Uranium (U) concentration and the activities of 238 U, 234 U, and 230 Th were determined for groundwaters, spring waters, and lake water collected from the Shihongtan sandstone-hosted U ore district and in the surrounding area, NW China. The results show that the groundwaters from the oxidizing aquifer with high dissolved oxygen concentration (O 2 ) and oxidation-reduction potential (Eh) are enriched in U. The high U concentration of groundwaters may be due to the interaction between these oxidizing groundwaters and U ore bodies, which would result in U that is not in secular equilibrium. Uranium is re-precipitated as uraninite on weathered surfaces and organic material, forming localized ore bodies in the sandstone-hosted aquifer. The 234 U/ 238 U, 230 Th/ 234 U, and 230 Th/ 238 U activity ratios (ARs) for most water samples show obvious deviations from secular equilibrium (0.27-2.86), indicating the presence of water-rock/ore interactions during the last 1.7 Ma and probably longer. The 234 U/ 238 U AR generally increases with decreasing U concentrations in the groundwaters, suggesting that mixing of two water sources may occur in the aquifer. This is consistent with the fact that most of the U ore bodies in the deposit have a tabular shape originati from mixing between a relatively saline fluid and a more rapidly flowing U-bearing meteoric water.