Renal Cell Carcinoma of Variant Histology: New Biologic Understanding Leads to Therapeutic Advances
Nicholas J. Salgia,
Zeynep B. Zengin,
Sumanta K. Pal
et al.
Abstract:Renal cell carcinoma (RCC) is one of the 10 most commonly diagnosed solid tumors. Most RCCs are histologically defined as clear cell, comprising approximately 75% of diagnoses. However, the remaining RCC cases are composed of a heterogeneous combination of diverse histopathologic subtypes, each with unique pathogeneses and clinical features. Although the therapeutic approach to both localized and metastatic RCCs has dramatically changed, first with the advent of antiangiogenic targeted therapies and more recen… Show more
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