Renal cell carcinoma occurring in a child 2 years after chemotherapy for neuroblastoma.

Fenton, Douglas S.; Taub, Jeffrey W.; Amundson, G M; Padiyar, Niru; Cushing, Barbara

doi:10.2214/ajr.161.1.8517297

Cited by 27 publications

(9 citation statements)

References 5 publications

(1 reference statement)

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“…Another 12 cases of renal cell carcinoma associated with neuroblastoma have now been reported in the literature. 12,[15][16][17]26,27 The cytogenetic and microsatellite PCR analyses performed on the four oncocytoid renal cell carcinomas reported by Medeiros et al 30 revealed abnormalities not usually described in other known types of renal cell carcinoma. In accordance, absence of TFE3 overexpression, MSI, and VHL alterations in our study support the concept of these carcinomas as a distinct clinicopathologic entity now included in the new WHO classification.…”

Section: Discussionmentioning

confidence: 93%

Morphologic and Molecular Characterization of Renal Cell Carcinoma in Children and Young Adults

Bruder¹,

Passera²,

Harms³

et al. 2004

American Journal of Surgical Pathology

240

193

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A new WHO classification of renal cell carcinoma has been introduced in 2004. This classification includes the recently described renal cell carcinomas with the ASPL-TFE3 gene fusion and carcinomas with a PRCC-TFE3 gene fusion. Collectively, these tumors have been termed Xp11.2 or TFE3 translocation carcinomas, which primarily occur in children and young adults. To further study the characteristics of renal cell carcinoma in young patients and to determine their genetic background, 41 renal cell carcinomas of patients younger than 22 years were morphologically and genetically characterized. Loss of heterozygosity analysis of the von Hippel-Lindau gene region and screening for VHL gene mutations by direct sequencing were performed in 20 tumors. TFE3 protein overexpression, which correlates with the presence of a TFE3 gene fusion, was assessed by immunohistochemistry. Applying the new WHO classification for renal cell carcinoma, there were 6 clear cell (15%), 9 papillary (22%), 2 chromophobe, and 2 collecting duct carcinomas. Eight carcinomas showed translocation carcinoma morphology (20%). One carcinoma occurred 4 years after a neuroblastoma. Thirteen tumors could not be assigned to types specified by the new WHO classification: 10 were grouped as unclassified (24%), including a unique renal cell carcinoma with prominently vacuolated cytoplasm and WT1 expression. Three carcinomas occurred in combination with nephroblastoma. Molecular analysis revealed deletions at 3p25-26 in one translocation carcinoma, one chromophobe renal cell carcinoma, and one papillary renal cell carcinoma. There were no VHL mutations. Nuclear TFE3 overexpression was detected in 6 renal cell carcinomas, all of which showed areas with voluminous cytoplasm and foci of papillary architecture, consistent with a translocation carcinoma phenotype. The large proportion of TFE3 "translocation" carcinomas and "unclassified" carcinomas in the first two decades of life demonstrates that renal cell carcinomas in young patients contain genetically and phenotypically distinct tumors with further potential for novel renal cell carcinoma subtypes. The far lower frequency of clear cell carcinomas and VHL alterations compared with adults suggests that renal cell carcinomas in young patients have a unique genetic background.

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Section: Discussionmentioning

confidence: 93%

Morphologic and Molecular Characterization of Renal Cell Carcinoma in Children and Young Adults

Bruder¹,

Passera²,

Harms³

et al. 2004

American Journal of Surgical Pathology

240

193

View full text Add to dashboard Cite

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“…Second malignancies after neuroblastoma described up to now were malignant tumors of the parotid [14], kidney cell carcinoma [15], osteogenic sarcoma [16], carcinoma and adenoma of the thyroid gland [17], acute lymphoblastic leukemia [8], and myelodysplastic syndrome and its transition to acute myelogenous leukemia [18].…”

Section: Discussionmentioning

confidence: 99%

Non-Hodgkin lymphoma (NHL) as a second neoplasm occurring after neuroblastoma treatment

Siegert

Weissbach

Fischer

et al. 1998

Med. Pediatr. Oncol.

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“…The link to radiation and radiotherapy is well established for thyroid malignancies and almost certainly develops as a consequence of therapeutic irradiation in these cases. The link between solid tumors and chemotherapy is not as well established, yet the literature contains at least one report of a secondary renal cell carcinoma arising in child whose only therapies were surgical extirpation and chemotherapy for neuroblastoma [23]. In the future, additional reports of second solid malignancies due to chemotherapy seem inevitable, as survival from pediatric neoplasms improves.…”

Section: Discussionmentioning

confidence: 99%

Anaplastic renal cell carcinoma following neuroblastoma

Krigman

Bentley

Strickland

et al. 1995

Med. Pediatr. Oncol.

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Renal cell carcinoma is unusual in children. We report a case of anaplastic renal cell carcinoma arising in a 7-year-old girl following treatment for Stage III neuroblastoma. The renal cell carcinoma has unusual histologic and ultrastructural features, which are discussed. The case is further unusual in that few children with advanced stage neuroblastoma survive long enough to develop second malignant neoplasms.

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Renal cell carcinoma occurring in a child 2 years after chemotherapy for neuroblastoma.

Cited by 27 publications

References 5 publications

Morphologic and Molecular Characterization of Renal Cell Carcinoma in Children and Young Adults

Morphologic and Molecular Characterization of Renal Cell Carcinoma in Children and Young Adults

Non-Hodgkin lymphoma (NHL) as a second neoplasm occurring after neuroblastoma treatment

Anaplastic renal cell carcinoma following neuroblastoma

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