Removing interictal fast ripples on electrocorticography linked with seizure freedom in children

Wu, Joyce; Sankar, Raman; Lerner, Jason T.; Matsumoto, Joyce H.; Vinters, Harry V.; Mathern, Gary W.

doi:10.1212/wnl.0b013e3181fc27d0

Cited by 289 publications

(290 citation statements)

References 22 publications

(11 reference statements)

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“…Subsequent studies have demonstrated that HFOs can be reliably recorded using commercially-available macroelectrodes, both subdural and depth electrodes, with the highest rates during slow-wave NREM sleep. They were found to be an independent epilepsy marker both in neocortical epilepsy and mTLE [17][18][19][20][21][22]. The regions showing high rates of interictal or ictal HFOs spatially colocalize with the SOZ or EZ, and resection of areas with higher interictal or ictal HFO rates have been significantly associated with a better surgical outcome (Table 1).…”

Section: High-frequency Oscillationsmentioning

confidence: 99%

Advances of Intracranial Electroencephalography in Localizing the Epileptogenic Zone

Jin

Wang

2016

Neurosci. Bull.

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Intracranial electroencephalography (iEEG) provides the best precision in estimating the location and boundary of an epileptogenic zone. Analysis of iEEG in the routine EEG frequency range (0.5-70 Hz) remains the basis in clinical practice. Low-voltage fast activity is the most commonly reported ictal onset pattern in neocortical epilepsy, and low-frequency high-amplitude repetitive spiking is the most commonly reported ictal onset pattern in mesial temporal lobe epilepsy. Recent studies using wideband EEG recording have demonstrated that examining higher (80-1000 Hz) and lower (0.016-0.5 Hz) EEG frequencies can provide additional diagnostic information and help to improve the surgical outcome. In addition, novel computational techniques of iEEG signal analysis have provided new insights into the epileptic network. Here, we review some of these recent advances. Although these sophisticated and advanced techniques of iEEG analysis show promise in localizing the epileptogenic zone, their utility needs to be further validated in larger studies.

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Section: High-frequency Oscillationsmentioning

confidence: 99%

Advances of Intracranial Electroencephalography in Localizing the Epileptogenic Zone

Jin

Wang

2016

Neurosci. Bull.

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“…HFOs occur in limbic structures such as the hippocampus and entorhinal cortex, as well as in the neocortex, and they are thought to reflect the activity of dysfunctional neural networks that underlie and sustain epileptogenesis (Bragin et al, 2004;Jacobs et al, 2009Jacobs et al, , 2010Ibarz et al, 2010;Jiruska et al, 2010a;Wu et al, 2010;Lévesque et al, 2011). HFOs are also better markers than interictal spikes to identify the seizure-onset zone, independently of the underlying pathology (Jacobs et al, 2008(Jacobs et al, , 2009Crépon et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Two Seizure-Onset Types Reveal Specific Patterns of High-Frequency Oscillations in a Model of Temporal Lobe Epilepsy

2012

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High-frequencyoscillations(HFOs;80 -500Hz)arethoughttomirrorthepathophysiologicalchangesoccurringinepilepticbrains.However,the distribution of HFOs during seizures remains undefined. Here, we recorded from the hippocampal CA3 subfield, subiculum, entorhinal cortex, and dentate gyrus to quantify the occurrence of ripples (80 -200 Hz) and fast ripples (250 -500 Hz) during low-voltage fast-onset (LVF) and hypersynchronous-onset (HYP) seizures in the rat pilocarpine model of temporal lobe epilepsy. We discovered in LVF seizures that (1) progressionfrompreictaltoictalactivitywascharacterizedinseizure-onsetzonesbyanincreaseofrippleratesthatwerehigherwhencomparedwithfast ripple rates and (2) ripple rates during the ictal period were higher compared with fast ripple rates in seizure-onset zones and later in regions of secondary spread. In contrast, we found in HYP seizures that (1) fast ripple rates increased during the preictal period and were higher compared with ripple rates in both seizure-onset zones and in regions of secondary spread and (2) they were still higher compared with ripple rates in both seizure-onset zones and regions of secondary spread during the ictal period. Our findings demonstrate that ripples and fast ripples show distinct time-and region-specific patterns during LVF and HYP seizures, thus suggesting that they play specific roles in ictogenesis.

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“…HFOs were successively described in stereo-EEG (SEEG) of epileptic patients acquired using clinical macroelectrodes (surface contact: 0.8 mm 2 ), occurring during the ictal phase particularly in the seizure onset zone (SOZ) . Further studies showed that HFOs can be recorded in the interictal phase, still more commonly in the SOZ (Urrestarazu et al, 2007;Jacobs et al, 2008;Worrell et al, 2008); they can be linked to epileptogenic lesions (Staba et al, 2007), being non-specific to a particular type of lesion, representing epileptogenicity per se ; they appear to predict the outcome after epilepsy surgery, in adults (Jacobs et al, 2010) as in children (Wu et al, 2010). HFOs are not confined to mesial temporal structures, occurring also in neocortical regions, usually at lower rates (Urrestarazu et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Continuous High Frequency Activity: A peculiar SEEG pattern related to specific brain regions

Melani

Zelmann

Mari

et al. 2013

Clinical Neurophysiology

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Objective-While visually marking the high frequency oscillations in the stereo-EEG of epileptic patients, we observed a continuous/semicontinuous activity in the ripple band (80-250 Hz), which we defined continuous High Frequency Activity (HFA). We aim to analyze in all brain regions the occurrence and significance of this particular pattern.Methods-Twenty patients implanted in mesial temporal and neocortical areas were studied. One minute of slow-wave sleep was reviewed. The background was classified as continuous/ semicontinuous, irregular, or sporadic based on the duration of the fast oscillations. Each channel was classified as inside/outside the seizure onset zone (SOZ) or a lesion.Results-The continuous/semicontinuous HFA occurred in 54 of the 790 channels analyzed, with a clearly higher prevalence in hippocampus and occipital lobe. No correlation was found with the SOZ or lesions. In the occipital lobe the continuous/semicontinuous HFA was present independently of whether eyes were open or closed. Conclusions-We describe what appears to be a new physiological High Frequency Activity, independent of epileptogenicity, present almost exclusively in the hippocampus and occipital cortex but independent of the alpha rhythm.Significance-The continuous HFA may be an intrinsic characteristic of specific brain regions, reflecting a particular type of physiological neuronal activity.

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Removing interictal fast ripples on electrocorticography linked with seizure freedom in children

Abstract: Background: Fast ripples (FR, 250-500 Hz) detected with chronic intracranial electrodes are

Cited by 289 publications

References 22 publications

Advances of Intracranial Electroencephalography in Localizing the Epileptogenic Zone

Advances of Intracranial Electroencephalography in Localizing the Epileptogenic Zone

Two Seizure-Onset Types Reveal Specific Patterns of High-Frequency Oscillations in a Model of Temporal Lobe Epilepsy

Continuous High Frequency Activity: A peculiar SEEG pattern related to specific brain regions

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