Renal Biopsy in Children—Effect on Treatment Decisions: A Single-Center Experience

Pilania, Rakesh Kumar; Venkatesh, Vybhav; Nada, Ritambhra; Vignesh, Pandiarajan; Jindal, Ankur Kumar; Suri, Deepti; Tiewsoh, Karalanglin

doi:10.1007/s12098-021-03721-9

Cited by 12 publications

(12 citation statements)

References 9 publications

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“…There were no differences in sex distribution, likely due to similar prevalence of MCD among sexes 9,12,13 . This is consistent with most studies, although a study in Serbia found a higher prevalence of females among patients submitted to pediatric percutaneous KB 8 and some studies report a slight prevalence in males 9,14 .…”

Section: Discussionsupporting

confidence: 90%

“…Sex distribution was similar over the three time periods. Median age at time of biopsy was 11 (7)(8)(9)(10)(11)(12)(13)(14), with no significant difference among time periods.…”

Section: Resultsmentioning

confidence: 98%

“…Resultados: Constatamos que foram realizadas 228 BR, 78 (34,2%) no período 1, 91 (39,9%) no período 2, 59 (25,9%) no período 3. A idade mediana na BR foi 11 (7)(8)(9)(10)(11)(12)(13)(14) anos. As principais indicações para BR foram síndrome nefrótica (SN) (42,9%), hematúria e/ou proteinúria não nefrótica (35,5%), lesão renal aguda (13,2%).…”

Section: Percutaneous Kidney Biopsies In Children: a 24-year Review I...unclassified

“…Results: We found that 228 KB were performed, 78 (34.2%) in period 1, 91 (39.9%) in period 2, and 59 (25.9%) in period 3. The median age at KB was 11 (7)(8)(9)(10)(11)(12)(13)(14) years. The main indications for KB were nephrotic syndrome (NS) (42.9%), hematuria and/ or non-nephrotic proteinuria (35.5%), and acute kidney injury (13.2%).…”

Section: Introductionmentioning

confidence: 99%

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Percutaneous kidney biopsies in children: a 24-year review in a tertiary center in northern Portugal

Sousa,

Brás,

Menezes

et al. 2024

Braz. J. Nephrol.

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Introduction: Percutaneous kidney biopsy (KB) is crucial to the diagnosis and management of several renal pathologies. National data on native KB in pediatric patients are scarce. We aimed to review the demographic and clinical characteristics and histopathological patterns in children who underwent native percutaneous KB over 24 years. Methods: Retrospective observational study of patients undergoing native percutaneous KB in a pediatric nephrology unit between 1998 and 2021, comparing 3 periods: period 1 (1998–2005), period 2 (2006–2013), and period 3 (2014–2021). Results: We found that 228 KB were performed, 78 (34.2%) in period 1, 91 (39.9%) in period 2, and 59 (25.9%) in period 3. The median age at KB was 11 (7–14) years. The main indications for KB were nephrotic syndrome (NS) (42.9%), hematuria and/or non-nephrotic proteinuria (35.5%), and acute kidney injury (13.2%). Primary glomerulopathies were more frequent (67.1%), particularly minimal change disease (MCD) (25.4%), IgA nephropathy (12.7%), and mesangioproliferative glomerulonephritis (GN) (8.8%). Of the secondary glomerulopathies, lupus nephritis (LN) was the most prevalent (11.8%). In group 1, hematuria and/or non-nephrotic proteinuria were the main reasons for KB, as opposed to NS in groups 2 and 3 (p < 0.01). LN showed an increasing trend (period 1–3: 2.6%–5.3%) and focal segmental glomerular sclerosis (FSGS) showed a slight decreasing trend (period 1–3: 3.1%–1.8%), without statistical significance. Conclusions: The main indication for KB was NS, which increased over time, justifying the finding of MCD as main histological diagnosis. LN showed an increase in incidence over time, while FSGS cases did not increase.

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Section: Discussionsupporting

confidence: 90%

“…Sex distribution was similar over the three time periods. Median age at time of biopsy was 11 (7)(8)(9)(10)(11)(12)(13)(14), with no significant difference among time periods.…”

Section: Resultsmentioning

confidence: 98%

Section: Percutaneous Kidney Biopsies In Children: a 24-year Review I...unclassified

Section: Introductionmentioning

confidence: 99%

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Percutaneous kidney biopsies in children: a 24-year review in a tertiary center in northern Portugal

Sousa,

Brás,

Menezes

et al. 2024

Braz. J. Nephrol.

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“…The most common histopathological nding in SRNS is FSGS [19]. Ibrahim-Seif and Pilania reported FSGS and MCD as the most common histopathological ndings, respectively [21,22]. Conversely, the most common histopathological nding was MPGN in a retrospective study including 392 Turkish children with NS and it was stated that it might be due to unidenti ed causes such as infectious agents or environmental factors that can trigger MPGN [23].…”

Section: Discussionmentioning

confidence: 99%

Clinical Course of Idiopathic Nephrotic Syndrome in Children: predictors of steroid resistance

Yıldız

Çiçek

Güven

et al. 2022

Preprint

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Background: Nephrotic Syndrome (NS) is one of the most common renal diseases in children. Clinical response to corticosteroids is an important prognostic factor for long-term renal outcome. We aimed to evaluate the clinical parameters, histopathological findings and complications of NS patients and factors predicting steroid resistance in a single tertiary center. Methods: A hundred and sixty two children (57 girls, 105 boys) with NS followed between 1998 and 2018 in Department of Pediatric Nephrology were analyzed in a retrospective cohort. Secondary causes and infantile NS cases were excluded. Results: The median (IQR; range) age of the children at presentation and follow up time were 4.9(5.7; 0.1-16.8) and 5.5(5.4; 0.1-20.3) years, respectively. A hundred and thirty four (82.7%) patients were steroid-sensitive nephrotic syndrome (SSNS) and 28(17.3%) were steroid-resistant nephrotic syndrome (SRNS). Age at the first presentation was lower in SSNS group (p=0.002). Hypertension, macroscopic and microscopic hematuria were higher in SRNS group (p<0.001). Percutaneous kidney biopsy was performed in 56(34.6%) patients. The most common histopathological findings were focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD) and membranoproliferative glomerulonephritis (MPGN) respectively. Four patients with FSGS were subsequently diagnosed as Alport syndrome due to electron microscopic findings and genetic analysis. Four patients with FSGS and one with MPGN reached to end stage kidney disease.Conclusion:The late onset is still an important sign for SRNS. Microscopic and macroscopic hematuria and hypertension may also give a hint for potential steroid resistance. We emphasize that FSGS is a biopsy finding that may reveal to different diagnosis in SRNS.

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