Renal Cell Carcinoma Fuhrman Grade and Histological Subtype Correlate With Complete Polymorphic Deletion of Glutathione S-Transferase M1 Gene

Martino, Michela de; Klatte, Tobias; Schatzl, Georg; Remzi, Mesut; Waldert, Matthias; Haitel, Andrea; Stancik, Igor; Kramer, Gero; Marberger, Michael

doi:10.1016/j.juro.2009.11.032

Cited by 23 publications

(18 citation statements)

References 21 publications

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“…These results are similar to the association found between GSTM1-null genotype and tumor grade in patients with renal cell carcinoma. 29 Our findings further imply the important role of GSTM1 and GSTA1 gene variants in protection from DNA damage, based on the highest levels of 8-OHdG in G3 TCC patients. What is more, at the molecular level this explains the influence of GST genotype on the prognosis of TCC patients.…”

Section: Commentsupporting

confidence: 71%

GSTM1-null and GSTA1-low activity genotypes are associated with enhanced oxidative damage in bladder cancer

et al. 2013

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Section: Commentsupporting

confidence: 71%

GSTM1-null and GSTA1-low activity genotypes are associated with enhanced oxidative damage in bladder cancer

et al. 2013

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“…Furthermore, some data extracted from the included studies were controversial; the details are provided below. The number of GSTM1 null genotypes in the case and control groups extracted from the study by Longuemaux [28] and the number of GSTM1 null genotypes in the control group extracted from the study by Martino [24] were controversial. Similarly, the data of the GSTT1 genotype present in the control group extracted from the study by Karami [25] and those of the GSTT1 null genotype in the case group extracted from the study by Martino were controversial [28].…”

Section: Discussionmentioning

confidence: 99%

“…The number of GSTM1 null genotypes in the case and control groups extracted from the study by Longuemaux [28] and the number of GSTM1 null genotypes in the control group extracted from the study by Martino [24] were controversial. Similarly, the data of the GSTT1 genotype present in the control group extracted from the study by Karami [25] and those of the GSTT1 null genotype in the case group extracted from the study by Martino were controversial [28]. Therefore, to derive a more precise estimation of the relationship between the GSTs genotype (GSTM1, GSTT1 and GSTP1) polymorphisms and RCC risk, we performed this meta-analysis and included a larger number of studies.…”

Section: Discussionmentioning

confidence: 99%

Glutathione S-Transferase Polymorphisms (GSTM1, GSTT1 and GSTP1) and Their Susceptibility to Renal Cell Carcinoma: An Evidence-Based Meta-Analysis

et al. 2013

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BackgroundThe association of the three Glutathione S-transferases (GSTs) polymorphisms (GSTM1, GSTT1 and GSTP1) genotypes with their individual susceptibilities to renal cell carcinoma (RCC) has not been well established. We performed a quantitative meta-analysis to assess the possible associations between the GSTM1, GSTT1 and GSTP1 genotypes and their individual susceptibilities to renal cell carcinoma.MethodsWe systematically searched the PubMed, CNKI and Embase databases to identify the relevant studies. Finally, 11 eligible studies were selected. The pooled odds ratios (ORs) with their 95% confidence intervals (CIs) were used to assess the association between the GSTs polymorphisms and the risk of RCC. Multiple subgroup analyses and quality assessment of the included studies were performed based on the available information.ResultsNone of the GSTs polymorphisms had a significant association with the RCC risk. Similar results were found in the subgroup analyses, except for the GSTs polymorphisms in the situations described below. The GSTM1 and GSTT1 active genotypes in subjects exposed to pesticides (GSTM1: OR = 3.44; 95% CI, 2.04–5.80; GSTT1: OR = 2.84; 95% CI, 1.75–4.60), most of the GSTs genotypes in Asian populations (GSTT1: OR = 2.39, 95% CI = 1.63–3.51; GSTP1: Dominant model: OR = 1.50, 95% CI = 1.14–1.99; Additive model: OR = 1.39, 95% CI = 1.12–1.73; AG vs. AA: OR = 1.47, 95% CI = 1.10–1.97; GG vs. AA: OR = 1.82, 95% CI = 1.07–3.09) and the dual null genotype of GSTT1-GSTP1 (OR = 2.84, 95% CI = 1.75–4.60) showed positive associations with the RCC risk.ConclusionOur present study provides evidence that the GSTM1, GSTT1 and GSTP1 polymorphisms are not associated with the development of RCC. However, more case-control studies are needed for further confirmation.

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“…According to the exclusion criteria, seven publications were excluded for lack of available data. Finally, 8 case-control studies with 4,460 subjects were included into this meta-analysis (Bruning et al, 1997;Longuemaux et al, 1999;Sweeney et al, 2000;Buzio et al, 2003;Moore et al, 2007;De Martino et al, 2010;Salinas-Sanchez et al, 2011;Ahmad et al, 2012). All included studies were English language literature.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

No Association Between the GSTM1 Null Genotype and Risk of Renal Cell Carcinoma: A Meta-analysis

Wang²,

Liu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: Many studies have focused on possible associations between the glutathione S-transferase M 1 (GSTM1) null genotype and risk of renal cell carcinoma (RCC), but the impact remains unclear owing to obvious inconsistencies among the findings. The present study aimed to quantify the strength of any association in a meta-analysis. Methods: We searched the PubMed, Embase and CBM databases for studies concerning the association between the GSTM1 null genotype and risk of RCC. We estimated the summary odds ratio (OR) with its 95% confidence intervals (95% CI) to assess the association. Results: The meta-analysis showed the GSTM1 null genotype was not associated with risk of RCC overall (OR = 1.04, 95% CI 0.92-1.18, P = 0.501). For Caucasians, the GSTM1 null genotype was also not associated with risk of RCC (OR=1.02, 95% CI 0.90-1.16, P = 0.761). The cumulative meta-analyses showed a trend of no obvious association between GSTM1 null genotype and risk of RCC as information accumulated. Sensitivity analyses by omitting those studies also did not materially alter the overall combined ORs. No evidence of publication bias was observed. Conclusion: Metaanalyses of available data show that the GSTM1 null genotype is not significantly associated with risk of renal cell carcinoma.

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Renal Cell Carcinoma Fuhrman Grade and Histological Subtype Correlate With Complete Polymorphic Deletion of Glutathione S-Transferase M1 Gene

Cited by 23 publications

References 21 publications

GSTM1-null and GSTA1-low activity genotypes are associated with enhanced oxidative damage in bladder cancer

GSTM1-null and GSTA1-low activity genotypes are associated with enhanced oxidative damage in bladder cancer

Glutathione S-Transferase Polymorphisms (GSTM1, GSTT1 and GSTP1) and Their Susceptibility to Renal Cell Carcinoma: An Evidence-Based Meta-Analysis

No Association Between the GSTM1 Null Genotype and Risk of Renal Cell Carcinoma: A Meta-analysis

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