Renal artery stenosis: grading of hemodynamic changes with cine phase-contrast MR blood flow measurements.

Schoenberg, Stefan O.; Knopp, Michael V.; Bock, Michael; Kallinowski, F.; Just, Armin; Essig, Marco; Hawighorst, H.; Schad, Lothar R.; Kaick, G. van

doi:10.1148/radiology.203.1.9122415

Cited by 131 publications

(63 citation statements)

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“…Most applications focus on the large thoracic vessels (13), the cardiac chambers (14), and the renal arteries (15). The results presented in these studies reflect the development of flow-sensitive MRI over the past 15 years in terms of pulse sequence development and analysis and visualization of blood flow.…”

mentioning

confidence: 56%

Visualization of iliac and proximal femoral artery hemodynamics using time‐resolved 3D phase contrast MRI at 3T

Frydrychowicz

Winterer

Zaitsev

et al. 2007

Magnetic Resonance Imaging

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Purpose:To demonstrate the feasibility of time-resolved 3D MR velocity mapping at 3 Tesla for the visualization of vascular hemodynamics in normal iliac and femoral arteries. Materials and Methods:Electrocardiographically (ECG) synchronized three-dimensional (3D) CINE phase-contrast MRI with three-directional flow encoding was adapted to analyze flow in peripheral arteries at 3T. Visualization of peripheral arterial hemodynamics within the acquired data volume included 3D streamlines and time-resolved 3D particle traces within the major vessels and localized analysis of flow profiles using 2D-vector graphs. Data was visually compared to results from color-coded duplex ultrasound (US).Results: Global and detailed local blood flow characteristics were successfully analyzed in all subjects. In agreement with US findings, normal laminar flow patterns without flow acceleration or disturbances were visualized in all healthy individuals. In an exemplary patient measurement multiple segmental flow accelerations could be demonstrated. MRI additionally revealed complex helical flow alterations distal to a moderate stenosis. Conclusion:Due to the full spatial and temporal coverage of the arteries of interest, 3D CINE phase contrast MRI at 3T is a promising tool for the evaluation of vascular hemodynamics in peripheral arteries. Future methodological improvements will be directed to improve spatial and temporal resolution as well as quantitative data analysis. Moreover, the technique will have to be evaluated in patients in comparison to standard diagnostic tools.

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mentioning

confidence: 56%

Visualization of iliac and proximal femoral artery hemodynamics using time‐resolved 3D phase contrast MRI at 3T

Frydrychowicz

Winterer

Zaitsev

et al. 2007

Magnetic Resonance Imaging

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“…For example, Schoenberg et al (8) showed that MR PC flow measurements and the shape of the flow waveform throughout the cardiac cycle could be used to identify the hemodynamic significance of vascular pathologies in the renal arteries. However, they concluded that a higher temporal resolution than that achievable with commercially available MR flow measurement methods was needed to provide a more accurate demonstration of the flow waveform.…”

mentioning

confidence: 99%

Cine flow measurements using phase contrast with undersampled projections: In vitro validation and preliminary results in vivo

Wentland

Korosec

Vigen

et al. 2006

Magnetic Resonance Imaging

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Purpose:To assess the accuracy of flow measurements in vitro and in vivo during scan times shorter than a breathhold using a 2D cine phase contrast (PC) undersampled radial acquisition method, which may be useful for measuring flow, especially in vessels subject to motion during respiration. Materials and Methods:For in vitro assessment, a flow phantom was imaged at various flow rates and undersampling factors. For in vivo assessment, five normal subjects were imaged and the flow rate in the aorta was compared with the sum of the flow rates in the iliac arteries. Results:For results in vitro, the accuracy of flow measurements was maintained with scan times as low as 13-17 seconds. For results in vivo, scans acquired in less than 25 seconds provided flow measurements in the aorta that corresponded well to the sum of flow measurements in the iliac arteries. Conclusion:The undersampled radial acquisition cine PC technique provided accurate flow measurements in a flow phantom and in healthy human volunteers in scan times shorter than a typical breath-hold.

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“…However, this technique does not allow assessment of the functional significance of the stenosis. MR phase-contrast blood flow measurements have been shown to accurately assess hemodynamic changes in the renal artery, but can not grade renal parenchyma damage (13,14).…”

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confidence: 99%

Quantification of renal perfusion abnormalities using an intravascular contrast agent (part 2): Results in animals and humans with renal artery stenosis

Schoenberg

Aumann

Just

et al. 2003

Magnetic Resonance in Med

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The interrelation between the morphologic degree of renal artery stenosis and changes in parenchymal perfusion is assessed using an intravascular contrast agent. In seven adult foxhounds, different degrees of renal artery stenosis were created with an inflatable clamp implanted around the renal artery. Dynamic susceptibility-weighted gradient-echo imaging was used to measure signal-time curves in the renal artery and the renal parenchyma during administration of 1.5 mg/kg BW of an intravascular ultrasmall particle iron oxide (USPIO) contrast agent. From the dynamic series, regional renal blood volume (rRBV), regional renal blood flow (rRBF), and mean transit time (MTT) were calculated. The morphologic degree of stenosis was measured in the steady state using a high-resolution 3D contrast-enhanced (CE) MR angiography (MRA) sequence (voxel size ‫؍‬ 0.7 ؋ 0.7 ؋ 1 mm 3 ). Five patients with renoparenchymal damage due to long-standing renal artery stenosis were evaluated. In the animal stenosis model, cortical perfusion remained unchanged for degrees of renal artery stenosis up to 80%. With degrees of stenoses > 80%, cortical perfusion dropped to 151 ؎ 54 ml/100 g of tissue per minute as compared to a baseline of 513 ؎ 76 ml/100 g/min. In the patients, a substantial difference in the cortical perfusion of more than

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Renal artery stenosis: grading of hemodynamic changes with cine phase-contrast MR blood flow measurements.

Abstract: Quantitative and qualitative analysis of cardiac-gated cine phase-contrast MR flow velocity curves provided a highly accurate method to detect hemodynamic abnormalities in patients with suspected renal artery stenosis.

Cited by 131 publications

References 0 publications

Visualization of iliac and proximal femoral artery hemodynamics using time‐resolved 3D phase contrast MRI at 3T

Visualization of iliac and proximal femoral artery hemodynamics using time‐resolved 3D phase contrast MRI at 3T

Cine flow measurements using phase contrast with undersampled projections: In vitro validation and preliminary results in vivo

Quantification of renal perfusion abnormalities using an intravascular contrast agent (part 2): Results in animals and humans with renal artery stenosis

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