Renal cell cancer risk and occupational exposure to trichloroethylene: Results of a consecutive case‐control study in Arnsberg, Germany

Brüning, Thomas; Pesch, Beate; Wiesenhütter, B.; Rabstein, Sylvia; Lammert, Marga; Baumüller, A; Bolt, Hermann M.

doi:10.1002/ajim.10185

Cited by 96 publications

(72 citation statements)

References 33 publications

(61 reference statements)

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“…All three of these studies reported strikingly elevated relative risks for renal cell cancer associated with TCE exposure. [167][168][169] The fi ndings contrast starkly with results from other investigations, and several serious methodological shortcomings of these studies have been noted, [170][171][172] limiting any conclusion that can be drawn. To date, seven occupational cohort studies have evaluated the relationship between TCE exposure and specifi c types of cancer.…”

Section: Occupationcontrasting

confidence: 88%

Epidemiologic characteristics and risk factors for renal cell cancer

McLaughlin¹

2009

CLEP

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Abstract:Incidence rates of renal cell cancer, which accounts for 85% of kidney cancers, have been rising in the United States and in most European countries for several decades. Family history is associated with a two-to four-fold increase in risk, but the major forms of inherited predisposition together account for less than 4% of renal cell cancers. Cigarette smoking, obesity, and hypertension are the most consistently established risk factors. Analgesics have not been convincingly linked with renal cell cancer risk. A reduced risk of renal cell cancer among statin users has been hypothesized but has not been adequately studied. A possible protective effect of fruit and vegetable consumption is the only moderately consistently reported dietary fi nding, and, with the exception of a positive association with parity, evidence for a role of hormonal or reproductive factors in the etiology of renal cell cancer in humans is limited. A recent hypothesis that moderate levels of alcohol consumption may be protective for renal cell cancer is not strongly supported by epidemiologic results, which are inconsistent with respect to the categories of alcohol consumption and the amount of alcohol intake reportedly associated with decreased risk. For occupational factors, the weight of the evidence does not provide consistent support for the hypotheses that renal cell cancer may be caused by asbestos, gasoline, or trichloroethylene exposure. The established determinants of renal cell cancer, cigarette smoking, obesity, and hypertension, account for less than half of these cancers. Novel epidemiologic approaches, including evaluation of gene-environment interactions and epigenetic mechanisms of inherited and acquired increased risk, are needed to explain the increasing incidence of renal cell cancer. Keywords: renal cell cancer, epidemiology, risk factor, review Descriptive epidemiologyKidney cancer is the ninth most common cancer in developed countries.1 Approximately 85% of kidney cancers are renal parenchyma (renal cell) cancers, while the remainder for the most part are urothelial cancers of the renal pelvis.2 Approximately 80% of renal cell cancers are clear cell adenocarcinomas, the remainder being papillary (∼15%), chromophobe (∼5%), and collecting duct carcinomas (Ͻ1%). Both renal cell and renal pelvis cancers are about twice as common among men as among women, [1][2][3] with the mean age at diagnosis in the early 60s for renal cell cancer and in the late 60s for renal pelvis cancer. For renal pelvis cancer, there is a strong tendency to develop multiple transitional epithelial tumors, particularly in the urinary bladder and ureter. 4 For the most part, renal pelvis cancer parallels bladder cancer in epidemiologic characteristics and risk factors and has been addressed by the authors elsewhere.

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Section: Occupationcontrasting

confidence: 88%

Epidemiologic characteristics and risk factors for renal cell cancer

McLaughlin¹

2009

CLEP

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“…However, renal cell cancer cases displayed a somewhat higher proportion of the homozygous GSTP1 313A wild type (GSTP1*A), although this was not statistically signiWcant ( 2 test: P = 0.1071, when using only the original controls of Brüning et al (2003); P = 0.0781 with inclusion of the additional controls). Conclusion The re-investigation does not conWrm the working hypothesis of an inXuence of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 on renal cell cancer development due to high occupational exposures to trichloroethylene.…”

mentioning

confidence: 87%

Re-assessment of the influence of polymorphisms of phase-II metabolic enzymes on renal cell cancer risk of trichloroethylene-exposed workers

Wiesenhütter

Selinski

Golka

et al. 2007

Int Arch Occup Environ Health

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“…Exposure settings include occupational exposures in the aerospace and screw-cutting industries and exposure to the general population occurs through contaminated air, water, and soil. An increased risk of kidney cancer was reported in all of the studies in which there was a moderate to very high level of estimated TCE exposure (Henschler et al, 1995;Morgan et al, 1998;Vamvakas et al, 1998;Brüning et al, 2003;Raaschou-Nielsen et al, 2003;Zhao et al, 2005;Boice et al, 2006;Charbotel et al, 2006;Radican et al, 2008;Moore et al, 2010;Hansen et al, 2013), with most risk estimates being statistically significant. Additionally, positive exposureresponse relationships were reported in several case-control (Charbotel et al, 2006;Moore et al, 2010) and cohort studies (Zhao et al, 2005;Raaschou-Nielsen et al, 2003) using different exposure metrics.…”

Section: Cancermentioning

confidence: 96%

Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps

Cichocki

Guyton

Guha

et al. 2016

Journal of Pharmacology and Experimental Therapeutics

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Trichloroethylene (TCE) and perchloroethylene or tetrachloroethylene (PCE) are high-production volume chemicals with numerous industrial applications. As a consequence of their widespread use, these chemicals are ubiquitous environmental contaminants to which the general population is commonly exposed. It is widely assumed that TCE and PCE are toxicologically similar; both are simple olefins with three (TCE) or four (PCE) chlorines. Nonetheless, despite decades of research on the adverse health effects of TCE or PCE, few studies have directly compared these two toxicants. Although the metabolic pathways are qualitatively similar, quantitative differences in the flux and yield of metabolites exist. Recent human health assessments have uncovered some overlap in target organs that are affected by exposure to TCE or PCE, and divergent speciesand sex-specificity with regard to cancer and noncancer hazards. The objective of this minireview is to highlight key similarities, differences, and data gaps in target organ metabolism and mechanism of toxicity. The main anticipated outcome of this review is to encourage research to 1) directly compare the responses to TCE and PCE using more sensitive biochemical techniques and robust statistical comparisons; 2) more closely examine interindividual variability in the relationship between toxicokinetics and toxicodynamics for TCE and PCE; 3) elucidate the effect of coexposure to these two toxicants; and 4) explore new mechanisms for target organ toxicity associated with TCE and/or PCE exposure.

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Renal cell cancer risk and occupational exposure to trichloroethylene: Results of a consecutive case‐control study in Arnsberg, Germany

Abstract: The study supports the human nephrocarcinogenicity of trichloroethylene.

Cited by 96 publications

References 33 publications

Epidemiologic characteristics and risk factors for renal cell cancer

Epidemiologic characteristics and risk factors for renal cell cancer

Re-assessment of the influence of polymorphisms of phase-II metabolic enzymes on renal cell cancer risk of trichloroethylene-exposed workers

Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps

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