Renal allograft recipients with high susceptibility to cutaneous malignancy have an increased prevalence of human papillomavirus DNA in skin tumours and a greater risk of anogenital malignancy

Arends, Mark J.; Benton, E. C.; McLaren, K M; Stark, Lesley A.; Hunter, John; Bird, C. C.

doi:10.1038/bjc.1997.128

Cited by 80 publications

(41 citation statements)

References 37 publications

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“…In addition, the increased incidence of CIN and cervical cancer among immunosuppressed persons strongly suggests that the immune responses play an important role in disease development (27,28). Moreover, there is accumulating evidence that the cellular immune response, but not the humoral immune response, is impaired in HPV infections compared with that in normal cervical tissues (29,30).…”

mentioning

confidence: 99%

Both E6 and E7 Oncoproteins of Human Papillomavirus 16 Inhibit IL-18-Induced IFN-γ Production in Human Peripheral Blood Mononuclear and NK Cells

Lee

Cho

et al. 2001

The Journal of Immunology

107

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Cervical carcinoma is the predominant cancer among malignancies in women throughout the world, and human papillomavirus (HPV) 16 is the most common agent linked to human cervical carcinoma. The present study was performed to investigate the mechanisms of immune escape in HPV-induced cervical cancer cells. The presence of HPV oncoproteins E6 and E7 in the extracellular fluids of HPV-containing cervical cancer cell lines SiHa and CaSki was demonstrated by ELISA. The effect of HPV 16 oncoproteins E6 and E7 on the production of IFN-γ by IL-18 was assessed. E6 and E7 proteins reduced IL-18-induced IFN-γ production in both primary PBMCs and the NK0 cell line. FACS analysis revealed that the viral oncoproteins reduced the binding of IL-18 to its cellular surface receptors on NK0 cells, whereas there was no effect of oncoproteins on IL-1 binding to its surface IL-1 receptors on D10S, a subclone of the murine Th cell D10.G4.1. In vitro pull-down assays also revealed that the viral oncoproteins and IL-18 bound to IL-18R α-chain competitively. These results suggest that the extracellular HPV 16 E6 and E7 proteins may inhibit IL-18-induced IFN-γ production locally in HPV lesions through inhibition of IL-18 binding to its α-chain receptor. Down-modulation of IL-18-induced immune responses by HPV oncoproteins may contribute to viral pathogenesis or carcinogenesis.

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mentioning

confidence: 99%

Both E6 and E7 Oncoproteins of Human Papillomavirus 16 Inhibit IL-18-Induced IFN-γ Production in Human Peripheral Blood Mononuclear and NK Cells

Lee

Cho

et al. 2001

The Journal of Immunology

107

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show abstract

“…The incidence of HPV-induced diseases is increased in T-cell immunodeficient individuals, such as HIV-infected (Sun et al, 1997), transplanted patients (Arends et al, 1997), patients treated by immunosuppressive drugs (Ulrich et al, 2008) or in primary immunodeficiencies (Lawrence et al, 2005). In patients with high-grade CIN 2/3 or invasive cervical carcinoma, blood cytotoxic T lymphocytes (CTL) directed against HPV-16 E6 or E7 proteins are barely detectable (Nakagawa et al, 1997(Nakagawa et al, , 2000.…”

Section: Cellular Immune Response After Hpv Infectionmentioning

confidence: 99%

Current Insight into Anti-HPV Immune Responses and Lessons for Prophylactic and Therapeutic Vaccines

Bourgault‐Villada¹,

Jacobelli²

2012

Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

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Section: Cellular Immune Response After Hpv Infectionmentioning

confidence: 99%

Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

Broeck¹

2012

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Renal allograft recipients with high susceptibility to cutaneous malignancy have an increased prevalence of human papillomavirus DNA in skin tumours and a greater risk of anogenital malignancy

Cited by 80 publications

References 37 publications

Both E6 and E7 Oncoproteins of Human Papillomavirus 16 Inhibit IL-18-Induced IFN-γ Production in Human Peripheral Blood Mononuclear and NK Cells

Both E6 and E7 Oncoproteins of Human Papillomavirus 16 Inhibit IL-18-Induced IFN-γ Production in Human Peripheral Blood Mononuclear and NK Cells

Current Insight into Anti-HPV Immune Responses and Lessons for Prophylactic and Therapeutic Vaccines

Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

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