Renal Cell Carcinoma of the Native Kidney: A Frequent Tumor After Kidney Transplantation With Favorable Prognosis in Case of Early Diagnosis

Végsô, Gyula; Toronyi, É.; Hajdú, Melinda; Piros, László; Görög, Dénes; Deák, Pál Ákos; Doros, Attila; Peter, A. G. M. De Smet; Langer, Róbert

doi:10.1016/j.transproceed.2011.03.068

Cited by 24 publications

(17 citation statements)

References 15 publications

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“…In the general population, ccRCC and papillary RCC comprise about 70% and 10-15% of RCC cases, respectively (8). In contrast, recent studies indicate an overrepresentation of papillary RCCs among kidney recipients, typically reported to comprise more than 30% of cases (14,23-26). Most prior studies were small (i.e., they included fewer than 50 RCCs in recipients) and were based at single institutions (14,23,25,26).…”

Section: Discussionmentioning

confidence: 86%

“…In contrast, recent studies indicate an overrepresentation of papillary RCCs among kidney recipients, typically reported to comprise more than 30% of cases (14,23-26). Most prior studies were small (i.e., they included fewer than 50 RCCs in recipients) and were based at single institutions (14,23,25,26). Our study, which is much larger, confirms that papillary RCCs are overrepresented in kidney transplant recipients (28% of our cases), and it provides the first SIR estimate quantifying the markedly elevated risk for this subtype.…”

Section: Discussionmentioning

confidence: 86%

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Risk of Renal Cell Carcinoma Among Kidney Transplant Recipients in the United States

Karami

Yanik

Moore

et al. 2016

American Journal of Transplantation

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Renal cell carcinoma (RCC) is a common malignancy following kidney transplantation. We describe RCC risk and examine RCC risk factors among US kidney recipients (1987-2010). The Transplant Cancer Match Study links the US transplant registry with 15 cancer registries. Standardized incidence ratios (SIRs) were used to compare RCC risk (overall and for clear cell [ccRCC] and papillary subtypes) to the general population. Associations with risk factors were assessed using Cox models. We identified 683 RCCs among 116,208 kidney recipients. RCC risk was substantially elevated compared with the general population (SIR 5.68, 95%CI 5.27-6.13), especially for papillary RCC (SIR 13.3 vs. 3.98 for ccRCC). Among kidney recipients, RCC risk was significantly elevated for blacks compared to whites (hazard ratio [HR] 1.50) and lower in females than males (HR 0.56). RCC risk increased with prolonged dialysis preceding transplantation (p-trend<0.0001). Risk was variably associated for RCC subtypes with some medical conditions that were indications for transplantation: ccRCC risk was reduced with polycystic kidney disease (HR 0.54), and papillary RCC was increased with hypertensive nephrosclerosis (HR 2.02) and vascular diseases (HR 1.86). In conclusion, kidney recipients experience substantially elevated risk of RCC, especially for papillary RCC, and multiple factors contribute to these cancers.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 86%

Risk of Renal Cell Carcinoma Among Kidney Transplant Recipients in the United States

Karami

Yanik

Moore

et al. 2016

American Journal of Transplantation

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“…In our series, the most frequent subtype was clear cell RCC. In the evaluation of 43 RCCs in the native kidneys of patients who received kidney transplants in Budapest, Hungary, the predominant histological type was clear cell RCC [22]. In a multi-institutional study from Italy and Spain that analyzed the outcomes of RCC in patients with end-stage renal disease, clear cell RCC was similarly the most frequent subtype; and ACKD-associated RCC was not identified at all [23].…”

Section: Distribution Of Rcc Morphotypes In Hungarymentioning

confidence: 99%

Prognostic Factors for Renal Cell Carcinoma Subtypes Diagnosed According to the 2016 WHO Renal Tumor Classification: a Study Involving 928 Patients

Kuthi

Jenei

Hajdu

et al. 2016

Pathol. Oncol. Res.

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The morphotype and grade of renal cell carcinoma (RCC) in 928 nephrectomies were reclassified according to the 2016 WHO classification in order to analyze the distribution and outcomes of RCC subtypes in Hungary, to assess whether microscopic tumor necrosis is an independent prognostic factor in clear cell RCC, and to study whether a two-tiered grading (low/high) for clear cell and papillary RCC provides similar prognostic information to that of the four-tiered ISUP grading system. 83.4% of the cohort were clear cell, 6.9% papillary, 4.5% chromophobe, 2.3% unclassified, 1.1% Xp11 translocation, 1.1% clear cell papillary, 0.3% collecting duct and 0.1% mucinous tubular and spindle cell RCCs. RCC occurred in 16 patients with end-stage kidney disease and none of them displayed features of acquired cystic kidney disease-associated RCC. The 5-year survival rates were as follows: chromophobe 100%, clear cell papillary 100%, clear cell low-grade 96%, papillary type 1 92%, clear cell high-grade 63%, papillary type 2 65%, unclassified 46%, Xp11 translocation 20%, and collecting duct 0%. The 5-year survival rates in low-grade and high-grade papillary RCC were 95% and 59%, respectively. In clear cell RCC, only the grade, the stage and the positive surgical margin proved to be independent prognostic factors statistically. Overall, papillary RCC occurred relatively infrequently; microscopic tumor necrosis in clear cell RCC did not predict the outcome independently of the tumor grading; and the assignment of clear cell and papillary RCCs into low-grade or high-grade tumors was in terms of survival no worse than the ISUP grading.

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“…In particular, kidney TRs show a three-to-eightfold increased risk to develop a malignancy, mainly non-melanoma skin cancers (particularly squamous cell carcinoma) [9] and lymphoproliferative disorders, especially non-Hodgkin lymphoma [10]. Renal cancer of the native kidney, mainly clear cell and papillary renal cell carcinomas, has been described previously in the context of a renal transplant, with an incidence quoted as 0.35-3.9% [11]. Acquired renal cystic disease and long-term dialysis are considered to be the main risk factors [12,13].…”

Section: Discussionmentioning

confidence: 99%

Advanced native-kidney carcinoma in a heart- and kidney-transplanted patient: a case report

et al. 2018

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Malignancies are one of the leading causes of death in long-term surviving transplant recipients. Dose and prolonged durations of immunosuppressive regimens are considered the main cause, through a direct oncogenic effect and a renowned interaction on physiological anti-viral and anti-oncogenic immune response. Specific neoplasms are known to occur with different frequencies according to the transplanted organ. As a consequence, imaging screenings have been implemented in many graft surveillance programs, although a wide consensus on the timing and modality has not been concurred. There are little data available in the literature regarding incidence of de-novo malignancies in multi-organ recipients. We report the case of a 66-year-old man who developed a renal mass 10 years after a combined heart-kidney transplant.

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Renal Cell Carcinoma of the Native Kidney: A Frequent Tumor After Kidney Transplantation With Favorable Prognosis in Case of Early Diagnosis

Cited by 24 publications

References 15 publications

Risk of Renal Cell Carcinoma Among Kidney Transplant Recipients in the United States

Risk of Renal Cell Carcinoma Among Kidney Transplant Recipients in the United States

Prognostic Factors for Renal Cell Carcinoma Subtypes Diagnosed According to the 2016 WHO Renal Tumor Classification: a Study Involving 928 Patients

Advanced native-kidney carcinoma in a heart- and kidney-transplanted patient: a case report

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