Renal cell carcinoma with solitary synchronous pancreaticoduodenal and metachronous periprostatic metastases: Report of a case

Yavaşçaoğlu, İsmet; Korun, Nusret; Oktay, Bülent; Şimşek, Ümit; Özyurt, Mustafa

doi:10.1007/bf02483065

Cited by 17 publications

(8 citation statements)

References 10 publications

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“…A total of 411 patients who underwent resection of pancreatic RCC metastases were described in 170 articles1, 2, 5–7, 14–178. Data for individual patients were not provided in ten reports containing a total of 100 patients27, 29, 63, 68, 75, 113, 119, 122, 159, 176.…”

Section: Methodsmentioning

confidence: 99%

Enabling Bifunctionality and Hemilability of N‐Heteroaryl NHC Complexes

Specht

Cortés-Llamas

Tran

et al. 2011

Chemistry A European J

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Background: This study examined the clinical outcome of patients with pancreatic metastases from renal cell carcinoma (RCC). Methods: A systematic literature search produced individual data for 311 surgically and 73 non‐surgically treated patients with pancreatic RCC metastases. A further ten patients underwent resection at the authors' institution. Results: In the resected group, pancreatic metastases were solitary in 65·3 per cent, symptomatic in 57·4 per cent, and were preceded and/or accompanied by extrapancreatic disease in 22·3 per cent. Respective values in the unresected group were 59, 60 and 58 per cent. Disease‐free survival rates were 76·0 and 57·0 per cent respectively at 2 and 5 years after resection, and overall survival rates were 80·6 and 72·6 per cent. The only significant risk factor for disease‐free survival after pancreatic resection was extrapancreatic disease (P = 0·001), and that for overall survival was symptomatic RCC metastasis (P = 0·031). Two‐ and 5‐year overall survival rates were 41 and 14 per cent respectively in unresected patients. Conclusion: The actuarial 5‐year overall survival rate following pancreatic surgery for RCC metastases was 72·6 per cent, as determined by pooled analysis from published series. Extrapancreatic disease was an independent risk factor for recurrence, but had no significant impact on overall survival. Copyright © 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

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Section: Methodsmentioning

confidence: 99%

Enabling Bifunctionality and Hemilability of N‐Heteroaryl NHC Complexes

Specht

Cortés-Llamas

Tran

et al. 2011

Chemistry A European J

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“…Metastatic tumors to the pancreas, excluding those involved with widespread disease or in direct continuity with the pancreas, are rare clinically and are exceedingly difficult to differentiate from a primary pancreatic neoplasm. When metastatic foci to the pancreas clinically manifest as mass lesions, lung, breast, colon, skin (melanoma), and kidney primary tumors are among the metastatic neoplasms that are found most frequently 1–58. Secondary involvement of the pancreas by metastatic renal cell carcinoma (RCC), especially in surgical pathology material, is rare.…”

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confidence: 99%

Renal cell carcinoma to the pancreas in surgical pathology material

Thompson

Heffess

2000

Cancer

175

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“…Intraluminal small bowel metastases from metastatic RCC are not commonly seen, but based on autopsied cases may have an incidence of 0.7%-14.6% [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. The interval from initial nephrectomy to presentation of intestinal metastases ranged from 3 months to 20 years, and appeared to correlate with overall disease-specific survival [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]19]. Intestinal metastases occur equally in the jejunum and the ileum and usually present with intestinal bleeding because of tumoral invasion of intestinal vessels [12] and/or intestinal obstruction.…”

Section: Discussionmentioning

confidence: 99%

“…Intussusceptions of the metastatic lesion causing obstruction have also been reported [1,2,4,5,20]. The majority of patients with intestinal RCC metastases also had pulmonary metastases, suggesting that the lung, via the pulmonary circulation, may be a key disseminating site for RCC metastases [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]21]. All patients presenting with intestinal metastases underwent surgery that resulted in complete resolution of abdominal symptoms.…”

Section: Discussionmentioning

confidence: 99%

A Case of Small Bowel Obstruction Due to Intraluminal Metastases from Metastatic Renal Cell Cancer

et al. 2008

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A 71-year-old man, with a history of metastatic renal cell cancer (RCC), presented with symptoms of a small bowel obstruction with nausea, vomiting, cramps, and diarrhea. He underwent surgery and was found to have intraluminal metastases from his metastatic RCC. Intraluminal metastases are rare and usually present with obstruction, bleeding, or perforation. The mainstay of treatment remains complete surgical excision, even in the face of widely metastatic disease. Surgery not only palliates symptoms, but may also extend survival because metastatic RCC can be a very indolent and unpredictable disease. Furthermore, these patients can now be treated with a new class of antiangiogenic agents that are showing impressive response rates, which may also translate into improved overall survival. The Oncologist 2008;13:95-97 CASEA 71-year-old man presented to the emergency room (ER) with nausea, vomiting, abdominal cramps, weight loss, and diarrhea. Seven years earlier he was diagnosed with renal cell carcinoma (RCC) and had a right nephrectomy. The tumor invaded the renal vein, inferior vena cava, hilar lymph nodes, right adrenal gland, and the renal vein resection margin was positive. One year later, the tumor recurred in the renal vein stump and he underwent a caval resection. He remained well for 3 years, at which point routine surveillance showed asymptomatic lung and liver metastases, and 1 year later small bowel metastases. Because he was clinically well he received no systemic treatment and was stable for 3 years until his presentation to the ER.Clinical examination revealed tenderness on deep palpation in the epigastric region. Laboratory findings were normal except for a mild normocytic anemia, and hyponatremia. Abdominal computed tomography scan (Fig. 1) demonstrated marked dilatation of the small intestine (4 cm diameter) and the presence of a 3.9 cm ϫ 3.4 cm, hypervascular mass 30 cm proximal to the terminal ileum. The mass had intraluminal, mural, and extraluminal components with large draining veins. Distal to the mass, the small intestine was collapsed. Progression of liver metastases was also noted.The patient underwent a laparoscopic-assisted small bowel resection, which revealed a metastatic nodule involving the mucosa, small bowel wall, and subserosal fat (Fig. 2). The tumor was composed of polygonal cells

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Renal cell carcinoma with solitary synchronous pancreaticoduodenal and metachronous periprostatic metastases: Report of a case

Cited by 17 publications

References 10 publications

Enabling Bifunctionality and Hemilability of N‐Heteroaryl NHC Complexes

Enabling Bifunctionality and Hemilability of N‐Heteroaryl NHC Complexes

Renal cell carcinoma to the pancreas in surgical pathology material

A Case of Small Bowel Obstruction Due to Intraluminal Metastases from Metastatic Renal Cell Cancer

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