Renal cell carcinoma: Current status and future prospects

Drucker, Beverly J.

doi:10.1016/j.ctrv.2005.07.009

Cited by 117 publications

(84 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1 This patient had a DFI of 8 months (another single lung metastasis, which had been resected), but the metastasis investigated herein was diagnosed 11 months after nephrectomy.-2 This patient received chemotherapy before metastasectomy. However, exclusion of this patient's tissue sample did not actually alter the results.…”

Section: Identification Of Metastasis-associated Genes By Meta-analysismentioning

confidence: 99%

“…3 The preferential localization of RCC Mets is the lung. 1 In contrast to the emerging development of molecular-based therapies for RCC in the last few years, 3 molecular prognostic markers are still missing. Despite the knowledge of several molecular factors involved in metastatic spread like angiogenesis, cell adhesion, invasion or migration, 4,5 little is known about specific characteristics of this complex process.…”

mentioning

confidence: 99%

“…The median survival of renal cell carcinoma (RCC) patients amounts to merely 6 to 12 months after Mets have been diagnosed. 1 RCC is the urological cancer with the highest percentage of tumour-related deaths 2 because metastasis occurs in about 60% of the patients. 3 The preferential localization of RCC Mets is the lung.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Gene signatures of pulmonary metastases of renal cell carcinoma reflect the disease‐free interval and the number of metastases per patient

Wuttig

Baier²,

Fuessel

et al. 2009

Intl Journal of Cancer

View full text Add to dashboard Cite

Our understanding of metastatic spread is limited and molecular mechanisms causing particular characteristics of metastasis are largely unknown. Herein, transcriptome-wide expression profiles of a unique cohort of 20 laser-resected pulmonary metastases (Mets) of 18 patients with clear-cell renal cell carcinoma (RCC) were analyzed to identify expression patterns associated with two important prognostic factors in RCC: the disease-free interval (DFI) after nephrectomy and the number of Mets per patient. Differentially expressed genes were identified by comparing early (DFI 9 months) and late (DFI 5 years) Mets, and Mets derived from patients with few ( 8) and multiple ( 16) Mets. Early and late Mets could be separated by the expression of genes involved in metastasis-associated processes, such as angiogenesis, cell migration and adhesion (e.g., PECAM1, KDR). Samples from patients with multiple Mets showed an elevated expression of genes associated with cell division and cell cycle (e.g., PBK, BIRC5, PTTG1) which indicates that a high number of Mets might result from an increased growth potential. Minimal sets of genes for the prediction of the DFI and the number of Mets per patient were identified. Microarray results were confirmed by quantitative PCR by including nine further pulmonary Mets of RCC. In summary, we showed that subgroups of Mets are distinguishable based on their expression profiles, which reflect the DFI and the number of Mets of a patient. To what extent the identified molecular factors contribute to the development of these characteristics of metastatic spread needs to be analyzed in further studies. ' UICC Key words: kidney cancer; lung metastases; oligonucleotide microarraysIn numerous tumour types, the development of metastases (Mets) causes the patients' death. The median survival of renal cell carcinoma (RCC) patients amounts to merely 6 to 12 months after Mets have been diagnosed. 1 RCC is the urological cancer with the highest percentage of tumour-related deaths 2 because metastasis occurs in about 60% of the patients. 3 The preferential localization of RCC Mets is the lung. 1 In contrast to the emerging development of molecular-based therapies for RCC in the last few years, 3 molecular prognostic markers are still missing. Despite the knowledge of several molecular factors involved in metastatic spread like angiogenesis, cell adhesion, invasion or migration, 4,5 little is known about specific characteristics of this complex process. These are, for example, primary-dependent site-specific metastasis, 6 varying dormancy periods of Mets originating from the same primary tumour entity causing disease-free intervals (DFI) ranging from several months to many years, or the differing number of Mets in patients with the same primary tumour. Knowing the molecular fundamentals of these phenomena would support the prognosis of patients' outcome and facilitate the decision for an appropriate therapy regime, particularly in RCC where the DFI and the number of Mets are important predictors of clinical...

show abstract

Section: Identification Of Metastasis-associated Genes By Meta-analysismentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Gene signatures of pulmonary metastases of renal cell carcinoma reflect the disease‐free interval and the number of metastases per patient

Wuttig

Baier²,

Fuessel

et al. 2009

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Dor óssea pode estar presente nos casos de metástase para o esqueleto e sintomas respiratórios nos casos de acometimento pulmonar (POMPEO, 2007). Varicocele de aparecimento agudo pode significar envolvimento de veia renal ou cava inferior (DRUCKER, 2005;POMPEO, 2007).…”

Section: Caracterização Do Carcinoma De Células Renaisunclassified

“…Apesar de tumores > 7,0 cm ainda poderem estar confinados ao rim, essa divisão dá um sentido de progressão da lesão, já que aumento no tamanho do tumor está associado a maior frequência de metástases BOSTWICK, 2008). Em nosso estudo, pacientes sintomáticos estavam associados a tumores > 4,0 cm e apresentavam maior média do tamanho tumoral em relação aos assintomáticos (7,46 cm x 3,95 cm DAVOODI et al, 1999;ODA et al, 2002;LJUNGBERG et al, 2003;DRUCKER, 2005;CORGNA;BETTI et al, 2007). Talvez (DONNELLAN e CHETTY, 1998).…”

unclassified