Renal biopsy: Still a landmark for the nephrologist

Visconti, Luca; Cernaro, Valeria; Ricciardi, Carlo Alberto; Lacava, Viviana; Pellicanò, Vincenzo; Lacquaniti, Antonio; Buemi, Michele; Santoro, Domenico

doi:10.5527/wjn.v5.i4.321

Cited by 43 publications

(43 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Renal biopsy is an invasive but safe procedure that is required for the diagnosis and management of various clinical spectrum of renal diseases in children. 9 Renal biopsy in children is done with extreme caution after adequate preparation and all precautions are taken to obtain good tissue samples with minimal risk of complications and discomfort to the child. Failure rate of 5.3% was observed in this study as compared to 2.3 to 11.8% in other studies.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Histopathological audit of renal biopsy in Nepalese children: two center experience

Shrestha

Dhakal

Basnet³

et al. 2018

J Pathol Nep

View full text Add to dashboard Cite

Background: Renal biopsy is an invaluable tool which provides histopathological description of renal disease in terms of severity of lesion and helps in formulating the long term plan. However such studies with histopathological description of renal biopsy among Nepalese children are scarce.Material and Methods: This was a retrospective study conducted among all children aged less than 18 years who underwent renal biopsy at two tertiary centers in Nepal between July 2015 and December 2017.Results: All 72 renal biopsies were done with Bard 18G spring loaded gun. Nephrotic syndrome and mixed nephritic-nephrotic features were the commonest indications for renal biopsy. IgA nephropathy was the most frequent histopathological diagnosis (20.8%) which was mainly observed in children of age group 11-18 years followed by minimal change disease (16.7%) and diffuse proliferative glomerulonephritis (16.7%). Majority of children with recurrent gross hematuria (6/7) or mixed nephritic-nephrotic features (6/8) had IgA nephropathy. Focal segmental glomerulosclerosis (6/8) was commonest in children with steroid resistant nephrotic syndrome and nephrotic syndrome with atypical features. Majority of children (10/12) with diffuse proliferative glomerulonephritis had features of poststreptococcal glomerulonephritis and 6/12 had crescents in glomeruli. Lupus nephritis (13.9%) was the commonest secondary cause of glomerular pathology and was observed predominantly in 11-18 years age.Conclusion: Renal biopsy is safe and not associated with clinically significant complications. Nephrotic syndrome was the commonest indication for renal biopsy and minimal change disease predominated. IgA nephropathy was the commonest histological diagnosis overall, as well as in children who presented with recurrent gross hematuria or mixed nephritic-nephrotic features.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Biopsy reports which included ≥10 glomeruli were considered adequate for the study. 9 Data analysis was done with SPSS17.0 and percentages and proportions of indications, histopathological diagnosis, demographic parameters and complications were calculated.…”

Section: Methodsmentioning

confidence: 99%

Histopathological audit of renal biopsy in Nepalese children: two center experience

Shrestha

Dhakal

Basnet³

et al. 2018

J Pathol Nep

View full text Add to dashboard Cite

show abstract

“…Commonly, the clinical course is asymptomatic, with a gradual creatinine increment, and most patients improve with the use of low dose of corticosteroids. As an added complexity, our patient had a single kidney due to prior nephrectomy and, therefore, kidney biopsy was discarded then of evaluating the risks and benefits (18). Preliminary clinical data seem to show that systemic corticosteroids and other immunosuppressant drugs used for immune-related adverse events might not have such a negative impact on efficacy.…”

Section: Background and Discussionmentioning

confidence: 99%

Long-term Response to Nivolumab and Acute Renal Failure in a Patient with Metastatic Papillary Renal Cell Carcinoma and a PD-L1 Tumor Expression Increased with Sunitinib Therapy: A Case Report

et al. 2016

View full text Add to dashboard Cite

IntroductionPapillary renal cell carcinoma (PRCC), which represents around 20% of renal cell carcinomas, is a heterogeneous disease that includes different tumor types with several clinical and molecular phenotypes. Nivolumab, a fully human IgG4 programed cell death protein 1 immune checkpoint inhibitor antibody, has shown not only an overall survival advantage when compared to everolimus but also a relatively good side-effect profile among patients with previously treated advanced or metastatic renal cell carcinoma.Case reportWe describe a case of a young man diagnosed with PRCC that achieved a durable response to nivolumab despite a temporary suspension of the treatment due to a renal function side effect. To the best of our knowledge, it is the first renal failure secondary to nivolumab in a metastatic renal cell carcinoma patient.Concluding remarksNivolumab is a promising drug in patients with metastatic PRCC and long-term responses can be achieved. In case of acute renal failure secondary to this treatment, temporary therapy suspension and a low dose of systemic corticosteroids can recover renal function without a negative impact on treatment efficacy.

show abstract

“…I will now present the rationale for renal biopsy to establish renal diagnoses [1]. The classification which follows is the opinion of the author and editor based on over 45 years of experience and exposure to the pioneers in use of renal biopsy for diagnosis [2][3][4]. My goal is to simplify this argument for performing this invasive procedure to clarify the confusing array of renal diseases with indistinct or asymptomatic presentations.…”

Section: Introductionmentioning

confidence: 99%

Introductory Chapter: Renal Diseases

Zawada¹

2020

Renal Diseases

View full text Add to dashboard Cite

Renal biopsy: Still a landmark for the nephrologist

Abstract: Renal biopsy was performed for the first time more than one century ago, but its clinical use was routinely introduced in the 1950s.

Cited by 43 publications

References 59 publications

Histopathological audit of renal biopsy in Nepalese children: two center experience

Histopathological audit of renal biopsy in Nepalese children: two center experience

Long-term Response to Nivolumab and Acute Renal Failure in a Patient with Metastatic Papillary Renal Cell Carcinoma and a PD-L1 Tumor Expression Increased with Sunitinib Therapy: A Case Report

Introductory Chapter: Renal Diseases

Contact Info

Product

Resources

About