Renal Cell Carcinoma Metastatic to the Ovary

Udoji, Esther; Herts, Brian R.

doi:10.1016/j.juro.2012.05.022

Cited by 2 publications

(4 citation statements)

References 9 publications

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“…In one case, ovarian metastasis was detected eight years before the primary tumor [12]. Fuhrman grade was mentioned in 11 cases, including our case, four of them being grade 2, six grade 3, and a single case grade 4 with sarcomatoid features [7,24,29,30,33-34].…”

Section: Reviewmentioning

confidence: 90%

“…Regarding the presenting symptoms, 11 patients were asymptomatic with metastasis found on scheduled postoperative imaging. Seven patients presented with an abdominal mass [7,8,10,16,22,32], four with weight loss [7,11,13,34], three with vaginal bleeding [10,12,19], two with fever [14,20], two with irregular menses [18,21], two with an abdominal distension [11,26], two with ascites [8,15], abdominal pain [20,36], weight gain [15], fatigue [13], weakness [14], shortness of breath [8,36], pelvic pain [26], generalized malaise and decreased energy [30], flank pain [34], bone fracture [24], and thyroid metastasis [16]. In 26 patients, ovarian metastases were detected three months to 21 years after kidney involvement.…”

Section: Reviewmentioning

confidence: 99%

“…A patient started treatment with interleukin-2 and continued with a high dose of sunitinib after recurrence. Due to a lack of response, the regimen was altered to everolimus, resulting in no disease progression [30]. In one case, the patient received three cycles of chemotherapy with no further specification [21].…”

Section: Reviewmentioning

confidence: 99%

“…Ovarian metastasis is usually part of generalized disease with several patients also having metastases to other organs prior to, concurrently, or after ovarian involvement. The most frequent metastatic sites were, by descending order, bone in five cases [7,10,17,24,30], lung in four cases [7,13,24], abdomen in four cases [10,13,22,30], adrenal glands in three cases [27,34], skin in two cases [18,22], muscle in two cases [20,34], thyroid in two cases [9,16], brain in two cases [9,18]; and one metastasis to each of the following organs: parotid [18], liver [34], gallbladder [29], vagina [12], and cervical, pelvic, and paraaortic lymph nodes [7,16,22]. In 12 cases, the ovary was the sole metastatic lesion described.…”

Section: Reviewmentioning

confidence: 99%

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Kidney Carcinoma Ovarian Metastasis: Review of the Literature

Koufopoulos

Nasi

Antoniadou

et al. 2018

Cureus

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Ovarian metastasis is common with secondary tumors representing up to 15% of ovarian neoplasms. The malignancies most commonly involving the ovaries are carcinomas of the stomach, colon, breast, endocervix, endometrium, and lymphoma. Secondary ovarian involvement by kidney carcinoma occurs very rarely and is usually associated with widespread dissemination.We conducted a review of kidney carcinoma with ovarian metastasis in the literature using the keywords clear cell renal cell carcinoma, papillary renal cell carcinoma, chromophobe renal cell carcinoma collecting duct carcinoma, and ovarian metastasis on Google Scholar and PubMed indices in April 2018, including a case diagnosed in our department. To date, 30 articles presenting 41 cases of kidney carcinoma with ovarian metastasis are reported in the literature. All reviewed cases were analyzed for diagnosis, surgical and systemic therapy, and outcome.Diagnosis may sometimes be challenging, requiring appropriate immunohistochemical markers in difficult cases. A combination of surgery and adjuvant therapy offers significant benefit in disease control or palliation of symptoms. Due to inconsistency in the reported data, further studies are needed to make safe conclusions regarding survival.

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Section: Reviewmentioning

confidence: 90%

Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

See 2 more Smart Citations

Kidney Carcinoma Ovarian Metastasis: Review of the Literature

Koufopoulos

Nasi

Antoniadou

et al. 2018

Cureus

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Renal cell carcinoma metastatic to the ovary or fallopian tube: a clinicopathological study of 9 cases

et al. 2016

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Renal cell carcinoma (RCC), the most common type of kidney cancer in adult, rarely metastasizes to the ovary or fallopian tube, and most cases published in the literature were case reports. Herein, we describe the clinicopathologic features of 9 cases of RCC metastatic to the ovary (n=8) or the fallopian tube (n=1). The patients’ age at the onset of primary renal tumor was available in 8 patients, ranging from 37 to 73 years (mean, 51 years; median, 50 years). Ovarian metastasis was detected prior to or concurrently with the primary renal tumors in 3 patients, and after the diagnosis of renal tumors in 6 patients. The histotypes of the RCCs were clear cell (n=7), chromophobe (n=1), and unclassified (n=1). Immunohistochemical stainings were performed on the sections containing metastatic tumors in 4 cases. Interestingly, pagetoid intraepithelial spread in the tubal mucosa was observed in the case of RCC metastatic to the fallopian tube. Among the 8 patients with follow-up data, 5 patients died of disease and 3 were alive with disease with a follow-up period ranging from 3.7 months to 17 years (mean, 77 months; median, 53 months) after the diagnosis of primary kidney tumors. Diagnostically, metastatic RCC may mimic primary ovarian tumors clinically, morphologically or immunophenotypically. Pathologists should also keep in mind that both ovarian and kidney tumors express PAX8 and PAX2, the markers commonly used to diagnosis metastatic RCC. In addition, chromophobe RCC only rarely metastasizes, but it can be a diagnosis challenging when metastasizing to the ovary.

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Renal Cell Carcinoma Metastatic to the Ovary

Cited by 2 publications

References 9 publications

Kidney Carcinoma Ovarian Metastasis: Review of the Literature

Kidney Carcinoma Ovarian Metastasis: Review of the Literature

Renal cell carcinoma metastatic to the ovary or fallopian tube: a clinicopathological study of 9 cases

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