Renal cell carcinoma in functional renal graft: Toward ablative treatments

Tillou, X.; Guleryuz, K.; Collon, Sylvie; Doerfler, A.

doi:10.1016/j.trre.2015.07.001

Cited by 36 publications

(45 citation statements)

References 72 publications

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“…An increase in the detection of mostly incidental tumors in renal transplants is associated with the increasing use of transplants from elderly donors and long-term immunosuppression [6]. Moreover, monitoring alone (regular ultrasound screening) can enhance the number of incidental tumors detected [6,7]. The mean time to diagnosis of the tumor after transplantation is 10 years, although, in our case, it took 16 years [7].…”

Section: Introductionmentioning

confidence: 68%

Inksto transplantato de novo karcinomos gydymas perkutanine radiodažnine abliacija: klinikinis atvejis

Paškonis¹,

Andreika²,

Andreika³

et al. 2015

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Pastebėta, jog piktybinių navikų dažnis žmonėms, kuriems persodinti inkstai, yra didesnis nei bendrojoje populiacijoje. Inkstų karcinomos sudaro 4,8 % visų navikų, nustatomų recipientams, ir vos 10 % – transplantate. Transplantato navikai gali būti perduoti donoro, metastazės iš kitų recipiento organų arba de novo (naujai) vystytis po transplantacijos. De novo navikai transplantate nustatomi vidutiniškai 10 metų po transplantacijos. Mes aprašome klinikinį atvejį 45 metų vyro, kuriam 16 metų po inksto persodinimo atsitiktinai aptikta besimptomė neišplitusi 15 mm dydžio papilinė inksto karcinoma apatiniame transplantato poliuje. Ligoniui sėkmingai atlikta minimaliai invazyvi procedūra – perkutaninė radiodažninė abliacija, kuri visiškai sunaikino naviką išsaugodama transplantato funkciją. Ankstyvųjų komplikacijų nenustatyta. Praėjus vieneriems metams po procedūros vėžinės ligos atsinaujinimo ar vėlyvųjų komplikacijų požymių nėra, išlieka adekvati transplantato funkcija be hemodializės poreikio.

show abstract

Section: Introductionmentioning

confidence: 68%

Inksto transplantato de novo karcinomos gydymas perkutanine radiodažnine abliacija: klinikinis atvejis

Paškonis¹,

Andreika²,

Andreika³

et al. 2015

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“…Generally, they have less aggressive nature in transplanted patients, independently of their location, except for the papillary tumor RCC, in which an increased aggressiveness is reported. Papillary renal cell carcinoma represents 5-15% of overall kidney neoplasm [22,23]. Moreover, papillary tumours are more frequent in the transplanted population than in the general population and are usually associated with acquired renal cystic disease (ARCD) of the native kidneys rather that allograft [20].…”

Section: Renal Cell Carcinoma Of the Grafted Kidneymentioning

confidence: 99%

“…Percutaneous radiofrequency or cryoablation therapy is wellestablished treatment for small and exophytic lesions since it is less invasive and has a low mortality rate besides it avoids renal ischemia associated with vascular clamping which is occasionally necessary [23]. Minimization or withdrawal of Calcineurin inhibitors and replace it with mTOR inhibitor (Sirolimus or Everolimus) is recommended [23].…”

Section: Treatmentmentioning

confidence: 99%

“…Minimization or withdrawal of Calcineurin inhibitors and replace it with mTOR inhibitor (Sirolimus or Everolimus) is recommended [23]. However, some authors prefer to maintain similar immunosuppressive schemes without modifications, as this will lead to decrease in the rejection risk and hence no clear correlation between immunosuppression and tumours in some reported literatures [26].…”

Section: Treatmentmentioning

confidence: 99%

“…Immunologic human leukocyte antigen typing and (DNA) genetic analysis should be done on each tumor specimen when possible, to detect the recipient or donor origin of the malignancy [3,4,23,[27][28][29].…”

Section: Conclusion and Recommendationsmentioning

confidence: 99%

See 2 more Smart Citations

Case Report: Renal Cell Carcinoma of First Kidney Allograft in Transplanted Recipient for Second Time

Alnour¹,

Alalawi²,

Khalifa³

et al. 2016

UNOAJ

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The uses of immunosuppressive therapy to preserve the new allograft function can significantly increases the incidence of malignancies in transplanted recipients compared with that of general population. The ability to identify and prevent solid organ tumours in the transplant patients, particularly early stages carcinomas depends on regular screening examinations and strict adherence to prophylactic measures. Screening of the patient and donor prior to transplant can help to detect any underlying pre-existing malignancy. Identification of tumor in renal allograft are usually accidental following ultrasonography, CT scan or MRI imaging, so special attention is essential during any imaging examination of renal allograft to detect an early probable tumours.We hereby, present a case record of 51 years old male who had his first kidney transplant in 1987 on the right side from living unrelated donor; he had approached ESRD in 2006 and underwent his second renal transplantation in June 2006 on the left side from living unrelated donor. Though he had stable kidney function, he started to have intermittent haematuria with lump at right lower loin. Allograft sonography had revealed a big mass in the first right transplanted kidney. CT scan with contrast demonstrated a large lobulated enhancing mass arising from the iliac fossa of first transplanted kidney with local, right common iliac vein metastasis and lungs metastasis. Due to above finding patient underwent right allograft nephrectomy.

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Microwave Ablation of Renal Cell Carcinoma of the Transplanted Kidney: Two Cases

Favi

Raiteri

Paone

et al. 2019

Cardiovasc Intervent Radiol

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Renal cell carcinoma in functional renal graft: Toward ablative treatments

Cited by 36 publications

References 72 publications

Inksto transplantato de novo karcinomos gydymas perkutanine radiodažnine abliacija: klinikinis atvejis

Inksto transplantato de novo karcinomos gydymas perkutanine radiodažnine abliacija: klinikinis atvejis

Case Report: Renal Cell Carcinoma of First Kidney Allograft in Transplanted Recipient for Second Time

Microwave Ablation of Renal Cell Carcinoma of the Transplanted Kidney: Two Cases

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