Renal Biopsy Findings in Children Receiving Long-Term Treatment with Cyclosporine A Given as a Single Daily Dose

Benefits of Once-Daily Administration of Cyclosporine A for Children with Steroid-Dependent, Relapsing Nephrotic Syndrome

“…As a result, the long-term efficacy of CsA did not differ substantially between the two groups, although the observation period was relatively longer for TDD patients. Posttreatment renal biopsies also suggested the relative safety of CsA treatment administered in accordance with the SDD protocol (Tanaka et al 2006a). We think that the C 2 point blood level of CsA achieved with the SDD protocol accounted for an efficacy equal to that attained with the TDD protocol, while the low C 0 blood level of the drug probably accounted for its safety, although this remains speculative (Nakahata et al 2005;Takeda et al 2007).…”

Nephrotoxicity of once-daily cyclosporine A in minimal change nephrotic syndrome

“…However, little information is available in children with steroid-dependent MCNS regarding CsAN after long-term once-daily CsA therapy. Tanaka et al first described renal biopsy findings in five children with steroiddependent MCNS administered once-daily CsA therapy to maintain the peak blood level at around 800 ng/ml [14]. They reported that no lesions suggestive of CsAN were observed in any post-treatment renal biopsies.…”

Steroid-resistant idiopathic nephrotic syndrome in children: long-term follow-up and risk factors for end-stage renal disease

“…FRC ocorreu em 57 pacientes. A sobrevida renal foi de 71,5%, 58,4%, 55,3%, 35,6% e 28,5% aos 5, 10, 15, 20 e 25 anos, respectivamente. A análise univariada demonstrou que a idade maior ao início da doença, resistência inicial aos esteroides, hematúria, hipertensão, glomeruloesclerose segmentar e focal (GESF) e resistência aos imunossupressores foram fatores de risco para FRC.…”