Renal Amyloidosis in Relation to Renal Insufficiency

Renal Amyloidosis Presenting as Water Losing Syndrome

“…The thrombi have their origin in the small renal veins: in such cases, there is often a sudden terminal, deteriora tion, as in our patient I. A thrombosis may however originate in the vena cava and cause a long-standing nephrotic syndrome, even in the absence o f renal amyloidosis (6). There is evidence to suggest that renal vein thrombosis was responsible for the acute episode in pa tient II.…”

“…There may be no apparent renal abnormality, or the disease may present itself as a simple proteinuria, a nephrotic syndrome or a generalized renal fail ure. The only fact of differential diagnostic importance may be the relative absence of hypertension (4,6,14,15,16).…”

“…The biopsy led to the diagnosis in both patients and to surgical exploration of an unsuspected abcess in one o f them. Several reports in the literature, including large series, do not mention early loss o f concentrating power as a symptom of renal amyloidosis (1,6,14). Some papers even stress the preservation o f the concentrating ability (3,4).…”

“…The diagnosis of renal amyloidosis is not infrequently first made by renal biopsy or at postmortem examination (6,9,14). The clinical characteristics are not pathognomonic, as it is well established that the disease can present itself as nephrotic syndrome, simple protein uria or generalized renal failure (6,14,15).…”

“…The clinical characteristics are not pathognomonic, as it is well established that the disease can present itself as nephrotic syndrome, simple protein uria or generalized renal failure (6,14,15).…”