Removal of the Olfactory Bulbs in Mice Leads to Changes in Affective Behavior

Nedogreeva, O. A.; Stepanichev, M. Yu.; Gulyaeva, N. V.

doi:10.1007/s11055-020-00982-3

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…Moreover, the MCAO-KM and MCAO-LM rats exhibited increased swimming activity and/or active strategies to cope with the water immersion stress. We have previously shown that induced hyperactivity in a model of agitated depression induced by bulbectomy may lead to the misinterpretation of animal behavior in tests for anxiety and depression [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Two Models of Intraluminal Filament Middle Cerebral Artery Occlusion in Rats: Long-Lasting Accumulation of Corticosterone and Interleukins in the Hippocampus and Frontal Cortex in Koizumi Model

et al. 2022

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Recently, we have shown the differences in the early response of corticosterone and inflammatory cytokines in the hippocampus and frontal cortex (FC) of rats with middle cerebral artery occlusion (MCAO), according to the methods of Longa et al. (LM) and Koizumi et al. (KM) which were used as alternatives in preclinical studies to induce stroke in rodents. In the present study, corticosterone and proinflammatory cytokines were assessed 3 months after MCAO. The most relevant changes detected during the first days after MCAO became even more obvious after 3 months. In particular, the MCAO-KM (but not the MCAO-LM) group showed significant accumulation of corticosterone and IL1β in both the ipsilateral and contralateral hippocampus and FC. An accumulation of TNFα was detected in the ipsilateral hippocampus and FC in the MCAO-KM group. Thus, unlike the MCAO-LM, the MCAO-KM may predispose the hippocampus and FC of rats to long-lasting bilateral corticosterone-dependent distant neuroinflammatory damage. Unexpectedly, only the MCAO-LM rats demonstrated some memory deficit in a one-trial step-through passive avoidance test. The differences between the two MCAO models, particularly associated with the long-lasting increase in glucocorticoid and proinflammatory cytokine accumulation in the limbic structures in the MCAO-KM, should be considered in the planning of preclinical experiments, and the interpretation and translation of received results.

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Section: Discussionmentioning

confidence: 99%