Abstract:ObjectiveThe endothelial surface layer (ESL), a layer of macromolecules on the surface of endothelial cells, can both impede and facilitate leukocyte recruitment. However, its role in monocyte and neutrophil recruitment in glomerular capillaries is unknown.MethodsWe used multiphoton intravital microscopy to examine monocyte and neutrophil behavior in the glomerulus following ESL disruption with hyaluronidase.ResultsConstitutive retention and migration of monocytes and neutrophils within the glomerular microvas… Show more
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