Renal amyloidosis: an update on diagnosis and pathogenesis

Gupta, Nimisha; Kaur, Harpreet; Wajid, Saima

doi:10.1007/s00709-020-01513-0

Cited by 40 publications

(29 citation statements)

References 96 publications

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“…En la AAH, la β2M es el componente principal de la brilla de amiloide. La β2M es un componente proteico que forma parte del complejo mayor de histocompatibilidad de tipo I [13,14]. Más del 95 % de la β2M circulante es eliminada mediante el ltrado glomerular (FG) y, posteriormente, una parte importante es reabsorbida y degradada en el túbulo proximal; por lo tanto, los niveles de dicha proteína aumentan en el marco de ERC y hemodiálisis [15].…”

Section: Fisiopatologíaunclassified

“…Las afecciones extraarticulares son menos frecuentes y ocurren generalmente después de aproximadamente nueve años (o más) del inicio de la hemodiálisis. Los órganos más afectados son: el corazón en el 80 % de los casos; el tracto digestivo en el 78 % de los casos; el sistema respiratorio en el 59 % de los casos; el hígado y los riñones en un 41 % y un 33 % respectivamente, y en menor frecuencia el bazo, en un 5 % de los casos [13].…”

Section: Manifestaciones Clínicasunclassified

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Amiloidosis Asociada a Hemodiálisis: Revisión Literaria

Bohórquez-Rivero

Sanchez-Martínez

Brieva-Deulofeut

et al. 2021

Rev. Colomb. Nefrol.

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La amiloidosis constituye una complicación importante en los pacientes con enfermedad renal crónica terminal que son sometidos a hemodiálisis durante extensos períodos de tiempo. Al igual que en otras amiloidosis sistémicas, la amiloidosis asociada a hemodiálisis está formada por diferentes sustancias, algunas de ellas de carácter fibrilar, como la ?eta-2-microglobulina, la cual representa una de las proteínas de mayor relevancia dada su implicación etiopatogénica. A pesar de que las técnicas de hemodiálisis han sido mejoradas con el paso de los años, dicha entidad continúa siendo una complicación relativamente frecuente; tal es que se puede presentar hasta en el 80% de los pacientes con hemodiálisis prolongadas. Por lo tanto, se hizo imprescindible realizar una revisión narrativa partiendo de la literatura científica disponible en las diferentes bases de datos con el objetivo de contribuir a mejorar y actualizar el conocimiento del médico en dicho tópico; abarcando desde los aspectos generales y su fisiopatología, hasta su presentación clínica, diagnóstico, y tratamiento.

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Section: Fisiopatologíaunclassified

Section: Manifestaciones Clínicasunclassified

Amiloidosis Asociada a Hemodiálisis: Revisión Literaria

Bohórquez-Rivero

Sanchez-Martínez

Brieva-Deulofeut

et al. 2021

Rev. Colomb. Nefrol.

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“…Importantly, several conditions encountered in hematologic patients are accompanied by nephrotic syndrome and, thus, are probable causes of spurious hyponatremia in the context of hyperlipidemia ( Table 1 ). The main underlying mechanisms of nephrotic syndrome-related hyperlipidemia are the increased hepatic biosynthesis as well as the decreased clearance of cholesterol and major lipoproteins, triggered by the decrease in oncotic pressure due to loss of proteins in urine [ 30 , 31 , 32 , 33 ].…”

Section: Causes Of Hyponatremia In Hematologic Patientsmentioning

confidence: 99%

Hyponatremia in Patients with Hematologic Diseases

Koumpis

Florentin

Hatzimichael

et al. 2020

JCM

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Hyponatremia is the most common electrolyte disorder in clinical practice and is associated with increased morbidity and mortality. It is frequently encountered in hematologic patients with either benign or malignant diseases. Several underlying mechanisms, such as hypovolemia, infections, toxins, renal, endocrine, cardiac, and liver disorders, as well as the use of certain drugs appear to be involved in the development or the persistence of hyponatremia. This review describes the pathophysiology of hyponatremia and discusses thoroughly the contributing factors and mechanisms that may be encountered specifically in patients with hematologic disorders. The involvement of the syndrome of inappropriate antidiuretic hormone (SIADH) secretion and renal salt wasting syndrome (RSWS) in the development of hyponatremia in such patients, as well as their differential diagnosis and management, are also presented. Furthermore, the distinction between true hyponatremia and pseudohyponatremia is explained. Finally, a practical algorithm for the evaluation of hyponatremia in hematologic patients, as well as the principles of hyponatremia management, are included in this review.

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“…Amyloidosis can cause systemic or local lesions; kidney was the most commonly affected organ by systemic amyloidosis [ 2 , 3 , 4 ]. Renal amyloidosis is a rare and intractable protein misfolding disorder which prompts progressive renal insufficiency [ 5 ]. The common forms of systemic amyloidosis include immunoglobulin light chain amyloidosis (AL), amyloid A amyloidosis (AA) and leukocyte chemotactic factor 2 (LECT2) amyloidosis.…”

Section: Introductionmentioning

confidence: 99%

A Pilot Study of Rare Renal Amyloidosis Based on FFPE Proteomics

Meng

Xia

et al. 2021

Molecules

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Renal amyloidosis typically manifests albuminuria, nephrotic-range proteinuria, and ultimately progresses to end-stage renal failure if diagnosed late. Different types of renal amyloidosis have completely different treatments and outcomes. Therefore, amyloidosis typing is essential for disease prognosis, genetic counseling and treatment. Thirty-six distinct proteins currently known to cause amyloidosis that have been described as amyloidogenic precursors, immunohistochemistry (IHC) or immunofluorescence (IF), can be challenging for amyloidosis typing especially in rare or hereditary amyloidosis in clinical practice. We made a pilot study that optimized the proteomics pre-processing procedures for trace renal amyloidosis formalin-fixed paraffin-embedded (FFPE) tissue samples, combined with statistical and bioinformatics analysis to screen out the amyloidosis-related proteins to accurately type or subtype renal amyloidosis in order to achieve individual treatment. A sensitive, specific and reliable FFPE-based proteomics analysis for trace sample manipulation was developed for amyloidosis typing. Our results not only underlined the great promise of traditional proteomics and bioinformatics analysis using FFPE tissues for amyloidosis typing, but also proved that retrospective diagnosis and analysis of previous cases laid a solid foundation for personalized treatment.

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Renal amyloidosis: an update on diagnosis and pathogenesis

Cited by 40 publications

References 96 publications

Amiloidosis Asociada a Hemodiálisis: Revisión Literaria

Amiloidosis Asociada a Hemodiálisis: Revisión Literaria

Hyponatremia in Patients with Hematologic Diseases

A Pilot Study of Rare Renal Amyloidosis Based on FFPE Proteomics

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