertension in male and female rats

Systolic blood pressure as the trigger for the renal myogenic response: protective or autoregulatory?

Changes in Body Fluid Distribution and Interstitial Tissue Compliance during the Development and Reversal of Experimental Renal Hypertension in the Rat

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