Removal of<sup>239</sup>Pu, Internally Deposited in Mice, by Means of Diethylenetriaminepentamethylenephosphonates

Szot, Z.; Zablotna, R.; Geisler, Jan; Poczynajlo, A.

doi:10.1080/09553007814550761

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1983

1986

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Removal of239Pu from mice with 3,4,3 LICAM(C) or N, N?, N?, N?-tetra-(2,3-dihydroxybenzoyl)-spermine

Szot

Rochalska

Wojewódzka

et al. 1986

Radiat Environ Biophys

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Male mice SAS/4 were injected i.v. with 239Pu citr(IV) 0.27 microCi . kg-1-9.99 kBq X kg-1. After 1 h 30 mumol . kg-1 of 3,4,3 LICAM(C), N,N',N'',N'''-tetra-(2,3-dihydroxybenzoyl)-spermine or Na3CaDTPA as a reference compound was given intraperitoneally. After 4 days the animals were sacrificed and the Pu content in livers, kidneys, femurs and carcasses was determined by the liquid scintillation method. It was found that, as compared with the control, 3,4,3 LICAM(C) removed 83% of the Pu activity deposited in the liver, 71% of that in the femur and 79% of the Pu in the whole body. The Pu content in the kidneys exceeded the control value by about 50%. Na3CaDTPA removed 96, 86, 40 and 72% of plutonium from the liver, kidneys, femurs and carcasses respectively. Tetra-DHB-spermine caused the excretion of 50, 57 and 39% of Pu from liver, bone and whole body respectively. The retention of Pu in the kidneys was increased to 400% of the control value.

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Removal of239Pu from mice with 3,4,3 LICAM(C) or N, N?, N?, N?-tetra-(2,3-dihydroxybenzoyl)-spermine

Szot

Rochalska

Wojewódzka

et al. 1986

Radiat Environ Biophys

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5 The Present Status of Chelating Agents in Medicine

May¹,

Bulman²

1983

Progress in Medicinal Chemistry

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Removal of²³⁹Pu, Internally Deposited in Mice, by Means of Diethylenetriaminepentamethylenephosphonates

Cited by 2 publications

References 2 publications

Removal of239Pu from mice with 3,4,3 LICAM(C) or N, N?, N?, N?-tetra-(2,3-dihydroxybenzoyl)-spermine

Removal of239Pu from mice with 3,4,3 LICAM(C) or N, N?, N?, N?-tetra-(2,3-dihydroxybenzoyl)-spermine

5 The Present Status of Chelating Agents in Medicine

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Removal of239Pu, Internally Deposited in Mice, by Means of Diethylenetriaminepentamethylenephosphonates

Cited by 2 publications

References 2 publications

Removal of239Pu from mice with 3,4,3 LICAM(C) or N, N?, N?, N?-tetra-(2,3-dihydroxybenzoyl)-spermine

Removal of239Pu from mice with 3,4,3 LICAM(C) or N, N?, N?, N?-tetra-(2,3-dihydroxybenzoyl)-spermine

5 The Present Status of Chelating Agents in Medicine

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Removal of²³⁹Pu, Internally Deposited in Mice, by Means of Diethylenetriaminepentamethylenephosphonates