Renal artery flow velocity analysis: a sensitive measure of experimental and clinical renovascular resistance

Norris, Caro; Barnes, Robert W.

doi:10.1016/0022-4804(84)90092-1

Cited by 175 publications

(65 citation statements)

References 7 publications

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“…A high resistive index is associated with a great difference in velocity between the systolic and the diastolic phase that, in part, depends on the degree of peripheral arterial stiffness. 19 Hypertension may cause nephrosclerosis or glomerulosclerosis, reducing the intrarenal vascular surface area and increasing vascular resistance even in the unaffected kidney. 20 The evaluation of RRI in hypertensive patients reveals significantly higher values than normotensive subjects, even without overt nephropathy.…”

Section: Discussionmentioning

confidence: 99%

Renal resistive index and cardiovascular organ damage in a large population of hypertensive patients

et al. 2007

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We evaluated the relationship between renal resistive index (RRI) of the intrarenal vasculature and cardiovascular (CV) organ damage such as left ventricular hypertrophy (LVH), diastolic dysfunction and carotid atherosclerosis in a large sample of hypertensive patients. 566 hypertensive patients underwent echocardiography with conventional Doppler and Doppler tissue imaging (DTI), carotid and renal ultrasonography. In addition, lipids profile, creatinine in serum, and urinary albumin concentrations were determined. The patients were divided according to their RRI values in 2 groups: o70 and X70. Subjects with high RRI were older, had higher systolic and pulse pressure (PP) and more years of hypertension, compared to those with low RRI (Po0.0001). Patients with the higher RRI showed an increased left ventricular mass index (LVMI) and carotid intima-media thickness (IMT) with a higher prevalence of LVH, carotid plaques and microalbuminuria (Po0.001). There were differences in overall diastolic parameters, in particular when evaluated by DTI (Po0.001). A positive correlation was found between RRI and age, PP, carotid IMT, LVMI, SBP and a negative correlation was found with DTI diastolic parameters (Po0.001). Age, PP, carotid IMT and LVMI were independently related to RRI. While, RRI was independently related to IMT and IVRT. RRI, especially the higher values, are positively correlated with target organ damage in hypertensive patients, indicating that renal vascular resistance is related to morphologic and hemodynamic alteration of the CV system. The evaluation of RRI could predict the presence of early CV damage and provide an accurate estimate of overall risk.

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Section: Discussionmentioning

confidence: 99%

Renal resistive index and cardiovascular organ damage in a large population of hypertensive patients

et al. 2007

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“…The intrarenal RI has been assumed to reflect changes in renal vascular resistance [11]. Both frusemide and mannitol reduce renal vascular resistance and increase renal blood flow [12,13], while hyperosmolar radiocontrast agents induce renal vasoconstriction and a decrease in renal blood flow [14].…”

Section: Discussionmentioning

confidence: 99%

Diuretic Doppler ultrasonography in chronic unilateral partial ureteric obstruction in dogs

Yokoyama

Tsuji

2002

BJU International

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Objective To compare the effects of diuresis induced by a loop diuretic (frusemide), an osmotic diuretic (mannitol) and a high-osmolar radio-contrast medium (sodium iothalamate) on the intrarenal resistive index (RI) in dogs with chronic unilateral partial ureteric obstruction (UPUO). Materials and methods The split renal clearance and intrarenal RI were estimated in 11 dogs with chronic UPUO. Doppler ultrasonography measurements of the interlobar arteries were obtained before and 10 min after the intravenous infusion of 1 mg/kg frusemide, 1 g/kg mannitol or 20 mL 60% sodium iothalamate. The same experimental protocol was repeated with another drug at 1-week intervals. Results There was a significant difference between the intrarenal RI of obstructed and unobstructed kidneys in the chronic phase of UPUO. While mannitol and sodium iothalamate significantly increased the RI in both kidneys, differences in RI between the kidneys decreased after infusing the two drugs. However, while frusemide insignificantly increased the RI in the obstructed kidney, it decreased the RI in unobstructed one. Consequently, the difference in RI between the kidneys increased significantly after administering frusemide. There were no significant differences in urinary volume after administering each of the drugs. Conclusions As there were no significant differences in the diuretic effects of the drugs, frusemide may have additional effects on the RI of unobstructed kidneys other than diuresis. Frusemide increased the difference between the intrarenal RI of the kidneys and therefore may improve the detection of unilateral urinary obstruction in humans.

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“…There is good correlation between the progressive increase in renal vascular resistance and the decreased organ perfusion [22]. By Doppler methods, both fetal and uterine blood flow can be measured, thereby permitting an assessment and detection of dysfunction affecting the uteroplacental circulation.…”

Section: Discussionmentioning

confidence: 99%

Fetal renal artery flow and renal echogenicity in the chronically hypoxic state

Surányi¹,

Streitman²,

Pál

et al. 2000

Pediatr Nephrol

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The object of this study was to investigate the fetal renal arterial blood flow in normal and hyperecho-genic kidneys during the third trimester of gestation. The pregnancies screened were all chronically hypoxic. Depending on the etiology of the intrauterine chronic hypoxia, the cases were divided into two study groups. Group I comprised 120 pregnant women with pregnancy-associated hypertension and/or proteinuria. Group II consisted of 87 pregnancies with intrauterine growth retardation. Both study groups included pregnant women from the third trimester. Hyperechogenic renal medullae were detected in 15 out of 120 cases with pregnancyassociated hypertension and/or proteinuria, and in 22 fetuses of the 87 pregnancies involving intrauterine growth retardation. Fetal renal hyperechogenicity appears to be an indicator of fetal arterial circulatory depression, correlated with pathological changes in the resistance index for the fetal renal arteries. The fetal renal arterial blood flow resistance index was significantly lower in hyperechogenic cases. This may also be an in utero indication of subsequent intrauterine and neonatal complications, such as cesarean section because of fetal distress (43%), treatment in a neonatal intensive care unit (51%) or increased perinatal mortality (5.4%, as compared with 0.8-1.0% in the normal population). Detailed ultrasound and Doppler examinations of renal parenchyma and arteries appear to be useful methods in the prenatal diagnosis of reduced renal perfusion and of intrauterine hypoxia to detect possible pathological fetal conditions in utero.

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Renal artery flow velocity analysis: a sensitive measure of experimental and clinical renovascular resistance

Cited by 175 publications

References 7 publications

Renal resistive index and cardiovascular organ damage in a large population of hypertensive patients

Renal resistive index and cardiovascular organ damage in a large population of hypertensive patients

Diuretic Doppler ultrasonography in chronic unilateral partial ureteric obstruction in dogs

Fetal renal artery flow and renal echogenicity in the chronically hypoxic state

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