Renal allograft eosinophilia: An unusual presentation of sudden graft dysfunction

Yuvaraj, Anand; Ghosh, Souvik; Abraham, Georgi; Koshy, Priyanka

doi:10.4103/0971-4065.179321

Cited by 2 publications

(1 citation statement)

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“…Although eosinophilic infiltration represents a remarkable positive prognostic indicator in tumors (lung, gastric, Hodgkin's disease), it has not been so with renal allograft. [ 9 10 ] The role and prognostic significance of eosinophils in graft have not been fully elucidated. Few studies have even implied a poor graft outcome or corticosteroid resistant rejection.…”

Section: Discussionmentioning

confidence: 99%

Early eosinophilic antibody-mediated rejection in a renal allograft recipient

et al. 2018

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Although the predominant component of acute allograft rejection is the T-cells, the milieu is not devoid of other inflammatory cells including plasma cells, eosinophils, and histiocytes. Apart from the CD8 T cell and CD4 T cell-FasL cytotoxicity, experimental models had proven a pivotal role of Th-2 cells in acute rejection, and these have been associated with marked tissue eosinophilia. Herein, we present a unique case of severe eosinophilic acute antibody-mediated rejection in a 22 years old deceased donor renal allograft recipient, within 4 days of transplantation without peripheral eosinophilia. The pathology was successfully dealt with the prevailing modalities of therapy, including steroids, plasmapheresis, intravenous immunoglobulin, and bortezomib. Concurrently, we have briefly reviewed the literature about the role of eosinophils in graft rejection and its prognostication.

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Section: Discussionmentioning

confidence: 99%