Renal Cell Carcinoma Metastatic to the Pancreas: Clinical and Radiological Features

Ghavamian, Reza; Klein, Katherine A.; Stephens, David H.; Welch, Timothy J.; LeRoy, Andrew J.; Richardson, Ronald L.; Burch, Patrick A.; Zincke, Horst

doi:10.4065/75.6.581

Cited by 143 publications

(72 citation statements)

References 19 publications

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“…Hyperenhancement on CT scan following the administration of intravenous contrast was found to be a distinguishing feature of metastatic RCC on one of the earliest case series we reviewed [10]. This has since been refined by reports from a number of other institutions-for example, metastatic lesions are best viewed during the early phases of three-phase helical CT [41], and more lesions are detected on arterial than on portal venous phase imaging [42].…”

Section: Discussionmentioning

confidence: 96%

“…Of these, 4 featured patient populations that overlapped with subsequent, larger studies, and 12 were rejected because they did not fulfil the inclusion criteria. The remaining 18 studies met the above criteria to merit inclusion in the extractable and analysable dataset [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. The search strategy and outcomes are summarised in Figure 1.…”

Section: Search Yields and Data Retrievalmentioning

confidence: 99%

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Pancreatectomy for metastatic disease: A systematic review

Adler

Redmond

Heneghan

et al. 2014

European Journal of Surgical Oncology (EJSO)

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Aim: Tumours rarely metastasise to the pancreas. While surgical resection of such metastases is believed to confer a survival benefit, there is limited data to support such management. We present a systematic review of case series of pancreatic metastasectomy and analysis of survival outcomes.Methods: A literature search was performed using the PubMed and Cochrane databases and the reference lists of relevant articles, searching for sizeable case series of pancreatic metastasectomy with curative intent. Data extracted included basic demographics, histological primary tumour, presentation, operative management, complications and survival, while the MINORS index was used to assess study quality.Results: 18 studies were found which met our inclusion criteria, involving 399 patients. Renal cell carcinoma (RCC) was the commonest malignancy metastasising to the pancreas, responsible for 62.6% of cases, followed by sarcoma (7.2%) and colorectal carcinoma (6.2%). While survival data was not uniformly reported, the median survival post-metastasectomy was 50.2 months, with a oneyear survival of 86.81% and five-year survival of 50.02%. Median survival for RCC was 71.7 months with 70.4% five-year survival. Median survival was similar in patients with synchronous and metachronous pancreatic metastases, but patients with additional extrapancreatic metastases had a significantly shorter survival than patients with isolated pancreatic metastases (26 versus 45 months). Study quality was poor, with a median MINORS score of 10/16. Conclusions:Within the limitations of a review of non-randomised case series, it would appear that pancreatic metastasectomy confers a survival benefit in selected patients. Better evidence is required, but may prove difficult to acquire. Key words:pancreatic metastasis, metastasectomy, pancreatectomy, metastatic renal cell cancer, 3 Introduction:

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Section: Discussionmentioning

confidence: 96%

Section: Search Yields and Data Retrievalmentioning

confidence: 99%

Pancreatectomy for metastatic disease: A systematic review

Adler

Redmond

Heneghan

et al. 2014

European Journal of Surgical Oncology (EJSO)

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“…20,21 Best results are obtained if the metastases are pulmonary, metachronous, with a long disease-free interval, and completely resected. 22 Other small series have reported encouraging results following the excision of hepatic, adrenal, brain, and pancreatic metastases, [23][24][25][26][27] or of isolated local recurrences in the nephrectomy bed. 28,29 Circumstances where patients can undergo resection of residual disease after response to systemic therapy may indeed become more common with the higher tumor shrinkage rates of novel agents described herein.…”

Section: Role Of Cytoreductive Nephrectomy In Advanced Diseasementioning

confidence: 98%

Recent Progress in the Management of Advanced Renal Cell Carcinoma

García

Rini

2007

CA: A Cancer Journal for Clinicians

162

116

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“…To our knowledge this is the second case described in the literature, the first being described in 2011 by Cenkowski et al [7]. In general, metastases to the pancreas are rare phenomena and renal cell carcinoma is the most common primary tumor metastasizing to this organ [8,9,10]. According to Hung et al, from a total of 329 cases of resected secondary malignancy of the pancreas, RCC was the primary site of origin in 73.9% of cases, with a median interval of 108 months (9 years) between resection of a primary tumor and metastasis.…”

Section: Discussionmentioning

confidence: 77%

Renal cell carcinoma metastasizing to pancreatic neuroendocrine neoplasm – the second case described in the world literature

Bednarek-Rajewska¹,

Zalewski²,

Breborowicz³

et al. 2017

pjp

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Tumor-to-tumor metastases are very rare events. We report a case of a 64-year-old man who presented with a tumor of the pancreas. The patient underwent partial pancreatectomy. Frozen section diagnosis of the tumor was an endocrine neoplasm. Paraffin block slide examination revealed a tumor consisting of two components: pancreatic endocrine neoplasm at the periphery of the tumor and the central part composed of clear cells with delicate vessels. The results of immunohistochemical stains revealed renal cell carcinoma surrounded by pancreatic endocrine neoplasm, therefore representing an unusual case of renal cell carcinoma metastasizing to a pancreatic endocrine neoplasm.Key words: tumor-to-tumor metastasis, renal cell carcinoma metastasizing to pancreatic endocrine neoplasm.

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Renal Cell Carcinoma Metastatic to the Pancreas: Clinical and Radiological Features

Cited by 143 publications

References 19 publications

Pancreatectomy for metastatic disease: A systematic review

Pancreatectomy for metastatic disease: A systematic review

Recent Progress in the Management of Advanced Renal Cell Carcinoma

Renal cell carcinoma metastasizing to pancreatic neuroendocrine neoplasm – the second case described in the world literature

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