Renal Blood Flow in Acute Renal Failure Measured by Renal Arterial Infusion of Indocyanine Green

Walker, Josephine G.; Silva, H.; Lawson, Tanya; Ryder, Jill A.; Shaldon, Stanley

doi:10.3181/00379727-112-28214

Cited by 26 publications

(11 citation statements)

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“…The validity of creatinine clearance as a measure of glomerular filtration rate has recently been put in doubt (1) and it must be suspect in a condition where tubular damage is present, since in the human tubular secretion of creatinine normally occurs particularly at high serum levels. Secondly, the renal blood flow is now known (11,20) to be much greater during anuric and polyuric phases of acute renal fail ure than was believed by Bull, J oekes and Lowe (3).…”

Section: Discussionmentioning

confidence: 89%

Intravenous Urography in Experimental Acute Renal Failure in the Rat

Chamberlain¹,

Sherwood²

1967

Nephron

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Intravenous urography using large doses of diatrizoate has been carried out in rats suffering from acute renal failure states induced either by temporary renal ischaemia or by intraperitoneal injection of mercuric chloride. All the animals were azotaemic, all had some degree of histological tubular necrosis but urine output ranged from anuria to marked polyuria. A dense nephrogram was always obtained even in animals with complete anuria. It is concluded that considerable glomerular filtration probably occurs in acute renal failure whatever the urine output.

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Section: Discussionmentioning

confidence: 89%

Intravenous Urography in Experimental Acute Renal Failure in the Rat

Chamberlain¹,

Sherwood²

1967

Nephron

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“…These techniques can be used to investigate RBF in ARF even in complete anuria [34,35,40,43,56] . Thermodilution has also been used to measure RBF by use of a renal vein catheter.…”

Section: Techniques For the Measurement Of Rbfmentioning

confidence: 99%

Renal Blood Flow during Acute Renal Failure in Man

et al. 2009

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Background:In the critically ill, ischemia secondary to decreased renal blood flow (RBF) is believed to be central to the pathogenesis of acute renal failure (ARF); however, the scientific basis for this conclusion has not been systematically evaluated. Methods: Systematic interrogation of the Pubmed database, and screening bibliographies of retrieved reports, for studies of human ARF where RBF was measured. Results: Thirty-two articles published between 1944 and 2008 describing RBF in 373 patients with ARF were identified. Overall, mean RBF during ARF was 387 ml/min. It was 329 ml/min when estimated by clearance-based techniques (15 studies) and 471 ml/min when measured with nonclearance-based techniques (17 studies). Only 46 patients had measurements in the intensive care unit where mean RBF was 306 ml/min. Normal RBF was reported in 14 publications, mean 1,192 ml/min. Conclusions: Limited information is available on RBF during ARF in the critically ill. Measurements in contemporary patients are required to further our understanding of this condition.

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“…The measurement of renal blood flow by means of constant infusion or a single injection of an indicator dye was introduced by Shaldon 17, 18 Walker,19,20 and Reubi2' and their associates. The single injection dyedilution method has proved to be an accurate and convenient method for evaluation of renal hemodynamics.…”

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confidence: 99%

Unilateral Renal Hemodynamics and Characteristics of Dye-Dilution Curves in Patients with Essential Hypertension and Renal Disease

et al. 1967

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SUMMARYTo gain information concerning cardiorenal hemodynamics in essential hypertension, renal vascular disease, and chronic glomerulonephritis, indocyanine green was used to determine renal blood flow (RBF), renal blood volume (RBV), mean transit time (MTT), appearance time (AT), buildup time (BT), and passage time (PT), in 83 kidneys of 47 hypertensive patients and eight volunteers. Cardiac output (CO) was concurrently measured. Dye, injected into the renal artery, while renal venous blood was drawn through a cuvette densitometer, gave a reproducible curve within 7.7% + 2% with multi-exponential washout. RBF (dye) agreed closely (dye/PAH ratio = 1.04) with para-aminohippurate (PAH) estimated renal blood flow in 18 kidneys. The RBF and RBV were significantly higher in patients with essential hypertension with high cardiac output than in those with normal cardiac output and were reduced significantly in patients with renal vascular diseases, although CO was the same. The contour of dye curves differed between the various diseases due to significant differences in BT and PT. AT and BT were significantly prolonged in patients with malignant hypertension, renal artery stenosis, and chronic glomerulonephritis. BT was significantly shorter in essential hypertensives than in nonnals. PT and MTT were significantly longer in malignant hypertensive, renal artery stenosis, and chronic glomerulonephritis groups. Passage time was significantly longer in glomerulonephritics than in nephrosclerotics. The procedure has value for the study of human renal circulation.

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Renal Blood Flow in Acute Renal Failure Measured by Renal Arterial Infusion of Indocyanine Green

Cited by 26 publications

References 0 publications

Intravenous Urography in Experimental Acute Renal Failure in the Rat

Intravenous Urography in Experimental Acute Renal Failure in the Rat

Renal Blood Flow during Acute Renal Failure in Man

Unilateral Renal Hemodynamics and Characteristics of Dye-Dilution Curves in Patients with Essential Hypertension and Renal Disease

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