Renal and cardiorespiratory effects of treatment with lactated Ringer's solution or physiologic saline (0.9% NaCl) solution in cats with experimentally induced urethral obstruction

Abstract

Treatment with LRS or PSS appeared to be safe and effective in cats with experimentally induced UO; however, LRS was more efficient in restoring the acid-base and electrolyte balance in severely decompensated cats with UO.

Controversies in the management of feline urethral obstruction

“…One study comparing 0.9% NaCl and a balanced electrolyte solution (Normosol R) in clinical UO patients showed no difference in outcome (survival, length of stay) or in reduction of serum potassium concentrations, though acid–base abnormalities corrected more rapidly in the Normosol R group . Another study used a model of experimentally induced feline UO to create a more uniformly and severely affected population (mean BUN of 99.2 mmol/L [278 mg/dL], creatinine of 663 μmol/L [7.5 mg/dL] versus BUN of 14.3–17.9 mmol/L [40–50 mg/dL], creatinine of 247.5–318.2 μmol/L [2.8–3.6 mg/dL] in the previous study) to compare administration of 0.9% NaCl versus lactated Ringer's solution . Similarly, this study found more rapid improvement of acid–base values with lactated Ringer's, but no difference in clinical outcome, decrease in potassium, or decrease in renal values.…”

Peritoneum

“…Although some clinicians use 0.9% NaCl to avoid administering potassium, it is clear that more balanced electrolyte solutions (lactated Ringer's, Normasol R) allow for a more rapid correction of acid-base status without affecting normalization of serum potassium levels. 69,70 In cases of marked hyperkalemia, calcium gluconate (a functional antagonist of potassium) should be administered slowly, intravenously (0.5 mL/kg). Although it does not lower serum potassium, calcium changes the threshold potential and returns membrane excitability to normal for approximately 20 to 30 minutes.…”

Fluid Therapy Rate in Postrenal Azotemia Stabilization in Cats

“…This study was a pilot study from two other studies [8,9]. Fifteen neutered male adult mixed breed cats (weight range 3 to 5 kg) were housed in individual cages, fed dry commercial food and water was available ad libitum.…”

“…The animals were submitted to a urethral obstruction model [8,9] (parallel study) and submitted to the anesthetic for relieving of urethral obstruction when any 3 of 4 clinic pathologic criteria were met: venous pH < 7.2, BUN concentration > 200 mg/ dL, serum creatinine concentration > 4.5 mg/ dL, and serum potassium concentration > 6.5 mEq/ L.…”

“…There is not yet a consensus about the ideal rate of fluid therapy after relief of UO. Suggestions range between 10-90ml/kg/h for initial therapy in severe cases [1,4,7].The aim of the present paper was to alert veterinary clinicians about the influence of high rate of fluid therapy in the stabilization of cats with UO.This study was a pilot study from two other studies [8,9]. Fifteen neutered male adult mixed breed cats (weight range 3 to 5 kg) were housed in individual cages, fed dry commercial food and water was available ad libitum.…”