REMOVED: Sleep deprivation exacerbates concussive head injury induced brain pathology: Neuroprotective effects of nanowired delivery of cerebrolysin with α-melanocyte-stimulating hormone

Sharma, Aruna; Mureșanu, Dafin F.; Ozkızılcık, Asya; Tian, Z. Ryan; Lafuente, José Vicente; Manzhulo, Igor; Mössler, Herbert; Sharma, Hari Shanker

doi:10.1016/bs.pbr.2019.03.002

Cited by 24 publications

(1 citation statement)

References 236 publications

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“…[7] Sleep deprivation, commonly experienced by military personnel, can exacerbate brain pathology, especially when coupled with concussive head injury (CHI). [33,86] In a randomized, double-blind, and placebo-controlled trial of melatonin treatment examining 62 pediatric patients with postconcussion symptoms, the study reveals increased functional connectivity in posterior default mode network regions and altered gray matter volume. [45] Comparing healthy controls and individuals with mTBI, it was observed that control participants had higher physical activity and lower sleep time compared to the mTBI group.…”

Section: Exercisementioning

confidence: 99%

The importance of behavioral interventions in traumatic brain injury

Buccilli,

Alan,

Baha’

et al. 2024

Surgical Neurology International

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Background: Traumatic brain injury (TBI) poses a significant public health concern, profoundly impacting individuals and society. In this context, behavioral interventions have gained prominence as crucial elements in TBI management, addressing the diverse needs of TBI-affected individuals. Methods: A comprehensive literature search was conducted, utilizing databases such as PubMed, Embase, and Scopus. Inclusion criteria encompassed studies focusing on behavioral interventions in TBI, with a particular emphasis on their impact on outcomes. Relevant articles published within the past decade were prioritized, and a qualitative synthesis of the findings was performed. Results: Behavioral interventions have demonstrated their effectiveness in addressing various aspects of TBI care. They have been instrumental in improving cognitive functions, emotional stability, and adaptive behaviors among TBI patients. However, it is important to acknowledge that challenges still exist, including issues related to clinical heterogeneity and healthcare disparities. Conclusion: The integration of behavioral interventions into standard clinical practice marks a transformative shift in TBI care. This approach holds immense potential for enhancing patient outcomes and elevating the overall quality of life for individuals grappling with the complexities of this condition. This review serves as a clarion call for healthcare practitioners, researchers, and policymakers to recognize the pivotal role of behavioral interventions in TBI care, advocating for their wider adoption to advance the field toward a more holistic and patient-centric approach.

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Section: Exercisementioning

confidence: 99%