Renal cell carcinoma metastasis to the parotid gland

Abstract

invasion at. He underwent radical nephrectomy and the Case report pathological examination revealed a 4×4×5 cm left lower-pole renal tumour with no invasion of the renal A 52-year-old man was admitted with macroscopic haematuria; on CT he had a 4 cm mass at the lower capsule, vein and perinephric fat; the histological diagnosis was RCC. Five months later the patient presented pole of the left kidney and no evidence of extrarenal with a 6×5×2 cm pre-auricular and a 1×0.5×0.5 cm postauricular mass. Abdominal and thoracic CT, and a bone scan, showed no metastases. The right neck was dissected and the pre-and postauricular masses excised. The pre-auricular mass was a RCC metastasis to the parotid gland ( Fig. 1) and the postauricular mass a lymph node metastasis, with extra metastatic lymph nodes in the neck. At a recent follow-up, the patient had multiple metastases, i.e. para-aortic, inguinal and cervical.

Metastatic Renal Cell Carcinoma to the Parotid Gland Presenting 19 years after Nephrectomy: Case report and Review of Literature

“…Although the most common sites for RCC metastasis are the lung, lymph nodes, bone, liver, adrenal and brain, this neoplasm may involve any organ including the parotid as an unusual metastatic site [1,2] It is well-described in the literature to metastasize to regions in the head and neck. In a case series of 65 patients with RCC presenting as metastatic lesion to the head and neck, 47 patients had cervical lymphadenopathy, and 18 patients presented at extranodal sites including the skin, thyroid, skull, pharynx, and lip, with no case in the parotid gland [3].…”

Renal Cell Carcinoma: Delayed Metachronous Metastases to Parotid and Cerebellum

“…15,[33][34][35][36][37] Within the head and neck, metastases of RCC to the parotid are even less common, with approximately 28 reported cases thus far in the literature. [7][8][9][10][11][12][13][14][15][16][17][19][20][21][22][38][39][40] At rare occasions, metastatic disease has been the initial presenting symptom and the reason the primary tumor was identified. 8,18,22,41 In all reported cases of metastatic RCC to the parotid gland, the most common presenting symptom was a painless mass with or without facial paralysis and, less often, neurosensory disturbances.…”

“…Involvement of the parotid has been reported most commonly along with widely spread disease, whereas only 28 cases of solitary involvement have been reported thus far. [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] Most of these cases are late presentations, several years after treatment of the primary tumor. In contrast, brain metastases from RCC are reported early in the course of the disease process, within the first 1 to 2 years, with an incidence up to 17%.…”

Renal clear cell carcinoma metastasis to salivary glands – a series of 9 cases: clinico-pathological study

“…Since the initial report of Patey et al [16], 46 cases with a predominance of parotid gland metastases have been published [14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46]. Among them, two reports contained detailed and full reviews of the literature [14,46].…”