Renal and hepatic ALA-D activity and selected oxidative stress parameters of rats exposed to inorganic mercury and organoselenium compounds

Perottoni, Juliano; Rodrigues, Oscar E. D.; Paixão, Márcio W.; Zeni, Gilson; Lobato, Luciana Pereira; Braga, Antônio L.; Rocha, João Batista Teixeira da; Emanuelli, Tatiana

doi:10.1016/j.fct.2003.08.002

Cited by 80 publications

(43 citation statements)

References 55 publications

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“…This also gets support from the fact that selenium blocks the effects of chelating agents in mercury intoxication and the process may be holding good for elimination of mercury from the body in natural course leading to higher accumulation of mercury in the body organs 43) . Our results show high mercury accumulation in kidney than in liver, which is also supported by the other studies 2,4,12,48) . Enhancement of GSH level may be towards the defense mechanism against the effect of ROS in the cell, which was found to be more in selenium post treated animals in liver and kidney tissues rather than its pre treatment.…”

Section: Discussionsupporting

confidence: 81%

“…Mercury exposure has also been demonstrated to induce lipid peroxidation detected by increased thiobarbituric acid reactive substances (TBARS) in liver, kidney, brain and other tissues [7][8][9] . Mercury is known to increase the intracellular levels of reactive oxygen species such as superoxide 10) and hydrogen peroxides 11) , which induce oxidative stress, resulting in tissue damaging effects 12) . Alteration in renal glutathione (GSH) contents is an important feature in the expression of mercury nephrotoxicity 13) .…”

Section: Introductionmentioning

confidence: 99%

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Role of Selenium in Mercury Intoxication in Mice

Agarwal

Behari

2007

Ind Health

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Studies were conducted to examine the effect of pre and post-treatment of selenium in mercury intoxication (20 µ µ µ µ µmole/ kg b.w. each given intraperitoneally) in mice in terms of lipid peroxidation (LPO), glutathione (GSH) content, activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and mercury concentration in liver, kidney and brain. No significant alteration was observed in all the organs examined after mercury or selenium treatment in LPO and GSH but administration of selenium (pre and post) resulted in an increase in the level of LPO and GSH. The activity of SOD was depleted in liver and kidney while that of GPx was lowered in liver of mercury exposed animals. Selenium administration resulted in restoration of the depletion of these enzymatic activities. The activity of CAT in liver and brain was enhanced both in mercury and selenium treated animals. Administration of selenium significantly arrested enhanced CAT activity. Kidney showed the highest mercury concentration among the organs examined. Administration of selenium resulted in further enhancement of mercury concentration in the tissues. An increase in selenium level in liver was observed after mercury treatment, which was also restored by mercury selenium co-administration. Our results indicate that the prooxidant effect of selenium was greater by its pretreatment.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Role of Selenium in Mercury Intoxication in Mice

Agarwal

Behari

2007

Ind Health

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“…Mercury promotes the formation of ROS such as hydrogen peroxides and highly reactive hydroxyl radical by Fenton transition equation, and enhances the subsequent iron and copper-induced production of lipid peroxides. 7 Lipid peroxides alter membrane structure and are highly disruptive of mitochondrial structure and contribute to nephrotoxicity.…”

Section: Discussionmentioning

confidence: 99%

“…5 Mercuric chloride is one of the most toxic forms of mercury because it easily forms organo-mercury complexes with proteins. 6 It is well known as hepatotoxic, 7 neurotoxic, 8 nephrotoxic, 9,10 hematotoxic 11 and genotoxic. 12 In addition, it is reported that mercuric chloride possesses adverse effects on the reproductive system in experimental animals.…”

Section: Introductionmentioning

confidence: 99%

“…19 Selenium is known to possess an affinity constant for mercury higher than that of sulfhydryl compounds and the protection offered by sodium selenite in mercury intoxication has been attributed to the formation of Hg-Se-S complex which is stated to be non-toxic. 7 Taurine is a sulfur-containing amino acid that conjugates with bile acids in the liver and chemically similar to acetylcysteine, an agent for treating the heavy metal intoxication. 22 Taurine plays an important role in reducing the toxic effect of copper, lead, cadmium, oxidized fish oil, oxidized cholesterol and vitamin A in rats.…”

Section: Introductionmentioning

confidence: 99%

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Nephroprotective potential of selenium and taurine against mercuric chloride induced nephropathy in rats

et al. 2014

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Department of Hormones, National Research Centre, Cairo, Egypt AbstractThe study was aimed to estimate whether pre-treatment with sodium selenite or taurine would reverse kidney damage induced by intraperitoneal injection of mercuric chloride in rats. Animals were divided into six groups: (1) control group; (2) sodium selenite group; (3) taurine group; (4) HgCl 2 group; (5) sodium selenite pretreated group; (6) taurine pretreated group. The results demonstrated that HgCl 2 causes significant enhancement in serum malondialdehyde (MDA), creatinine, N-acetyl-beta-D-glucosaminidase (NAG), cystatin C, nephrin and interleukin 6 (IL-6) levels accompanied with significant reduction in serum nitric oxide (NO) level. Pretreatment with sodium selenite or taurine produces significant depletion in MDA, NAG, cystatin C, nephrin and IL-6 levels in concomitant with significant elevation in serum NO level as compared to HgCl 2 group. HgCl 2 induced pathological alterations in the kidney. The ultrastructural investigation of renal cortex of HgCl 2 -administered group revealed that the glomerular basement membrane is uniform, the fenestrations of endothelial cells are swollen, and the secondary foot processes appear also swollen even fused at some points. The proximal convoluted tubules showed apical short and few microvilli, while, some tubular cells showed relatively normal microvilli. In contrast, sodium selenite or taurine pretreatment could significantly reduce the pathological alterations in the kidney caused by HgCl 2 intoxication. The current results suggested that selenium and taurine possess nephroprotective efficacy due to their antioxidative capacity and anti-inflammatory activity.

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Organoselenium and organotellurium compounds: Toxicology and pharmacology

Nogueira

Rocha

2011

Patai's Chemistry of Functional Groups

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In the last three decades, the interest in the field of synthesis and reactivity of organoselenium and organotellurium compounds has increased; particularly, in view of the observations that they can exhibit important biological activities. The data presented in this chapter clearly indicate the potential pharmacological and therapeutic uses of organoselenium and organotellurium compounds. Indeed, these classes of molecules exhibit a variety of interesting biological effects, namely antioxidant properties, which can account for their in vitro and in vivo beneficial effects in a wide range of models of different human pathologies. We can conclude that the future of “medicinal chemistry“ of organoselenium and organotellurium compounds will depend on the rational development of new molecules, which can be guided by chemical and biological approaches. Moreover, the structure‐activity relationship for a given class of organoselenium or organotellurium compounds should be used as a toll for screening molecules with high probability of exhibiting low toxicity and high pharmacological activity in mammals.

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Renal and hepatic ALA-D activity and selected oxidative stress parameters of rats exposed to inorganic mercury and organoselenium compounds

Cited by 80 publications

References 55 publications

Role of Selenium in Mercury Intoxication in Mice

Role of Selenium in Mercury Intoxication in Mice

Nephroprotective potential of selenium and taurine against mercuric chloride induced nephropathy in rats

Organoselenium and organotellurium compounds: Toxicology and pharmacology

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