Renal amyloidosis

Jazbeh, Sammer; Said, Albara; Haddad, Rami Y.; Hamad, Amar; Lerma, Edgar V.

doi:10.1016/j.disamonth.2014.08.003

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…No correlation was found between the amyloid deposition in interstitium and the level of proteinuria in the present study. A similar relationship between the amylin deposition pattern and proteinuria level has been reported in previous studies [10,12,[16][17][18] . For instance, a retrospective study of 68 cases of renal amyloid A amyloidosis revealed that a low proteinuria level correlates with vascular amylin deposition, whereas a high proteinuria level correlates with amyloid deposition in the glomerular mesangiocapillary regions [16] .…”

Section: Discussionsupporting

confidence: 82%

Clinicopathological features of renal amyloidosis: A single-center study on 47 cases

Chen

Zhang

et al. 2015

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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The correlations between the clinicopathological features and the long-term outcomes of renal amyloidosis (RA) were analyzed with a view to develop strategies for improving diagnosis and prognosis of RA. We retrospectively reviewed the clinicopathological characteristics of 47 patients diagnosed with RA between 2004 and 2014 at the Wuhan Union Hospital. The data on the renal histology, clinical manifestations, and prognosis of RA patients were retrieved from the hospital records and characteristic patterns were identified. The histological changes in the kidneys were correlated with the clinical manifestations of RA. Additionally, most RA patients in this study had decreased serum levels of κ light chain and increased urine levels of κ and λ light chains as well as presence of M-protein in the urine and serum. Patients with early RA showed no specific pathognomonic symptoms. Bleeding associated with diagnostic renal biopsy was rare. We recommend that the routine work-up of patients aged over 40 years and presenting with non-diabetic nephropathy includes the non-invasive tests for the measurement of serum and urine levels of κ and λ light chains as well as protein electrophoresis tests for the presence of urinary and serum M-protein. Additionally, such patients should undergo renal biopsy screening with Cong-red staining to ensure early diagnosis of RA and improve their survival, since the risk of hemorrhage related to renal biopsy screening is low at early stages of RA.

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Section: Discussionsupporting

confidence: 82%

Clinicopathological features of renal amyloidosis: A single-center study on 47 cases

Chen

Zhang

et al. 2015

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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“…12,13 Rarely, tubular involvement by amyloid can lead to Fanconi syndrome or nephrogenic diabetes insipidus. 14 Clinically, more than 75% of patients with renal amyloidosis present with peripheral edema; this is due to nephrotic syndrome, renal failure, heart failure, or a combination of these. 8 Hypotension is commonly seen in patients with autonomic dysfunction or advanced heart failure and can contribute to progressive renal dysfunction.…”

Section: Clinical Featuresmentioning

confidence: 99%

Renal Amyloidosis: Presentation, Diagnosis, and Management

Gurung

2022

The American Journal of Medicine

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“…AL amyloidosis is most commonly deposited in the glomeruli, and the majority of patients present with proteinuria within the nephrotic range. In contrast, if amyloid is deposited in the renal tubules or renal vessels, there is little proteinuria[ 14 ]. The uniqueness of our case was that amyloid deposits were extensive, involving both glomerular and interstitial tubules, as well as some of the small renal arteries.…”

Section: Discussionmentioning

confidence: 99%

Membranous nephropathy with systemic light-chain amyloidosis of remission after rituximab therapy: A case report

Zhang¹,

Wang²,

Zou³

et al. 2023

World J Clin Cases

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Hepatocellular carcinoma (HCC) is one of the most prevalent tumors worldwide and the leading contributor to cancer-related deaths. The progression and metastasis of HCC are closely associated with altered mitochondrial metabolism, including mitochondrial stress response. Mitokines, soluble proteins produced and secreted in response to mitochondrial stress, play an essential immunomodulatory role. Immunotherapy has emerged as a crucial treatment option for HCC. However, a positive response to therapy is typically dependent on the interaction of tumor cells with immune regulation within the tumor microenvironment. Therefore, exploring the specific immunomodulatory mechanisms of mitokines in HCC is essential for improving the efficacy of immunotherapy. This study provides a comprehensive overview of the association between HCC and the immune microenvironment and highlights recent progress in understanding the involvement of mitochondrial function in preserving liver function. In addition, a systematic review of mitokines-mediated immunomodulation in HCC is presented. Finally, the potential diagnostic and therapeutic roles of mitokines in HCC are prospected and summarized. Recent progress in mitokine research represents a new prospect for mitochondrial therapy. Considering the potential of mitokines to regulate immune function, investigating them as a relevant molecular target holds great promise for the diagnosis and treatment of HCC.

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Renal amyloidosis

Cited by 6 publications

References 19 publications

Clinicopathological features of renal amyloidosis: A single-center study on 47 cases

Clinicopathological features of renal amyloidosis: A single-center study on 47 cases

Renal Amyloidosis: Presentation, Diagnosis, and Management

Membranous nephropathy with systemic light-chain amyloidosis of remission after rituximab therapy: A case report

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