Renal artery aneurysm associated with Leber hereditary optic neuropathy

Jones, Ruth Ellen; Lee, Jessica; Ali, M. Zulfikar

doi:10.1016/j.jvscit.2017.10.001

Cited by 1 publication

(1 citation statement)

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“…The ratio of different subtypes of optic neuritis (ON) was higher than the other diseases; we analyzed the reason may be our center is the neuro-ophthalmology department, while the other centers are the neurology department. We also found LHON accompanied with IOIS and compression optic neuropathy, which were unreported before; only Jones et al (2018) reported a case of saccular left renal artery aneurysm in a 27-year-old man with known LHON.…”

Section: Discussionsupporting

confidence: 71%

Leber’s hereditary optic neuropathy companied with multiple-related diseases

Sun

Zhou

Sun

et al. 2022

Front. Hum. Neurosci.

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ObjectiveTo elucidate the clinical, radiologic characteristics of Leber’s hereditary optic neuropathy (LHON) associated with the other diseases.Materials and methodsClinical data were retrospectively collected from hospitalized patients with LHON associated with the other diseases at the Neuro-Ophthalmology Department at the Chinese People’s Liberation Army General Hospital (PLAGH) from December 2014 to October 2018.ResultsA total of 13 patients, 24 eyes (10 men and 3 women; mean age, 30.69 ± 12.76 years) with LHON mitochondrial DNA (mtDNA) mutations, were included in the cohort. 14502(5)11778(4)11778 &11696(1)12811(1)11696(1)3460(1). One patient was positive for aquaporin-4 antibody (AQP4-Ab), and two were positive for myelin oligodendrocyte glycoprotein antibody (MOG-Ab). Three patients were associated with idiopathic optic neuritis (ON). Two patients were with compression optic neuropathy. Three patients were with the central nervous system (CNS) diseases. One patient was with proliferative diabetic retinopathy (PDR) and one with idiopathic orbital inflammatory syndrome (IOIS). At the onset, visual acuity (VA) in eighteen eyes was below 0.1, one eye was 0.5, five eyes were above 0.5, while VA in sixteen eyes was below a 0.1 outcome, three eyes experienced moderate vision loss. MRI images showed T2 lesions and enhancement in nine patients who received corticosteroids treatment; additional immune modulators treatment was performed on two patients. None of the patients had relapse during the follow-up time.ConclusionLeber’s hereditary optic neuropathy can be accompanied with multiple-related diseases, especially different subtypes of ON, which were also exhibited with IOIS and compression optic neuropathy for the first time in this cohort. This condition may be a distinct entity with an unusual clinical and therapeutic profile.

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Section: Discussionsupporting

confidence: 71%