Renal Cell Carcinoma Induces Prostaglandin E2 and T-Helper Type 2 Cytokine Production in Peripheral Blood Mononuclear Cells

Smyth, Gordon; Stapleton, Philip P.; Barden, Catherine B.; Mestre, Juan R.; Freeman, Tracy A.; Duff, Michael; Maddali, Sirish; Yan, Zhihui; Daly, J.M.

doi:10.1245/aso.2003.06.036

Cited by 41 publications

(25 citation statements)

References 34 publications

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“…25 Production of IL10, evidenced by elevated circulating levels, has been demonstrated by many solid tumors 26,27 including HNSCC, [28][29][30] ; however, some other reports have failed to show any rise. 13,31 These apparent discrepancies can potentially be explained by the tumor origin, which is often simply referred to as ''head and neck,'' despite the fact that marked differences exist between tumors of distinct primary sites.…”

Section: Discussionmentioning

confidence: 99%

Serum IL10 and circulating CD4⁺CD25^high regulatory T cell numbers as predictors of clinical outcome and survival in patients with head and neck squamous cell carcinoma

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Serum IL10 and circulating CD4⁺CD25^high regulatory T cell numbers as predictors of clinical outcome and survival in patients with head and neck squamous cell carcinoma

et al. 2011

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“…It has been reported that CM from kidney cancer cells or malignant melanoma cells enhanced the production of immunosuppressive cytokines such as IL-4, IL-6 and IL-10 by PBMCs (42,43). IL-10 is also known to be produced by PBMCs that are stimulated by OK-432 (44), followed by the inhibition of IFN-γ production (45).…”

Section: Discussionmentioning

confidence: 99%

Effect of soluble factors derived from oral cancer cells on the production of interferon-γ from peripheral blood mononuclear cells following stimulation with OK-432

et al. 2013

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Abstract. The streptococcal antitumor agent OK-432 is commonly used as an immunopotentiator for immunotherapy in various types of malignant tumors including oral cancer. It has been demonstrated that OK-432 elicits an antitumor effect by stimulating immunocompetent cells, thereby inducing multiple cytokines including interferon (IFN)-γ, interleukin (IL)-2 and IL-12. Serum concentrations of IFN-γ in patients with oral cancer were examined 24 h after administration of OK-432. Serum concentrations of IFN-γ in patients with advanced cancer were significantly lower than those in patients with early cancer. These results suggested that some soluble factors produced by cancer cells may inhibit IFN-γ production with OK-432. Thus, in the present study, an in vitro simulation model was established for the immune status of patients with oral cancer by adding conditioned medium (CM) derived from oral cancer cell lines into a culture of peripheral blood mononuclear cells (PBMCs) derived from a healthy volunteer. We investigated whether soluble factors derived from oral cancer cells affected IFN-γ production from PBMCs following stimulation with OK-432. PBMCs stimulated with OK-432 produced a large amount of IFN-γ; however, both IFN-γ production and cytotoxic activity from PBMCs induced by OK-432 were inhibited by the addition of CM in a dose-dependent manner. In order to examine these inhibitory effects against IFN-γ production, the contribution of inhibitory cytokines such as IL-4, IL-6, IL-10, transforming growth factor-β and vascular endothelial growth factor was investigated. However, neutralization of these inhibitory cytokines did not recover IFN-γ production inhibited by CM. These results indicated that unknown molecules may inhibit IFN-γ production from PBMCs following stimulation with OK-432.

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“…During progressive tumor growth, chronic inflammation caused by tumor-infiltrating immune cells contributes to cancer progression [231,295]. Oxidative stress seems to play a pivotal role in this process by stimulating an inflammatory network based on COX2, iNOS, cytokines, chemokines, and transcription factors.…”

Section: Inflammation and Cancer Escapementioning

confidence: 99%

Cancer Immunoediting: Elimination, Equilibrium, and Immune Escape in Solid Tumors

Wilczyński

Nowak

2013

Interaction of Immune and Cancer Cells

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Emphasizing the dynamic processes between cancer and host immune system, the initially discovered concept of cancer immunosurveillance has been replaced by the current concept of cancer immunoediting consisting of three phases: elimination, equilibrium, and escape. Solid tumors composed of both cancer and host stromal cells are an example of how the three phases of cancer immunoediting functionally evolve, and how a tumor shaped by the host immune system gets a finally resistant phenotype. Elimination, equilibrium, and escape are described in this chapter in detail, including the role of immune surveillance, cancer dormancy, disruption of the antigen-presenting machinery, tumor-infiltrating immune cells, and resistance to apoptosis, as well as the function of tumor stroma, microvesicles, exosomes and inflammation.

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Renal Cell Carcinoma Induces Prostaglandin E2 and T-Helper Type 2 Cytokine Production in Peripheral Blood Mononuclear Cells

Abstract: Human RCC inhibits the host antitumor immune response by promoting PGE(2) production and Th2 cytokines in PBMC. Selective inhibition of COX-2 may have a role in abrogating this effect.

Cited by 41 publications

References 34 publications

Serum IL10 and circulating CD4⁺CD25^high regulatory T cell numbers as predictors of clinical outcome and survival in patients with head and neck squamous cell carcinoma

Serum IL10 and circulating CD4⁺CD25^high regulatory T cell numbers as predictors of clinical outcome and survival in patients with head and neck squamous cell carcinoma

Effect of soluble factors derived from oral cancer cells on the production of interferon-γ from peripheral blood mononuclear cells following stimulation with OK-432

Cancer Immunoediting: Elimination, Equilibrium, and Immune Escape in Solid Tumors

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Renal Cell Carcinoma Induces Prostaglandin E2 and T-Helper Type 2 Cytokine Production in Peripheral Blood Mononuclear Cells

Abstract: Human RCC inhibits the host antitumor immune response by promoting PGE(2) production and Th2 cytokines in PBMC. Selective inhibition of COX-2 may have a role in abrogating this effect.

Cited by 41 publications

References 34 publications

Serum IL10 and circulating CD4+CD25high regulatory T cell numbers as predictors of clinical outcome and survival in patients with head and neck squamous cell carcinoma

Serum IL10 and circulating CD4+CD25high regulatory T cell numbers as predictors of clinical outcome and survival in patients with head and neck squamous cell carcinoma

Effect of soluble factors derived from oral cancer cells on the production of interferon-γ from peripheral blood mononuclear cells following stimulation with OK-432

Cancer Immunoediting: Elimination, Equilibrium, and Immune Escape in Solid Tumors

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Serum IL10 and circulating CD4⁺CD25^high regulatory T cell numbers as predictors of clinical outcome and survival in patients with head and neck squamous cell carcinoma

Serum IL10 and circulating CD4⁺CD25^high regulatory T cell numbers as predictors of clinical outcome and survival in patients with head and neck squamous cell carcinoma