Renal Artery Stenosis in Swine: Feasibility of MR Assessment of Renal Function during Percutaneous Transluminal Angioplasty

Park, Jonathan K.; Rhee, Thomas K.; Cashen, Ty A.; Shin, Wanyong; Schirf, Brian E.; Gehl, James A.; Larson, Andrew C.; Prasad, Pottumarthi V.; Li, Debiao; Carroll, Timothy J.; Omary, Reed A.

doi:10.1148/radiol.2433060184

Cited by 5 publications

(6 citation statements)

References 31 publications

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“…The deviation between the MR estimation of skGFR and 24 h creatinine clearance was 41.0%. Conclusion: The current study and prior reports along similar lines suggest that MR is a promising tool for the rapid, noninvasive and simultaneous assessment of both renal anatomy and function [1][2][3]. This …”

supporting

confidence: 73%

“…Methods: MRI experiments were performed on a small-bore 2 T magnet. Ventilation images were acquired on rats and mice using 3 He polarized at about 20% polarization level. Most ventilation imaging studies were performed using short echo time imaging sequences with radial or spiral sampling.…”

mentioning

confidence: 99%

“…Most ventilation imaging studies were performed using short echo time imaging sequences with radial or spiral sampling. For longitudinal studies, in order to ensure minimal interference with the physio-pathological state of the animal, 3 He imaging was performed during animal spontaneous breathing via a mask connected to an HP 3 He reservoir. This protocol was successfully applied for the longitudinal evaluation of lung exposure to nanoparticles and for the assessment of broncho-constriction effects.…”

mentioning

confidence: 99%

“…This protocol was successfully applied for the longitudinal evaluation of lung exposure to nanoparticles and for the assessment of broncho-constriction effects. Similarly, the feasibility of pO 2 and oxygen consumption imaging was successfully demonstrated in rat and mouse [2,3]. Results: The biodistribution and the clearance of iron-oxide nanoparticles inside the lungs could be monitored during a 2 week longitudinal study [ Fig.…”

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confidence: 99%

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CMR 2007: 12.01: Utilization of small molecular weight extracellular fluid markers, such as MR contrast media, to noninvasively acquire single kidney glomerular filtration rate: findings in human subjects with a solitary kidney

Katzberg

Buonocore

Low

et al. 2007

Contrast Media & Molecular

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confidence: 73%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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CMR 2007: 12.01: Utilization of small molecular weight extracellular fluid markers, such as MR contrast media, to noninvasively acquire single kidney glomerular filtration rate: findings in human subjects with a solitary kidney

Katzberg

Buonocore

Low

et al. 2007

Contrast Media & Molecular

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“…Angioplasty (widening of the blood vessel) work has been completed using magnetic resonance to guide the procedure and while the authors state that the work is preliminary, these authors believe that future hardware, and software advances will improve the performance of the procedures further (Omary et al, 2006;Park et al, 2007a and2007b).…”

Section: Renal Physiologymentioning

confidence: 99%

Porcine models for the metabolic syndrome, digestive and bone disorders: a general overview

Litten-Brown

Corson

Clarke

2010

Animal

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The aim of this review article is to provide an overview of the role of pigs as a biomedical model for humans. The usefulness and limitations of porcine models have been discussed in terms of metabolic, cardiovascular, digestive and bone diseases in humans. Domestic pigs and minipigs are the main categories of pigs used as biomedical models. One drawback of minipigs is that they are in short supply and expensive compared with domestic pigs, which in contrast cost more to house, feed and medicate. Different porcine breeds show different responses to the induction of specific diseases. For example, ossabaw minipigs provide a better model than Yucatan for the metabolic syndrome as they exhibit obesity, insulin resistance and hypertension, all of which are absent in the Yucatan. Similar metabolic/physiological differences exist between domestic breeds (e.g. Meishan v. Pietrain). The modern commercial (e.g. Large White) domestic pig has been the preferred model for developmental programming due to the 2-to 3-fold variation in body weight among littermates providing a natural form of foetal growth retardation not observed in ancient (e.g. Meishan) domestic breeds. Pigs have been increasingly used to study chronic ischaemia, therapeutic angiogenesis, hypertrophic cardiomyopathy and abdominal aortic aneurysm as their coronary anatomy and physiology are similar to humans. Type 1 and II diabetes can be induced in swine using dietary regimes and/or administration of streptozotocin. Pigs are a good and extensively used model for specific nutritional studies as their protein and lipid metabolism is comparable with humans, although pigs are not as sensitive to protein restriction as rodents. Neonatal and weanling pigs have been used to examine the pathophysiology and prevention/treatment of microbial-associated diseases and immune system disorders. A porcine model mimicking various degrees of prematurity in infants receiving total parenteral nutrition has been established to investigate gut development, amino acid metabolism and non-alcoholic fatty liver disease. Endoscopic therapeutic methods for upper gastrointestinal tract bleeding are being developed. Bone remodelling cycle in pigs is histologically more similar to humans than that of rats or mice, and is used to examine the relationship between menopause and osteoporosis. Work has also been conducted on dental implants in pigs to consider loading; however with caution as porcine bone remodels slightly faster than human bone. We conclude that pigs are a valuable translational model to bridge the gap between classical rodent models and humans in developing new therapies to aid human health.

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MR determination of glomerular filtration rate in subjects with solitary kidneys in comparison to clinical standards of renal function: feasibility and preliminary report

Katzberg

Buonocore

Low

et al. 2009

Contrast Media & Molecular

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This study was conducted to demonstrate the feasibility of quantifying single kidney glomerular filtration rate (skGFR) by magnetic resonance (MR) by comparison to the clinical estimates of GFR in volunteer subjects with a single kidney. Seven IRB-approved subjects with a solitary kidney, stable serum creatinine (SCr) and a 24 h creatinine clearance (CrCl) volunteered to undergo an MR examination that determined renal extraction fraction (EF) with a breathhold inversion recovery echo planar pulse sequence and renal blood flow with a velocity encoded phase imaging sequence. The product of EF and blood flow determines GFR. These values were compared with the 24 h CrCl, estimated GFR by the modification of diet in renal disease (MDRD) regression analysis and the Cockroft-Gault (CG) determination of CrCl. The mean and standard deviation of differences between the MR GFR, MDRD and CG vs the 24 h CrCl were 12.3+/-35.7, -8.9+/-18.5 and 1.2+/-19.6, respectively. The Student t-test showed that none of the mean differences were statistically significant between techniques. This clinical investigation shows that MR can be used for skGFR determination in human subjects with comparable values to those derived from clinically used serum-based GFR estimation techniques.

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Renal Artery Stenosis in Swine: Feasibility of MR Assessment of Renal Function during Percutaneous Transluminal Angioplasty

Abstract: In swine, MR imaging can reveal changes in renal function after x-ray-guided PTA for unilateral RAS.

Cited by 5 publications

References 31 publications

CMR 2007: 12.01: Utilization of small molecular weight extracellular fluid markers, such as MR contrast media, to noninvasively acquire single kidney glomerular filtration rate: findings in human subjects with a solitary kidney

CMR 2007: 12.01: Utilization of small molecular weight extracellular fluid markers, such as MR contrast media, to noninvasively acquire single kidney glomerular filtration rate: findings in human subjects with a solitary kidney

Porcine models for the metabolic syndrome, digestive and bone disorders: a general overview

MR determination of glomerular filtration rate in subjects with solitary kidneys in comparison to clinical standards of renal function: feasibility and preliminary report

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