Renal cell carcinoma revealed by sternal tumefaction: A rare case report and literature review

Imran, Mohamed; Mhanna, Tarik; Aynaou, Mohammed; Ouraghi, Abdelghani; Alaoui, Mhammedi Wassim; Barki, Ali

doi:10.1016/j.eucr.2020.101137

Cited by 3 publications

(7 citation statements)

References 5 publications

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“…The post-biopsy pathological analysis indicated a renal cell carcinoma as the originating tumour that was complicated by this isolated metastasis. Further targeted therapy was offered to this 76-year-old male [ 100 ].…”

Section: Discussionmentioning

confidence: 99%

“…Overall, we identified 14 studies (of more than 1 subject/article) [ 18 , 20 , 21 , 22 , 24 , 51 , 53 , 64 , 66 , 70 , 72 , 73 , 74 , 75 ] and 34 single case reports [ 14 , 15 , 16 , 17 , 19 , 23 , 25 , 26 , 38 , 41 , 42 , 43 , 47 , 52 , 55 , 56 , 59 , 60 , 62 , 68 , 71 , 76 , 77 , 78 , 89 , 98 , 99 , 100 , 101 , 102 ] within our methods with respect to sternal metastases (n = 48 papers) ( Table 5 ).…”

Section: Discussionmentioning

confidence: 99%

“… Overview of published case reports (N = 34) according to our methods [ 14 , 15 , 16 , 17 , 19 , 23 , 25 , 26 , 30 , 32 , 33 , 37 , 38 , 41 , 42 , 43 , 47 , 52 , 55 , 56 , 59 , 60 , 62 , 68 , 71 , 76 , 77 , 78 , 89 , 98 , 99 , 100 , 101 , 102 ]. Abbreviations: N = number of patients; MiNEN = mixed neuroendocrine–non-neuroendocrine tumour.…”

Section: Figurementioning

confidence: 99%

“…Table 5. Single case reports of sternal metastases according to our methods; the articles are cited starting with the most recent time of publication [14][15][16][17]19,23,25,26,30,32,33,37,38,[41][42][43]47,52,55,56,59,60,62,68,71,[76][77][78]89,[98][99][100][101][102]. The case we mentioned brought up the importance of addressing a sternal biopsy into the larger frame of multi-lined, complex management.…”

Section: A 43-month Sample-based Study: a Heterogeneous Picturementioning

confidence: 99%

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Sternum Metastases: From Case-Identifying Strategy to Multidisciplinary Management

Carsote,

Terzea,

Vasilescu

et al. 2023

Diagnostics

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We aimed to overview the most recent data on sternal metastases from a multidisciplinary approach (diagnosis strategies, outcome, and histological reports). This narrative review based on a PubMed search (between January 2020 and 22 July 2023) using key words such as “sternal”, “manubrium”, and “metastasis” within the title and/or abstract only included original papers that specifically addressed secondary sternal spreading of cancer in adults, for a total of 48 original articles (14 studies and 34 single case reports). A prior unpublished case in point is also introduced (percutaneous incisional biopsy was used to address a 10 cm sternal tumour upon first admission on an apparently healthy male). The studies (n = 14) may be classified into one of three groups: studies addressing the incidence of bone metastases (including sternum) amid different primary cancers, such as prostate cancer (N = 122 with bone metastases, 83% of them with chest wall metastases), head and neck cancers (N = 3620, 0.8% with bone metastases, and 10.34% of this subgroup with sternum involvement); and glioblastoma (N = 92 with bone metastases, 37% of them with non-vertebral metastases, including the sternum); assessment cohorts, including breast cancer (N = 410; accuracy and sensitivity of PET/CT vs. bone scintigraphy is superior with concern to sternum spreading) and bone metastases of unknown origin (N = 83, including a subgroup with sternum metastases; some features of PET/CT help the differentiation with multiple myeloma); and cohorts with various therapeutic approaches, such as palliative arterial embolization (N = 10), thymic neuroendocrine neoplasia (1/5 detected with sternum metastases), survival rates for sternum metastases vs. non-sternum chest wall involvement (N = 87), oligo-metastatic (sternal) breast cancer (3 studies, N = 16 for all of them), oligo-metastatic head and neck cancer (N = 81), conformal radiotherapy (N = 24,215, including an analysis on sternum spreading), and EBRT followed by MR-HIFU (N = 6). Core data coming from the isolated case reports (N = 34) showed a female to male ratio of 1.6; the females’ ages were between 34 and 80 (mean of 57.28) and the males’ ages varied between 33 and 79 (average of 58.78) years. The originating tumour profile revealed that the most frequent types were mammary (N = 8, all females) and thyroid (N = 9, both women and men), followed by bladder (N = 3), lung (N = 2), and kidney (N = 2). There was also one case for each of the following: adenoid cystic carcinoma of the jaw, malignant melanoma, caecum MiNEN, a brain and an extracranial meningioma, tongue carcinoma, cholangiocarcinoma, osteosarcoma, and hepatocellular carcinoma. To our knowledge, this is the most complex and the largest analysis of prior published data within the time frame of our methods. These data open up new perspectives of this intricate, dynamic, and challenging domain of sternum metastases. Awareness is a mandatory factor since the patients may have a complex multidisciplinary medical and/or surgical background or they are admitted for the first time with this condition; thus, the convolute puzzle will start from this newly detected sternal lump. Abbreviations: N = number of patients; n = number of studies; PET/CT = positron emission tomography/computed tomography; EVRT = external beam radiotherapy; MR-HIFU = magnetic resonance-guided high-intensity focused ultrasound; MiNEN = mixed neuroendocrine-non-neuroendocrine tumour.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: A 43-month Sample-based Study: a Heterogeneous Picturementioning

confidence: 99%

See 2 more Smart Citations

Sternum Metastases: From Case-Identifying Strategy to Multidisciplinary Management

Carsote,

Terzea,

Vasilescu

et al. 2023

Diagnostics

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“…Dual-energy multidetector CT has improved the ability to differentiate clear-cell and papillary cell carcinomas, by using virtual noncontrast imaging, and iodine quantification maps. 18…”

Section: Imaging Featuresmentioning

confidence: 99%

Up, Up, and Above—Tumor Thrombus in RCC

Periaswamy,

Christopher,

Arunachalam

et al. 2023

Indographics

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Intravascular tumor thrombosis is most commonly encountered in renal cell carcinoma (RCC), which alters the staging and prognosis of malignancies, indicating an advanced stage of malignancy, which can be surgically challenging during treatment course. Imaging plays a vital role in the detection of tumor thrombus and in differentiating it from bland thrombus. The Mayo Clinic thrombus classification is widely used to describe levels of inferior vena cava tumor thrombus (IVC-TT) in patients with locally advanced RCC. In this article, we review the classification, guidelines, and recent diagnostic tools for RCC with IVC tumor thrombi, and mention about the various surgical approaches for each stage of tumor thrombi.

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